Il21 interleukin 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il21provided by MGI
Official Full Name: interleukin 21provided by MGI
Primary source: MGI:MGI:1890474
See related: Ensembl:ENSMUSG00000027718 AllianceGenome:MGI:1890474
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IL-21
Summary: Enables cytokine receptor binding activity. Involved in cellular response to virus; lymphocyte activation involved in immune response; and positive regulation of immunoglobulin production. Acts upstream of or within positive regulation of cytokine production; positive regulation of natural killer cell differentiation; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in extracellular space. Is expressed in ductus deferens; epididymis; liver; and testis. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency 11; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 3 B; 3 18.36 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (37276908..37286785, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (37222759..37232636, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A pathologically expanded, clonal lineage of IL-21-producing CD4+ T cells drives inflammatory neuropathy.
Title: A pathologically expanded, clonal lineage of IL-21-producing CD4+ T cells drives inflammatory neuropathy.
CD4 T Cell-Derived IL-21 Is Critical for Sustaining Plasmodium Infection-Induced Germinal Center Responses and Promoting the Selection of Memory B Cells with Recall Potential.
Title: CD4 T Cell-Derived IL-21 Is Critical for Sustaining Plasmodium Infection-Induced Germinal Center Responses and Promoting the Selection of Memory B Cells with Recall Potential.
IL-21, not IL-17A, exacerbates murine primary biliary cholangitis.
Title: IL-21, not IL-17A, exacerbates murine primary biliary cholangitis.
IL-21 collaborates with anti-TIGIT to restore NK cell function in chronic HBV infection.
Title: IL-21 collaborates with anti-TIGIT to restore NK cell function in chronic HBV infection.
Interleukin-21 knockout reduces bone loss in ovariectomized mice by inhibiting osteoclastogenesis.
Title: Interleukin-21 knockout reduces bone loss in ovariectomized mice by inhibiting osteoclastogenesis.
T Follicular Helper Cells in Tertiary Lymphoid Structure Contribute to Renal Fibrosis by IL-21.
Title: T Follicular Helper Cells in Tertiary Lymphoid Structure Contribute to Renal Fibrosis by IL-21.
IL-21/IL-21R Promotes the Pro-Inflammatory Effects of Macrophages during C. muridarum Respiratory Infection.
Title: IL-21/IL-21R Promotes the Pro-Inflammatory Effects of Macrophages during C. muridarum Respiratory Infection.
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation.
Title: IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation.
Cutting Edge: IL-21 and Tissue-Specific Signals Instruct Tbet+CD11c+ B Cell Development following Viral Infection.
Title: Cutting Edge: IL-21 and Tissue-Specific Signals Instruct Tbet+CD11c+ B Cell Development following Viral Infection.
Targeting interleukin-21 inhibits stress overload-induced cardiac remodelling via the TIMP4/MMP9 signalling pathway.
Title: Targeting interleukin-21 inhibits stress overload-induced cardiac remodelling via the TIMP4/MMP9 signalling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (191)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (11) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-2 receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in T follicular helper cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell maturation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germinal center B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-10 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of natural killer cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of natural killer cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of natural killer cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of B cell differentiation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-10 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of natural killer cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of natural killer cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291041.1 → NP_001277970.1 interleukin-21 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL662823

Consensus CDS

CCDS71236.1

UniProtKB/TrEMBL

A5J0L5, E9PX58

Related

ENSMUSP00000124668.2, ENSMUST00000161015.2
NM_021782.3 → NP_068554.1 interleukin-21 isoform 2 precursor

See identical proteins and their annotated locations for NP_068554.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks a segment in the 3' coding region which results in a frameshift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AL662823

Consensus CDS

CCDS17317.1

UniProtKB/Swiss-Prot

Q9ES17

UniProtKB/TrEMBL

A5J0L5, Q5SUE2

Related

ENSMUSP00000029273.2, ENSMUST00000029273.8