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    CBL8 calcineurin B-like protein 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842756, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CBL8
    Official Full Name
    calcineurin B-like protein 8
    Primary source
    TAIR:AT1G64480
    Locus tag
    AT1G64480
    See related
    Araport:AT1G64480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    calcineurin B-like protein 8; F1N19.5; F1N19_5
    Summary
    calcineurin B-like protein 8, member of plant-specific family of calcium sensor proteins containing 3 EF-hand motifs
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    Genomic context

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    See CBL8 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (23947794..23950361, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Glycine-rich protein family Neighboring gene collagen triple helix protein Neighboring gene phosphatidylinositol 4-kinase gamma-like protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DEK, chromatin associated protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Calmodulins and calcineurin B-like proteins: calcium sensors for specific signal response coupling in plants. Luan S, et al. Plant Cell, 2002. PMID 12045290, Free PMC Article
    2. CBL-mediated targeting of CIPKs facilitates the decoding of calcium signals emanating from distinct cellular stores. Batistic O, et al. Plant J, 2010 Jan. PMID 19832944
    3. A protein kinase, calcineurin B-like protein-interacting protein Kinase9, interacts with calcium sensor calcineurin B-like Protein3 and regulates potassium homeostasis under low-potassium stress in Arabidopsis. Liu LL, et al. Plant Physiol, 2013 Jan. PMID 23109687, Free PMC Article
    4. Phosphorylation of calcineurin B-like (CBL) calcium sensor proteins by their CBL-interacting protein kinases (CIPKs) is required for full activity of CBL-CIPK complexes toward their target proteins. Hashimoto K, et al. J Biol Chem, 2012 Mar 9. PMID 22253446, Free PMC Article
    5. The NAF domain defines a novel protein-protein interaction module conserved in Ca2+-regulated kinases. Albrecht V, et al. EMBO J, 2001 Mar 1. PMID 11230129, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium-mediated signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    calcineurin B-like protein 8
    NP_001319319.1
    • calcineurin B-like protein 8 (CBL8); CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), Calcineurin B protein (InterPro:IPR015757), Recoverin (InterPro:IPR001125), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992), EF-hand (InterPro:IPR018248), EF-HAND 2 (InterPro:IPR018249); BEST Arabidopsis thaliana protein match is: Calcium-binding EF-hand family protein (TAIR:AT5G24270.2); Has 8036 Blast hits to 8016 proteins in 760 species: Archae - 0; Bacteria - 12; Metazoa - 3984; Fungi - 1032; Plants - 1911; Viruses - 0; Other Eukaryotes - 1097 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      23947794..23950361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001334162.1 → NP_001319319.1  calcineurin B-like protein 8 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FUQ7, Q9SGW7
      UniProtKB/TrEMBL
      A0A178W4X2, A0A384KGE1, Q0V872
      Conserved Domains (1) summary
      COG5126
      Location:29 → 187
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. NM_001334163.1 → NP_001322653.1  calcineurin B-like protein 8 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FUQ7, Q9SGW7
      UniProtKB/TrEMBL
      A0A178W4X2, A0A384KGE1, Q0V872
      Conserved Domains (1) summary
      COG5126
      Location:29 → 187
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    3. NM_105123.2 → NP_176629.1  calcineurin B-like protein 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176629.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FUQ7, Q9SGW7
      UniProtKB/TrEMBL
      A0A178W4X2, A0A384KGE1, Q0V872
      Conserved Domains (1) summary
      COG5126
      Location:29 → 187
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    4. NM_001334164.1 → NP_001322654.1  calcineurin B-like protein 8 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W6J9, A0A1P8AUP2, A0A384KNV3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FUQ7.1

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