Dcxr dicarbonyl L-xylulose reductase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcxrprovided by MGI
Official Full Name: dicarbonyl L-xylulose reductaseprovided by MGI
Primary source: MGI:MGI:1915130
See related: Ensembl:ENSMUSG00000039450 AllianceGenome:MGI:1915130
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: XR; 0610038K04Rik; 1810027P18Rik
Summary: Enables L-xylulose reductase (NADPH) activity. Involved in D-glucuronate catabolic process to D-xylulose 5-phosphate and glucose metabolic process. Acts upstream of or within NADP metabolic process and xylulose metabolic process. Located in brush border and microvillus. Is active in cytosol. Is expressed in adrenal gland; alimentary system; genitourinary system; respiratory system; and thymus. Human ortholog(s) of this gene implicated in pentosuria. Orthologous to human DCXR (dicarbonyl and L-xylulose reductase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in kidney adult (RPKM 258.2), liver adult (RPKM 151.9) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 84.47 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120615372..120618110, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120724546..120727284, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DCXR might function in the metabolism of glucose or carbonyl compounds, and play a protective role in a kidney which is under hyperglycemic pressure.
Title: Transgenic mice over-expressing dicarbonyl/L-xylulose reductase gene crossed with KK-Ay diabetic model mice: an animal model for the metabolism of renal carbonyl compounds.
highly expressed in kidney and liver
Title: Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-xylulose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-xylulose reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables L-xylulose reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info	PubMed
enables carbonyl reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on CH-OH group of donors	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate	IDA Inferred from Direct Assay more info	PubMed
involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate	ISO Inferred from Sequence Orthology more info	PubMed
involved_in D-xylose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within NADP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xylulose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within xylulose metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xylulose metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: L-xylulose reductase

Names: diacetyl/L-xylulose reductase

NP_001334537.1

EC 1.1.1.10

NP_080704.2

EC 1.1.1.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.