lect-2 Leukocyte cell-derived chemotaxin-2 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lect-2
Official Full Name: Leukocyte cell-derived chemotaxin-2 homolog
Primary source: WormBase:WBGene00019407
Locus tag: CELE_K05F1.5
See related: AllianceGenome:WB:WBGene00019407
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable metal ion binding activity. Involved in innervation; regulation of dendrite extension; and regulation of dendrite morphogenesis. Located in several cellular components, including cell surface; perikaryon; and sensory dendrite. Is expressed in body wall musculature; coelomocyte; head neurons; and ventral cord neurons. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung adenocarcinoma. Orthologous to human LECT2 (leukocyte cell derived chemotaxin 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lect-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (5790723..5794402)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LECT-2/Chondromodulin II acts as a muscle-derived, diffusible cofactor together with a skin-derived cell adhesion complex to orchestrate the molecular interactions of three tissues during patterning of somatosensory dendrites.
Title: Muscle- and Skin-Derived Cues Jointly Orchestrate Patterning of Somatosensory Dendrites.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K05F1.5 (e-PCR)
- UniSTS:319489

K05F1.4 (e-PCR)
- UniSTS:314615

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in innervation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendrite extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in sensory dendrite	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Leukocyte cell-derived chemotaxin-2 homolog

NP_495141.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5790723..5794402

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062740.8 → NP_495141.2 Leukocyte cell-derived chemotaxin-2 homolog [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1B1LVF5, Q21241

Conserved Domains (1) summary

pfam01551
Location:60 → 166

Peptidase_M23; Peptidase family M23