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    AIL6 AINTEGUMENTA-like 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830915, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AIL6
    Official Full Name
    AINTEGUMENTA-like 6
    Primary source
    TAIR:AT5G10510
    Locus tag
    AT5G10510
    See related
    Araport:AT5G10510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AINTEGUMENTA-like 6; F12B17.140; F12B17_140; PLETHORA 3; PLT3
    Summary
    Encodes an AP2-domain transcription factor involved in root stem cell identity and root development. It is also required to maintain high levels of PIN1 expression at the periphery of the meristem and modulate local auxin production in the central region of the SAM which underlies phyllotactic transitions.
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    Genomic context

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    See AIL6 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (3315401..3320323)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Kinase interacting (KIP1-like) family protein Neighboring gene ncRNA Neighboring gene ROP binding protein kinases 1 Neighboring gene tRNA-Arg Neighboring gene Zincin-like metalloproteases family protein Neighboring gene Concanavalin A-like lectin protein kinase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AINTEGUMENTA-LIKE6 regulates cellular differentiation in flowers. Krizek BA, et al. Plant Mol Biol, 2012 Feb. PMID 22076630
    2. Intronic sequences are required for AINTEGUMENTA-LIKE6 expression in Arabidopsis flowers. Krizek BA. BMC Res Notes, 2015 Oct 12. PMID 26459062, Free PMC Article
    3. AINTEGUMENTA and redundant AINTEGUMENTA-LIKE6 are required for bract outgrowth in Arabidopsis. Manuela D, et al. J Exp Bot, 2024 Jul 10. PMID 38547364
    4. AINTEGUMENTA and AINTEGUMENTA-LIKE6 directly regulate floral homeotic, growth, and vascular development genes in young Arabidopsis flowers. Krizek BA, et al. J Exp Bot, 2021 Jul 28. PMID 34013313, Free PMC Article
    5. AINTEGUMENTA and AINTEGUMENTA-LIKE6 act redundantly to regulate Arabidopsis floral growth and patterning. Krizek B. Plant Physiol, 2009 Aug. PMID 19542297, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AINTEGUMENTA and redundant AINTEGUMENTA-LIKE6 are required for bract outgrowth in Arabidopsis.
      Title: AINTEGUMENTA and redundant AINTEGUMENTA-LIKE6 are required for bract outgrowth in Arabidopsis.
    2. AINTEGUMENTA and AINTEGUMENTA-LIKE6 directly regulate floral homeotic, growth, and vascular development genes in young Arabidopsis flowers.
      Title: AINTEGUMENTA and AINTEGUMENTA-LIKE6 directly regulate floral homeotic, growth, and vascular development genes in young Arabidopsis flowers.
    3. This study characterized the effects of three PLETHORA (PLT) transcription factors, PLT3, PLT5, and PLT7, during lateral root outgrowth.
      Title: PLETHORA transcription factors orchestrate de novo organ patterning during Arabidopsis lateral root outgrowth.
    4. AIL6 regulates biological pathways that are critical for cell wall remodeling and defense.
      Title: RNA-Seq Links the Transcription Factors AINTEGUMENTA and AINTEGUMENTA-LIKE6 to Cell Wall Remodeling and Plant Defense Pathways.
    5. ANT and AIL6 directly induce LFY expression in response to auxin to promote the onset of flower formation.
      Title: AINTEGUMENTA and AINTEGUMENTA-LIKE6/PLETHORA3 Induce LEAFY Expression in Response to Auxin to Promote the Onset of Flower Formation in Arabidopsis.
    6. The results presented here indicate that AIL6 intronic sequences serve as transcriptional enhancer elements.
      Title: Intronic sequences are required for AINTEGUMENTA-LIKE6 expression in Arabidopsis flowers.
    7. AIL genes exhibit unequal genetic redundancy with roles for AIL5, AIL6, and AIL7 only revealed in the absence of ANT function. AIL5, AIL6, and AIL7 act in a dose dependent manners in ant and other mutant backgrounds.
      Title: AINTEGUMENTA-LIKE genes have partly overlapping functions with AINTEGUMENTA but make distinct contributions to Arabidopsis thaliana flower development.
    8. PLT3, PLT5, and PLT7 additionally regulate and require the shoot-promoting factor CUP-SHAPED COTYLEDON2 (CUC2) to complete the shoot-formation program.
      Title: PLETHORA Genes Control Regeneration by a Two-Step Mechanism.
    9. PLT proteins are key regulators of PIN1 activity in control of phyllotaxis. PLT3, PLT5, and PLT7 are essential for normal phyllotaxis. [PLT3]
      Title: Arabidopsis PLETHORA transcription factors control phyllotaxis.
    10. In A. thaliana, three transcriptional regulators implicated in phyllotaxis, PLETHORA3 (PLT3), PLT5, and PLT7, are expressed in incipient lateral root primordia where they are required for primordium development and lateral root emergence.
      Title: Phyllotaxis and rhizotaxis in Arabidopsis are modified by three PLETHORA transcription factors.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001343115.1
    NM_001343118.1
    NM_001343119.1
    NM_121089.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within callus formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lateral root formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf phyllotactic patterning IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of shoot apical meristem identity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phyllotactic patterning IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within plant organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of floral meristem growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    AINTEGUMENTA-like 6
    NP_001190279.1
    • AINTEGUMENTA-like 6 (AIL6); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: AINTEGUMENTA-like 7 (TAIR:AT5G65510.1).
    NP_001318528.1
    • AINTEGUMENTA-like 6 (AIL6); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: AINTEGUMENTA-like 7 (TAIR:AT5G65510.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_196613.2
    • AINTEGUMENTA-like 6 (AIL6); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: AINTEGUMENTA-like 7 (TAIR:AT5G65510.1); Has 34181 Blast hits to 11297 proteins in 411 species: Archae - 14; Bacteria - 43; Metazoa - 1028; Fungi - 1178; Plants - 6969; Viruses - 2; Other Eukaryotes - 24947 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      3315401..3320323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343116.1 → NP_001331270.1  AINTEGUMENTA-like 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y3P3

    2. NM_001343117.1 → NP_001331269.1  AINTEGUMENTA-like 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BDC1, A0A5S9Y3P3

    3. NM_001203350.1 → NP_001190279.1  AINTEGUMENTA-like 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190279.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y3P3, F4KGW7
      Conserved Domains (2) summary
      smart00380
      Location:268 → 360
      AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs
      cl00033
      Location:390 → 454
      AP2; DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor ...

    4. NM_001343115.1 → NP_001318528.1  AINTEGUMENTA-like 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q52QU2, Q6PQQ5, Q9LXA3
      UniProtKB/TrEMBL
      A0A2H1ZE66, A0A654G0C4

    5. NM_001343118.1 → NP_001331268.1  AINTEGUMENTA-like 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y3P3

    6. NM_121089.3 → NP_196613.2  AINTEGUMENTA-like 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196613.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y3P3, F4KGW9
      Conserved Domains (2) summary
      smart00380
      Location:253 → 325
      AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs
      cl00033
      Location:355 → 419
      AP2; DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor ...

    7. NM_001343119.1 → NP_001331267.1  AINTEGUMENTA-like 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BDC1, A0A5S9Y3P3
    Nucleotide Protein
    Heading Accession and Version

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