ERL2 ERECTA-like 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ERL2
Official Full Name: ERECTA-like 2
Primary source: TAIR:AT5G07180
Locus tag: AT5G07180
See related: Araport:AT5G07180
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ERECTA-like 2; T28J14.120; T28J14_120
Summary: Encodes a receptor-like kinase that, together with ER and ERL1 governs the initial decision of protodermal cells to either divide proliferatively to produce pavement cells or divide asymmetrically to generate stomatal complexes. It is also important for maintaining stomatal stem cell activity and preventing terminal differentiation of the meristemoid into the guard mother cell. When heterozygous in an er/erl1 null background, plants are female sterile due to cell division defect in the integuments.
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Genomic context

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See ERL2 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 27

Sequence:: Chromosome: 5; NC_003076.8 (2227439..2233587, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ERECTA receptor-kinases play a key role in the appropriate timing of seed germination under changing salinity.
Title: ERECTA receptor-kinases play a key role in the appropriate timing of seed germination under changing salinity.
ER-family signalling is crucial for ensuring proper expression domains of floral meristem and floral organ identity determinants, and further implies the existence of a non-canonical downstream pathway.
Title: Regulation of floral patterning and organ identity by Arabidopsis ERECTA-family receptor kinase genes.
ER, ERL1 and ERL2 proteins are essential for PIN1 expression in the forming midvein of future leaf primordia and in the vasculature of emerging leaves.
Title: ERECTA family genes regulate auxin transport in the shoot apical meristem and forming leaf primordia.
The ER family regulates stem cell homeostasis via buffering its cytokinin responsiveness in the Shoot apical meristem (SAM).
Title: ERECTA-family receptor kinases regulate stem cell homeostasis via buffering its cytokinin responsiveness in the shoot apical meristem.
Both ER/ERL1/ERL2 and MPK3/MPK6 play important roles in normal anther lobe formation and anther cell differentiation.
Title: Regulation of Arabidopsis early anther development by the mitogen-activated protein kinases, MPK3 and MPK6, and the ERECTA and related receptor-like kinases.
ERL2 is haploinsufficient for maintaining female fertility in the absence of ER and ERL1.
Title: Haploinsufficiency after successive loss of signaling reveals a role for ERECTA-family genes in Arabidopsis ovule development.
Three ERECTA-family leucine-rich repeat-receptor-like kinases (ER, ERL1,ERL2) together control stomatal patterning, with specific family members regulating specification of stomatal stem cell fate & differentiation of guard cells [ERL2]
Title: Stomatal patterning and differentiation by synergistic interactions of receptor kinases.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001342930.1

Supported by ESTs:

NM_120800.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo sac development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within plant ovule development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within stomatal complex morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: ERECTA-like 2

NP_196335.2

ERECTA-like 2 (ERL2); FUNCTIONS IN: kinase activity; INVOLVED IN: stomatal complex morphogenesis, embryo sac development, ovule development; LOCATED IN: endomembrane system; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: ERECTA-like 1 (TAIR:AT5G62230.1); Has 220369 Blast hits to 138160 proteins in 3652 species: Archae - 160; Bacteria - 22012; Metazoa - 72756; Fungi - 10822; Plants - 87289; Viruses - 476; Other Eukaryotes - 26854 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

2227439..2233587 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_120800.4 → NP_196335.2 ERECTA-like 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_196335.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6XAT2, Q9LYP7

UniProtKB/TrEMBL

A0A178UL85, A0A5S9Y2Y9, A0A654FZK6

Conserved Domains (2) summary

PLN00113
Location:14 → 919

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:268 → 289

LRR_RI; leucine-rich repeat [structural motif]
NM_001342930.1 → NP_001331523.1 ERECTA-like 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BE60