U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    BLH2 BEL1-like homeodomain 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829840, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    BLH2
    Official Full Name
    BEL1-like homeodomain 2
    Primary source
    TAIR:AT4G36870
    Locus tag
    AT4G36870
    See related
    Araport:AT4G36870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AP22.90; AP22_90; BEL1-like homeodomain 2; SAW1; SAWTOOTH 1
    Summary
    Encodes a member of the BEL family of homeodomain proteins. Plants doubly mutant for saw1/saw2 (blh2/blh4) have serrated leaves. BP is expressed in the serrated leaves, therefore saw1/saw2 may act redundantly to repress BP in leaves.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See BLH2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (17368915..17374011)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene PQ-loop repeat family protein / transmembrane family protein Neighboring gene LIM domain-containing protein Neighboring gene cysteine proteinase1 Neighboring gene Nucleotide-diphospho-sugar transferases superfamily protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. SAW homeodomain transcription factors regulate initiation of leaf margin serrations. Jeon HW, et al. J Exp Bot, 2021 Feb 27. PMID 33247922
    2. Transcription Factors BLH2 and BLH4 Regulate Demethylesterification of Homogalacturonan in Seed Mucilage. Xu Y, et al. Plant Physiol, 2020 May. PMID 32111623, Free PMC Article
    3. The Arabidopsis BEL1-LIKE HOMEODOMAIN proteins SAW1 and SAW2 act redundantly to regulate KNOX expression spatially in leaf margins. Kumar R, et al. Plant Cell, 2007 Sep. PMID 17873098, Free PMC Article
    4. A central role of Arabidopsis thaliana ovate family proteins in networking and subcellular localization of 3-aa loop extension homeodomain proteins. Hackbusch J, et al. Proc Natl Acad Sci U S A, 2005 Mar 29. PMID 15781858, Free PMC Article
    5. Transcriptional Regulation of Arabidopsis Polycomb Repressive Complex 2 Coordinates Cell-Type Proliferation and Differentiation. de Lucas M, et al. Plant Cell, 2016 Oct. PMID 27650334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SAW homeodomain transcription factors regulate initiation of leaf margin serrations.
      Title: SAW homeodomain transcription factors regulate initiation of leaf margin serrations.
    2. These data suggest that BLH2/SAW1 and BLH4/SAW2 establish leaf shape by repressing growth in specific subdomains of the leaf at least in part by repressing expression of one or more of the KNOX genes. [SAW1]
      Title: The Arabidopsis BEL1-LIKE HOMEODOMAIN proteins SAW1 and SAW2 act redundantly to regulate KNOX expression spatially in leaf margins.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001036720.5
    NM_001342426.1
    NM_001342427.1
    NM_119851.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within leaf morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within mucilage pectin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    BEL1-like homeodomain 2
    NP_001031797.4
    • BEL1-like homeodomain 2 (BLH2); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), POX (InterPro:IPR006563), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: BEL1-like homeodomain 4 (TAIR:AT2G23760.3); Has 5744 Blast hits to 5713 proteins in 356 species: Archae - 0; Bacteria - 3; Metazoa - 2532; Fungi - 390; Plants - 2517; Viruses - 0; Other Eukaryotes - 302 (source: NCBI BLink).
    NP_195405.4
    • BEL1-like homeodomain 2 (BLH2); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), POX (InterPro:IPR006563), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: BEL1-like homeodomain 4 (TAIR:AT2G23760.3); Has 5744 Blast hits to 5713 proteins in 356 species: Archae - 0; Bacteria - 3; Metazoa - 2532; Fungi - 390; Plants - 2517; Viruses - 0; Other Eukaryotes - 302 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17368915..17374011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001036720.5 → NP_001031797.4  BEL1-like homeodomain 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031797.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JQI6, O23196, Q9SW80
      UniProtKB/TrEMBL
      A0A5S9XZN0
      Conserved Domains (2) summary
      smart00574
      Location:310 → 445
      POX; domain associated with HOX domains
      pfam05920
      Location:516 → 555
      Homeobox_KN; Homeobox KN domain

    2. NM_001342426.1 → NP_001329338.1  BEL1-like homeodomain 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UTW0, A0A1P8B7E4

    3. NM_119851.6 → NP_195405.4  BEL1-like homeodomain 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195405.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JQI6, O23196, Q9SW80
      UniProtKB/TrEMBL
      A0A5S9XZN0
      Conserved Domains (2) summary
      smart00574
      Location:310 → 445
      POX; domain associated with HOX domains
      pfam05920
      Location:516 → 555
      Homeobox_KN; Homeobox KN domain

    4. NM_001342427.1 → NP_001329337.1  BEL1-like homeodomain 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UVR5, A0A1P8B7F4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SW80.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.