GTG2 GPCR-type G protein 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GTG2
Official Full Name: GPCR-type G protein 2
Primary source: TAIR:AT4G27630
Locus tag: AT4G27630
See related: Araport:AT4G27630
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: GPCR-type G protein 2; T29A15.120; T29A15_120
Summary: Encodes a GPCR-type G protein receptor with nine predicted transmembrane domains. The protein binds abscisic acid (ABA) and is predicted to function as an ABA receptor. It has GTP-binding and GTPase activity and binds to ABA more effectively in the presence of GDP. GTG2 binds to GPA1, the alpha subunit of the heterotrimeric G protein. GPA1 (in its GTP-bound state) affects the GTP binding and GTPase activity of GTG2 and may act to down-regulate GTG2 binding to ABA. GTG2 is widely expressed throughout the plant and appears to be involved in the regulation of several ABA-dependent responses including seed germination, plant development, and promotion of stomatal closure. GTG2 transcript levels do not appear to change in response to ABA or abiotic stresses.
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Genomic context

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See GTG2 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 14

Sequence:: Chromosome: 4; NC_003075.7 (13791642..13797305, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GTGs contribute to fertility, plant growth, and responses to light and sugars, but our molecular and genetic data using these mutants indicate that they respond normally in classic ABA responses.
Title: G protein-coupled receptor-type G proteins are required for light-dependent seedling growth and fertility in Arabidopsis.
Study identifies 2 proteins homologous to orphan vertebrate GPCR (GPR89) and interact with the Arabidopsis G protein alpha subunit, GPA1, have intrinsic GTP-binding and GTPase activity; these proteins are named GTG1 and GTG2 (At4g27630).
Title: Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001203925.2

Supported by ESTs:

NM_001341872.1

Supported by ESTs:

NM_001341873.1

Supported by ESTs:

NM_001341874.1

Supported by ESTs:

NM_001341875.1

Supported by ESTs:

NM_118899.4

Supported by ESTs:

NM_179224.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables abscisic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within post-embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vegetative to reproductive phase transition of meristem	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: GPCR-type G protein 2

NP_001190854.1

GPCR-type G protein 2 (GTG2); CONTAINS InterPro DOMAIN/s: GPCR 89-related (InterPro:IPR015672), Protein of unknown function DUF3735 (InterPro:IPR022535); BEST Arabidopsis thaliana protein match is: GPCR-type G protein 1 (TAIR:AT1G64990.2).

NP_001320077.1

GPCR-type G protein 2 (GTG2); CONTAINS InterPro DOMAIN/s: GPCR 89-related (InterPro:IPR015672), Protein of unknown function DUF3735 (InterPro:IPR022535); BEST Arabidopsis thaliana protein match is: GPCR-type G protein 1 (TAIR:AT1G64990.2); Has 349 Blast hits to 345 proteins in 148 species: Archae - 2; Bacteria - 0; Metazoa - 168; Fungi - 65; Plants - 51; Viruses - 0; Other Eukaryotes - 63 (source: NCBI BLink).

NP_194493.2

GPCR-type G protein 2 (GTG2); CONTAINS InterPro DOMAIN/s: GPCR 89-related (InterPro:IPR015672), Protein of unknown function DUF3735 (InterPro:IPR022535); BEST Arabidopsis thaliana protein match is: GPCR-type G protein 1 (TAIR:AT1G64990.2); Has 371 Blast hits to 361 proteins in 150 species: Archae - 2; Bacteria - 0; Metazoa - 174; Fungi - 67; Plants - 53; Viruses - 0; Other Eukaryotes - 75 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

13791642..13797305 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001203925.2 → NP_001190854.1 GPCR-type G protein 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190854.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9XWU3, F4JJP9

Conserved Domains (2) summary

pfam12430
Location:308 → 466

ABA_GPCR; Abscisic acid G-protein coupled receptor

pfam12537
Location:142 → 209

GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
NM_001341873.1 → NP_001329564.1 GPCR-type G protein 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B832
NM_118899.4 → NP_194493.2 GPCR-type G protein 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194493.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G0WVT7, Q0WQG8, Q304A2, Q3E9V6, Q9T087

UniProtKB/TrEMBL

A0A5S9XWU3, A0A654FTK6

Conserved Domains (2) summary

pfam12430
Location:284 → 442

ABA_GPCR; Abscisic acid G-protein coupled receptor

pfam12537
Location:142 → 209

GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
NM_001341874.1 → NP_001329563.1 GPCR-type G protein 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B833
NM_001341872.1 → NP_001320077.1 GPCR-type G protein 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UYI5
NM_179224.2 → NP_849555.1 GPCR-type G protein 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849555.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UYI5

Conserved Domains (2) summary

pfam12430
Location:165 → 323

ABA_GPCR; Abscisic acid G-protein coupled receptor

pfam12537
Location:23 → 90

GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
NM_001341875.1 → NP_001329565.1 GPCR-type G protein 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UWB2, A0A1P8B836