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    SIC hydroxyproline-rich glycoprotein family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828552, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SIC
    Official Full Name
    hydroxyproline-rich glycoprotein family protein
    Primary source
    TAIR:AT4G24500
    Locus tag
    AT4G24500
    See related
    Araport:AT4G24500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F22K18.300; F22K18_300; SICKLE
    Summary
    Encodes a proline-rich protein SICKLE (SIC). Required for development and abiotic stress tolerance. Involved in microRNA biogenesis.
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    Genomic context

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    See SIC in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (12658433..12660667)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene GATA-type zinc finger protein with TIFY domain-containing protein Neighboring gene Protein kinase superfamily protein Neighboring gene RAB geranylgeranyl transferase alpha subunit 1 Neighboring gene ncRNA Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene P450 reductase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Absence of SICKLE triggers programed cell death by disturbing alternative splicing and decay of mRNAs. Wu C, et al. Plant Physiol, 2023 Jul 3. PMID 36974901, Free PMC Article
    2. The Arabidopsis sickle Mutant Exhibits Altered Circadian Clock Responses to Cool Temperatures and Temperature-Dependent Alternative Splicing. Marshall CM, et al. Plant Cell, 2016 Oct. PMID 27624757, Free PMC Article
    3. Arabidopsis proline-rich protein important for development and abiotic stress tolerance is involved in microRNA biogenesis. Zhan X, et al. Proc Natl Acad Sci U S A, 2012 Oct 30. PMID 23071326, Free PMC Article
    4. ROTUNDA3 function in plant development by phosphatase 2A-mediated regulation of auxin transporter recycling. Karampelias M, et al. Proc Natl Acad Sci U S A, 2016 Mar 8. PMID 26888284, Free PMC Article
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Absence of SICKLE triggers programed cell death by disturbing alternative splicing and decay of mRNAs.
      Title: Absence of SICKLE triggers programed cell death by disturbing alternative splicing and decay of mRNAs.
    2. Data show that ROTUNDA3 (RON3; At4g24500) protein as a regulator of the protein phosphatase 2A-driven PIN-FORMED (PIN) auxin transport recycling and its importance in auxin transport-related plant developmental programs.
      Title: ROTUNDA3 function in plant development by phosphatase 2A-mediated regulation of auxin transporter recycling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203893.1
    NM_001341679.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within entrainment of circadian clock IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within entrainment of circadian clock IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization involved in auxin polar transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of auxin polar transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hydroxyproline-rich glycoprotein family protein
    NP_001190822.1
    • hydroxyproline-rich glycoprotein family protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 10 growth stages.
    NP_001320056.1
    • hydroxyproline-rich glycoprotein family protein; Has 273 Blast hits to 270 proteins in 79 species: Archae - 0; Bacteria - 25; Metazoa - 136; Fungi - 37; Plants - 63; Viruses - 0; Other Eukaryotes - 12 (source: NCBI BLink).
    NP_567704.1
    • hydroxyproline-rich glycoprotein family protein; Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12658433..12660667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118583.4 → NP_567704.1  hydroxyproline-rich glycoprotein family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567704.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8H0Z3, Q94AJ0, Q9SB47
      UniProtKB/TrEMBL
      A0A178V4U1, A0A5S9XVW1
      Conserved Domains (1) summary
      pfam15502
      Location:127 → 273
      MPLKIP; M-phase-specific PLK1-interacting protein

    2. NM_001203893.1 → NP_001190822.1  hydroxyproline-rich glycoprotein family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190822.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8H0Z3, Q94AJ0, Q9SB47
      UniProtKB/TrEMBL
      A0A178V4U1, A0A5S9XVW1
      Conserved Domains (1) summary
      pfam15502
      Location:127 → 273
      MPLKIP; M-phase-specific PLK1-interacting protein

    3. NM_001341679.1 → NP_001320056.1  hydroxyproline-rich glycoprotein family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V4U1, A0A5S9XVW1, A0A7G2F3E8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SB47.1

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