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    REN1 Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828560, updated on 18-Sep-2024

    Summary

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    Official Symbol
    REN1
    Official Full Name
    Rho GTPase activation protein (RhoGAP) with PH domain-containing protein
    Primary source
    TAIR:AT4G24580
    Locus tag
    AT4G24580
    See related
    Araport:AT4G24580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F22K18.220; F22K18_220; ROP1 ENHANCER 1
    Summary
    Encodes a Rho GTPase-activating protein that interacts with ROP1 (a Rho GTPase) and regulates pollen tube development. This protein can be observed at the apical tip of growing pollen tubes and on endocytic vesicles traveling to this region of the pollen tube.
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    Genomic context

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    See REN1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    24
    Sequence:
    Chromosome: 4; NC_003075.7 (12687879..12694656, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene dicarboxylate carrier 2 Neighboring gene RING finger protein Neighboring gene uncharacterized protein Neighboring gene pesticidal crystal cry8Ba protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new link between stress response and nucleolar function during pollen development in Arabidopsis mediated by AtREN1 protein. Reňák D, et al. Plant Cell Environ, 2014 Mar. PMID 23961845
    2. A tip-localized RhoGAP controls cell polarity by globally inhibiting Rho GTPase at the cell apex. Hwang JU, et al. Curr Biol, 2008 Dec 23. PMID 19108776, Free PMC Article
    3. Learning the lipid language of plant signalling. van Leeuwen W, et al. Trends Plant Sci, 2004 Aug. PMID 15358268
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in exocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in pollen tube IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rho GTPase activation protein (RhoGAP) with PH domain-containing protein
    NP_001320057.1
    • ROP1 ENHANCER 1 (REN1); CONTAINS InterPro DOMAIN/s: Pleckstrin homology-type (InterPro:IPR011993), Rho GTPase activation protein (InterPro:IPR008936), RhoGAP (InterPro:IPR000198), Pleckstrin homology (InterPro:IPR001849); BEST Arabidopsis thaliana protein match is: Rho GTPase activation protein (RhoGAP) with PH domain (TAIR:AT5G12150.1); Has 23967 Blast hits to 18190 proteins in 1193 species: Archae - 153; Bacteria - 3871; Metazoa - 11779; Fungi - 2242; Plants - 901; Viruses - 71; Other Eukaryotes - 4950 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12687879..12694656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341681.1 → NP_001329908.1  Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JQZ3, Q9SB53
      UniProtKB/TrEMBL
      A0A5S9XVW8, A0A654FSJ2
      Conserved Domains (4) summary
      TIGR02168
      Location:600 → 845
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00169
      Location:61 → 166
      PH; PH domain
      pfam00620
      Location:222 → 360
      RhoGAP; RhoGAP domain
      pfam14389
      Location:642 → 720
      Lzipper-MIP1; Leucine-zipper of ternary complex factor MIP1

    2. NM_001341680.1 → NP_001320057.1  Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JQZ3, Q9SB53
      UniProtKB/TrEMBL
      A0A5S9XVW8, A0A654FSJ2
      Conserved Domains (4) summary
      TIGR02168
      Location:600 → 845
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00169
      Location:61 → 166
      PH; PH domain
      pfam00620
      Location:222 → 360
      RhoGAP; RhoGAP domain
      pfam14389
      Location:642 → 720
      Lzipper-MIP1; Leucine-zipper of ternary complex factor MIP1

    3. NM_001341682.1 → NP_001329909.1  Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B965
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JQZ3.2

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