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    DUT1 DUTP-PYROPHOSPHATASE-LIKE 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823847, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DUT1
    Official Full Name
    DUTP-PYROPHOSPHATASE-LIKE 1
    Primary source
    TAIR:AT3G46940
    Locus tag
    AT3G46940
    See related
    Araport:AT3G46940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DUTP-PYROPHOSPHATASE-LIKE 1; F13I12.6
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    Genomic context

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    See DUT1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (17288134..17289006, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene kinase superfamily with octicosapeptide/Phox/Bem1p domain-containing protein Neighboring gene Protein kinase superfamily protein Neighboring gene Mitochondrial transcription termination factor family protein Neighboring gene ncRNA Neighboring gene RNA helicase, ATP-dependent, SK12/DOB1 protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation. Inoguchi N, et al. BMC Res Notes, 2015 Dec 15. PMID 26666293, Free PMC Article
    2. Purification, crystallization and preliminary crystallographic analysis of deoxyuridine triphosphate nucleotidohydrolase from Arabidopsis thaliana. Bajaj M, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2007 May 1. PMID 17565183, Free PMC Article
    3. The nucleotide metabolome of germinating Arabidopsis thaliana seeds reveals a central role for thymidine phosphorylation in chloroplast development. Niehaus M, et al. Plant Cell, 2022 Sep 27. PMID 35861422, Free PMC Article
    4. Homologous recombination is stimulated by a decrease in dUTPase in Arabidopsis. Dubois E, et al. PLoS One, 2011 Apr 26. PMID 21541310, Free PMC Article
    5. The SOS screen in Arabidopsis: a search for functions involved in DNA metabolism. Siaud N, et al. DNA Repair (Amst), 2010 May 4. PMID 20227352

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_114561.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dUTP diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dUMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dUTP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thymidine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DUTP-PYROPHOSPHATASE-LIKE 1
    NP_190278.1
    • DUTP-PYROPHOSPHATASE-LIKE 1 (DUT1); FUNCTIONS IN: hydrolase activity, dUTP diphosphatase activity; INVOLVED IN: DNA repair, 2'-deoxyribonucleotide metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DeoxyUTP pyrophosphatase domain, subfamily 1, (InterPro:IPR008181), DeoxyUTP pyrophosphatase domain (InterPro:IPR008180); Has 7764 Blast hits to 7750 proteins in 2463 species: Archae - 14; Bacteria - 4311; Metazoa - 248; Fungi - 161; Plants - 56; Viruses - 831; Other Eukaryotes - 2143 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      17288134..17289006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339288.1 → NP_001325766.1  DUTP-PYROPHOSPHATASE-LIKE 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LM85, A0A654FDH8

    2. NM_114561.4 → NP_190278.1  DUTP-PYROPHOSPHATASE-LIKE 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190278.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9STG6
      UniProtKB/TrEMBL
      A0A178VJ09
      Conserved Domains (1) summary
      PLN02547
      Location:2 → 166
      PLN02547; dUTP pyrophosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9STG6.1

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