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    Fes1A Fes1A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820091, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Fes1A
    Official Full Name
    Fes1A
    Primary source
    TAIR:AT3G09350
    Locus tag
    AT3G09350
    See related
    Araport:AT3G09350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Summary
    Encodes one of the Arabidopsis orthologs of the human Hsp70-binding protein 1 (HspBP-1) and yeast Fes1p: Fes1A (AT3G09350), Fes1B (AT3G53800), Fes1C (AT5G02150). Fes1A is cytosolic and associates with cytosolic Hsp70. Mutants showed increased heat-sensitive phenotype suggestion the involvement of Fes1A in acquired thermotolerance. Does not have nucleotide exchange factor activity in vitro.
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    Genomic context

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    See Fes1A in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (2870970..2873332)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Transmembrane amino acid transporter family protein Neighboring gene Transmembrane amino acid transporter family protein Neighboring gene ncRNA Neighboring gene Cyclin/Brf1-like TBP-binding protein Neighboring gene myb domain protein 3r-3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of Arabidopsis AtFes1A in cytosolic Hsp70 stability and abiotic stress tolerance. Zhang JX, et al. Plant J, 2010 May 1. PMID 20536787
    2. Increased fes1a thermotolerance is induced by BAG6 knockout. Fu C, et al. Plant Mol Biol, 2019 May. PMID 30796711
    3. A subcellular localization compendium of hydrogen peroxide-induced proteins. Inzé A, et al. Plant Cell Environ, 2012 Feb. PMID 21443605
    4. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The fes1a bag6 double mutant shows an increased short-term thermotolerance compared to fes1a.
      Title: Increased fes1a thermotolerance is induced by BAG6 knockout.
    2. AtFes1A appears to prevent cytosolic Hsp70 degradation, and acts as a negative regulator of heat-shock transcription.
      Title: The role of Arabidopsis AtFes1A in cytosolic Hsp70 stability and abiotic stress tolerance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084657.1
    NM_001161128.1
    NM_001337811.1
    NM_111769.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables Hsp70 protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fes1A
    NP_001078126.1
    • Fes1A (Fes1A); CONTAINS InterPro DOMAIN/s: Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: Fes1B (TAIR:AT3G53800.1); Has 594 Blast hits to 590 proteins in 194 species: Archae - 0; Bacteria - 0; Metazoa - 194; Fungi - 149; Plants - 182; Viruses - 0; Other Eukaryotes - 69 (source: NCBI BLink).
    NP_001154600.1
    • Fes1A (Fes1A); CONTAINS InterPro DOMAIN/s: Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: Fes1B (TAIR:AT3G53800.1); Has 594 Blast hits to 590 proteins in 194 species: Archae - 0; Bacteria - 0; Metazoa - 194; Fungi - 149; Plants - 182; Viruses - 0; Other Eukaryotes - 69 (source: NCBI BLink).
    NP_566349.1
    • Fes1A (Fes1A); CONTAINS InterPro DOMAIN/s: Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: Fes1C (TAIR:AT5G02150.1); Has 622 Blast hits to 617 proteins in 204 species: Archae - 0; Bacteria - 0; Metazoa - 202; Fungi - 158; Plants - 182; Viruses - 0; Other Eukaryotes - 80 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2870970..2873332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111769.2 → NP_566349.1  Fes1A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566349.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FAQ8, Q84J81, Q8LDQ1
      Conserved Domains (3) summary
      COG5064
      Location:36 → 248
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:102 → 126
      ARM; armadillo repeat [structural motif]
      pfam08609
      Location:9 → 95
      Fes1; Nucleotide exchange factor Fes1

    2. NM_001161128.1 → NP_001154600.1  Fes1A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154600.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VC36, A0A384KB34, A0A7G2ENI4, A8MQ87
      Conserved Domains (3) summary
      COG5064
      Location:4 → 212
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:66 → 90
      ARM; armadillo repeat [structural motif]
      pfam08609
      Location:7 → 59
      Fes1; Nucleotide exchange factor Fes1

    3. NM_001337811.1 → NP_001327344.1  Fes1A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VC36, A0A384KB34, A0A7G2ENI4, A8MQ87
      Conserved Domains (3) summary
      COG5064
      Location:4 → 212
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:66 → 90
      ARM; armadillo repeat [structural motif]
      pfam08609
      Location:7 → 59
      Fes1; Nucleotide exchange factor Fes1

    4. NM_001084657.1 → NP_001078126.1  Fes1A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078126.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VC36, A0A384KB34, A0A7G2ENI4, A8MQ87
      Conserved Domains (3) summary
      COG5064
      Location:4 → 212
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:66 → 90
      ARM; armadillo repeat [structural motif]
      pfam08609
      Location:7 → 59
      Fes1; Nucleotide exchange factor Fes1
    Nucleotide Protein
    Heading Accession and Version

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