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    NIP7;1 NOD26-like intrinsic protein 7;1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819783, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NIP7;1
    Official Full Name
    NOD26-like intrinsic protein 7;1
    Primary source
    TAIR:AT3G06100
    Locus tag
    AT3G06100
    See related
    Araport:AT3G06100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F28L1.3; F28L1_3; NLM6; NLM8; NOD26-like intrinsic protein 7;1; NOD26-LIKE MIP 6; NOD26-LIKE MIP 8
    Summary
    Encodes NIP7;1, an anther-specific boric acid transporter of the aquaporin superfamily regulated by an unusual tyrosine in helix 2 of the transport pore.
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    Genomic context

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    See NIP7;1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (1841168..1843196, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene trichome birefringence-like protein (DUF828) Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tRNA-Gly Neighboring gene MAPK phosphatase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nodulin Intrinsic Protein 7;1 Is a Tapetal Boric Acid Channel Involved in Pollen Cell Wall Formation. Routray P, et al. Plant Physiol, 2018 Nov. PMID 30266747, Free PMC Article
    2. Arabidopsis thaliana NIP7;1 is involved in tissue arsenic distribution and tolerance in response to arsenate. Lindsay ER, et al. FEBS Lett, 2016 Mar. PMID 26898223
    3. Arabidopsis thaliana NIP7;1: an anther-specific boric acid transporter of the aquaporin superfamily regulated by an unusual tyrosine in helix 2 of the transport pore. Li T, et al. Biochemistry, 2011 Aug 9. PMID 21710975
    4. The Arabidopsis thaliana aquaglyceroporin AtNIP7;1 is a pathway for arsenite uptake. Isayenkov SV, et al. FEBS Lett, 2008 May 14. PMID 18435919
    5. A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2. Lalonde S, et al. Front Physiol, 2010. PMID 21423366, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors propose that NIP7;1 serves as a gated boric acid channel in developing anthers that aids in the uptake of this critical micronutrient by tapetal cells.
      Title: Nodulin Intrinsic Protein 7;1 Is a Tapetal Boric Acid Channel Involved in Pollen Cell Wall Formation.
    2. Loss of function of NIP7;1 improved tolerance to arsenate and reduced arsenic levels in both the phloem and xylem, resulting in altered arsenic distribution between tissues.
      Title: Arabidopsis thaliana NIP7;1 is involved in tissue arsenic distribution and tolerance in response to arsenate.
    3. NIP7;1 is selectively expressed in developing anther tissues of young floral buds of A. thaliana, principally in developing pollen grains of stage 9-11 anthers; Tyr81 modulates transport and may provide an additional level of regulation
      Title: Arabidopsis thaliana NIP7;1: an anther-specific boric acid transporter of the aquaporin superfamily regulated by an unusual tyrosine in helix 2 of the transport pore.
    4. The data suggest that AtNIP7 can mediate AsIII transport and contributes to AsIII uptake in plants.
      Title: The Arabidopsis thaliana aquaglyceroporin AtNIP7;1 is a pathway for arsenite uptake.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001337632.1
    NM_001337633.1
    NM_111485.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables active borate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables water channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within borate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NOD26-like intrinsic protein 7;1
    NP_566271.1
    • NOD26-like intrinsic protein 7;1 (NIP7;1); FUNCTIONS IN: water channel activity; INVOLVED IN: transport; LOCATED IN: membrane; EXPRESSED IN: 6 plant structures; EXPRESSED DURING: petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Major intrinsic protein, conserved site (InterPro:IPR022357), Major intrinsic protein (InterPro:IPR000425); BEST Arabidopsis thaliana protein match is: NOD26-like intrinsic protein 4;1 (TAIR:AT5G37810.1); Has 10571 Blast hits to 10316 proteins in 2159 species: Archae - 111; Bacteria - 5379; Metazoa - 1383; Fungi - 439; Plants - 2077; Viruses - 4; Other Eukaryotes - 1178 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1841168..1843196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111485.3 → NP_566271.1  NOD26-like intrinsic protein 7;1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566271.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0MEU4, Q1PES9, Q8LAI1, Q9M8K8
      UniProtKB/TrEMBL
      A0A178V7E3, A0A5S9X9W3
      Conserved Domains (1) summary
      PLN00183
      Location:1 → 275
      PLN00183; putative aquaporin NIP7; Provisional

    2. NM_001337632.1 → NP_001327693.1  NOD26-like intrinsic protein 7;1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LT38

    3. NM_001337633.1 → NP_001327692.1  NOD26-like intrinsic protein 7;1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LT37
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LAI1.2

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