RAD51B DNA repair (Rad51) family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RAD51B
Official Full Name: DNA repair (Rad51) family protein
Primary source: TAIR:AT2G28560
Locus tag: AT2G28560
See related: Araport:AT2G28560
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATRAD51B; T17D12.12; T17D12_12
Summary: Encodes a protein of the RAD51B family involved in double stranded DNA repair. Homozygous mutant plants show increased sensitivity to mitomycin which induces DS breaks.
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Genomic context

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See RAD51B in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 14

Sequence:: Chromosome: 2; NC_003071.7 (12235875..12239146, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Notwithstanding their clearly established importance for RAD51-dependent homologous recombination, XRCC2, RAD51B and RAD51D thus also participate in Single-Strand Annealing recombination.
Title: Roles of XRCC2, RAD51B and RAD51D in RAD51-independent SSA recombination.
The genome stability of the Arabidopsis thaliana mutants deficient in ATM (communication between DNA strand break recognition and the repair machinery), KU80 (deficient in NHEJ) and RAD51B (deficient in HR repair) genes, was investigated.
Title: Genome stability of Arabidopsis atm, ku80 and rad51b mutants: somatic and transgenerational responses to stress.
The roles of RAD51B and XRCC2 in recombination are thus not limited to mitotic cells.
Title: Effects of XRCC2 and RAD51B mutations on somatic and meiotic recombination in Arabidopsis thaliana.
Results suggest that AtRAD51B gene product is involved in the repair of double-strand DNA breaks via homologous recombination. [Rad51B]
Title: Arabidopsis Rad51B is important for double-strand DNA breaks repair in somatic cells.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001036361.2

Supported by ESTs:

NM_001124931.1

Supported by ESTs:

NM_001161066.1

Supported by ESTs:

NM_128416.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA strand exchange activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: DNA repair (Rad51) family protein

NP_001031438.1

RAD51B; CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), ATPase, AAA+ type, core (InterPro:IPR003593), DNA recombination and repair protein, RecA-like (InterPro:IPR016467), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: RAS associated with diabetes protein 51C (TAIR:AT2G45280.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_001118403.1

RAD51B; CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), ATPase, AAA+ type, core (InterPro:IPR003593), DNA recombination and repair protein, RecA-like (InterPro:IPR016467), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: RAS associated with diabetes protein 51 (TAIR:AT5G20850.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_001154538.1

RAD51B; CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), ATPase, AAA+ type, core (InterPro:IPR003593), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: homolog of RAD51 D (TAIR:AT1G07745.2); Has 2570 Blast hits to 2570 proteins in 515 species: Archae - 541; Bacteria - 205; Metazoa - 686; Fungi - 429; Plants - 272; Viruses - 16; Other Eukaryotes - 421 (source: NCBI BLink).

NP_180423.3

RAD51B; CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), ATPase, AAA+ type, core (InterPro:IPR003593), DNA recombination and repair protein, RecA-like (InterPro:IPR016467), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: RAS associated with diabetes protein 51C (TAIR:AT2G45280.2); Has 2717 Blast hits to 2715 proteins in 543 species: Archae - 539; Bacteria - 255; Metazoa - 717; Fungi - 449; Plants - 276; Viruses - 18; Other Eukaryotes - 463 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

12235875..12239146 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001336172.1 → NP_001323470.1 DNA repair (Rad51) family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5H793, Q5H794, Q5K4Q0, Q9SK02

UniProtKB/TrEMBL

A0A178VZL1, A0A5S9X2C0, A0A654EYF4

Conserved Domains (1) summary

cd19493
Location:92 → 321

Rad51B; RAD51B recombinase
NM_001336173.1 → NP_001323469.1 DNA repair (Rad51) family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5H793, Q5H794, Q5K4Q0, Q9SK02

UniProtKB/TrEMBL

A0A178VZL1, A0A5S9X2C0, A0A654EYF4

Conserved Domains (1) summary

cd19493
Location:92 → 321

Rad51B; RAD51B recombinase
NM_001036361.2 → NP_001031438.1 DNA repair (Rad51) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001031438.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5H793, Q5H794, Q5K4Q0, Q9SK02

UniProtKB/TrEMBL

A0A178VZL1, A0A5S9X2C0, A0A654EYF4

Conserved Domains (1) summary

cd19493
Location:92 → 321

Rad51B; RAD51B recombinase
NM_001124931.1 → NP_001118403.1 DNA repair (Rad51) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001118403.1

Status: REVIEWED

UniProtKB/TrEMBL

F4IIR6, Q2VTQ5

Conserved Domains (2) summary

pfam08423
Location:33 → 304

Rad51; Rad51

cl21455
Location:52 → 305

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001161066.1 → NP_001154538.1 DNA repair (Rad51) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001154538.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SK02

Conserved Domains (2) summary

COG0468
Location:34 → 226

RecA; RecA/RadA recombinase [Replication, recombination and repair]

cl21455
Location:52 → 240

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_128416.4 → NP_180423.3 DNA repair (Rad51) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180423.3

Status: REVIEWED

UniProtKB/TrEMBL

A0A654EYF4

Conserved Domains (2) summary

pfam08423
Location:65 → 336

Rad51; Rad51

cl21455
Location:84 → 337

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases