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    APL4 Glucose-1-phosphate adenylyltransferase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816697, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APL4
    Official Full Name
    Glucose-1-phosphate adenylyltransferase family protein
    Primary source
    TAIR:AT2G21590
    Locus tag
    AT2G21590
    See related
    Araport:AT2G21590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F2G1.14; F2G1_14
    Summary
    Encodes the large subunit of ADP-glucose pyrophosphorylase, the enzyme which catalyzes the first and limiting step in starch biosynthesis. The large subunit plays a regulatory role whereas the small subunit (ApS) is the catalytic isoform. Four isoforms of the large subunit (ApL1-4) have been described.
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    Genomic context

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    See APL4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Sequence:
    Chromosome: 2; NC_003071.7 (9238296..9242481)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene Ribosomal protein S25 family protein Neighboring gene uncharacterized protein Neighboring gene endoplasmatic reticulum retrieval protein 1B Neighboring gene pectinesterase 11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The different large subunit isoforms of Arabidopsis thaliana ADP-glucose pyrophosphorylase confer distinct kinetic and regulatory properties to the heterotetrameric enzyme. Crevillén P, et al. J Biol Chem, 2003 Aug 1. PMID 12748181
    2. Two Arabidopsis ADP-glucose pyrophosphorylase large subunits (APL1 and APL2) are catalytic. Ventriglia T, et al. Plant Physiol, 2008 Sep. PMID 18614708, Free PMC Article
    3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036314.2
    NM_001335766.1
    NM_001335767.1
    NM_001335768.1
    NM_001335769.1
    NM_127730.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    contributes_to glucose-1-phosphate adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucose-1-phosphate adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in starch biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within starch biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    part_of glucose-1-phosphate adenylyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Glucose-1-phosphate adenylyltransferase family protein
    NP_001031391.1
    • APL4; CONTAINS InterPro DOMAIN/s: ADP-glucose pyrophosphorylase, conserved site (InterPro:IPR005836), Glucose-1-phosphate adenylyltransferase (InterPro:IPR011831), Nucleotidyl transferase (InterPro:IPR005835); BEST Arabidopsis thaliana protein match is: Glucose-1-phosphate adenylyltransferase family protein (TAIR:AT4G39210.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_179753.1
    • APL4; CONTAINS InterPro DOMAIN/s: Glucose-1-phosphate adenylyltransferase (InterPro:IPR011831), ADP-glucose pyrophosphorylase, conserved site (InterPro:IPR005836), Nucleotidyl transferase (InterPro:IPR005835); BEST Arabidopsis thaliana protein match is: Glucose-1-phosphate adenylyltransferase family protein (TAIR:AT4G39210.1); Has 8265 Blast hits to 8149 proteins in 1719 species: Archae - 344; Bacteria - 5333; Metazoa - 20; Fungi - 9; Plants - 1699; Viruses - 0; Other Eukaryotes - 860 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9238296..9242481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335765.1 → NP_001324982.1  Glucose-1-phosphate adenylyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SIK1
      UniProtKB/TrEMBL
      A0A178VYA8, A0A384KNK6, B9DGF8
      Conserved Domains (1) summary
      PLN02241
      Location:88 → 523
      PLN02241; glucose-1-phosphate adenylyltransferase

    2. NM_127730.5 → NP_179753.1  Glucose-1-phosphate adenylyltransferase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179753.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SIK1
      UniProtKB/TrEMBL
      A0A178VYA8, A0A384KNK6, B9DGF8
      Conserved Domains (1) summary
      PLN02241
      Location:88 → 523
      PLN02241; glucose-1-phosphate adenylyltransferase

    3. NM_001335766.1 → NP_001324978.1  Glucose-1-phosphate adenylyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SIK1
      UniProtKB/TrEMBL
      A0A178VYA8, A0A384KNK6, B9DGF8
      Conserved Domains (1) summary
      PLN02241
      Location:88 → 523
      PLN02241; glucose-1-phosphate adenylyltransferase

    4. NM_001036314.2 → NP_001031391.1  Glucose-1-phosphate adenylyltransferase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031391.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SIK1
      UniProtKB/TrEMBL
      A0A178VYA8, A0A384KNK6, B9DGF8
      Conserved Domains (1) summary
      PLN02241
      Location:88 → 523
      PLN02241; glucose-1-phosphate adenylyltransferase

    5. NM_001335767.1 → NP_001324979.1  Glucose-1-phosphate adenylyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SIK1
      UniProtKB/TrEMBL
      A0A178VYA8, A0A384KNK6, B9DGF8
      Conserved Domains (1) summary
      PLN02241
      Location:88 → 523
      PLN02241; glucose-1-phosphate adenylyltransferase

    6. NM_001335768.1 → NP_001324980.1  Glucose-1-phosphate adenylyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SIK1
      UniProtKB/TrEMBL
      A0A178VYA8, A0A384KNK6, B9DGF8
      Conserved Domains (1) summary
      PLN02241
      Location:88 → 523
      PLN02241; glucose-1-phosphate adenylyltransferase

    7. NM_001335769.1 → NP_001324981.1  Glucose-1-phosphate adenylyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SIK1
      UniProtKB/TrEMBL
      A0A178VYA8, A0A384KNK6, B9DGF8
      Conserved Domains (1) summary
      PLN02241
      Location:88 → 523
      PLN02241; glucose-1-phosphate adenylyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SIK1.1

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