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    ICK5 Cyclin-dependent kinase inhibitor family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841386, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ICK5
    Official Full Name
    Cyclin-dependent kinase inhibitor family protein
    Primary source
    TAIR:AT1G49620
    Locus tag
    AT1G49620
    See related
    Araport:AT1G49620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtKRP7; F14J22.14; F14J22_14; ICN6; KIP-RELATED PROTEIN 7; KRP7
    Summary
    Kip-related protein (KRP) gene, encodes CDK (cyclin-dependent kinase) inhibitor (CKI), negative regulator of cell division. A member of seven KRP genes found in Arabidopsis thaliana. Differential expression patterns for distinct KRPs were revealed by in situ hybridization. Binds to D type cyclins and may inhibit cell cycle.
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    Genomic context

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    See ICK5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (18365336..18366744, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box family protein Neighboring gene ncRNA Neighboring gene presequence protease 2 Neighboring gene alpha/beta-Hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental, cytological and transcriptional analysis of autotetraploid Arabidopsis. Li X, et al. Planta, 2012 Aug. PMID 22476290
    2. Multiple mechanisms explain how reduced KRP expression increases leaf size of Arabidopsis thaliana. Sizani BL, et al. New Phytol, 2019 Feb. PMID 30267580
    3. Exploiting cell cycle inhibitor genes of the KRP family to control root-knot nematode induced feeding sites in plants. Coelho RR, et al. Plant Cell Environ, 2017 Jul. PMID 28103637
    4. The Arabidopsis thaliana F-box protein FBL17 is essential for progression through the second mitosis during pollen development. Gusti A, et al. PLoS One, 2009. PMID 19277118, Free PMC Article
    5. A novel WEE1 pathway for replication stress responses. Pan T, et al. Nat Plants, 2021 Feb. PMID 33574575

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Increased embryo and seed size in krp4/6/7 mutants results from seed abortion, presumably reducing resource competition, and that seed size differences contribute to the phenotype of several large-leaf mutants. Results provide a new understanding of the role of cell cycle regulation in leaf development and highlight the contribution of the embryo to the development of leaves after germination in general. [Krp7]
      Title: Multiple mechanisms explain how reduced KRP expression increases leaf size of Arabidopsis thaliana.
    2. KRP7 role in gall maturation and root-knot nematode feeding
      Title: Exploiting cell cycle inhibitor genes of the KRP family to control root-knot nematode induced feeding sites in plants.
    3. ICK1 and ICK5 may be involved in developmental delay and that the suppressed growth under glucose treatment probably resulted from disturbed mitotic and endoreduplication cycle in autotetraploid Arabidopsis.
      Title: Developmental, cytological and transcriptional analysis of autotetraploid Arabidopsis.
    4. Phosphorylation of KRP6 and KRP7 by SNF1-related protein kinase-1 links plant energy homeostasis and cell proliferation.
      Title: Phosphorylation of p27(KIP1) homologs KRP6 and 7 by SNF1-related protein kinase-1 links plant energy homeostasis and cell proliferation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_103850.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Cyclin-dependent kinase inhibitor family protein
    NP_175385.1
    • ICK5; FUNCTIONS IN: cyclin binding, cyclin-dependent protein kinase inhibitor activity; INVOLVED IN: negative regulation of cyclin-dependent protein kinase activity; LOCATED IN: nucleus; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Cyclin-dependent kinase inhibitor (InterPro:IPR003175), Cyclin-dependent kinase inhibitor, plant (InterPro:IPR016701); BEST Arabidopsis thaliana protein match is: KIP-related protein 6 (TAIR:AT3G19150.1); Has 254 Blast hits to 244 proteins in 41 species: Archae - 0; Bacteria - 7; Metazoa - 4; Fungi - 18; Plants - 204; Viruses - 0; Other Eukaryotes - 21 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18365336..18366744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333395.1 → NP_001322045.1  Cyclin-dependent kinase inhibitor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ASU8, A0A7G2E107

    2. NM_001333394.1 → NP_001322046.1  Cyclin-dependent kinase inhibitor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ASS0, A0A7G2E107

    3. NM_103850.2 → NP_175385.1  Cyclin-dependent kinase inhibitor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175385.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94CL9, Q9FX90
      UniProtKB/TrEMBL
      A0A7G2E107
      Conserved Domains (1) summary
      pfam02234
      Location:150 → 189
      CDI; Cyclin-dependent kinase inhibitor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94CL9.2

    Gene LinkOut

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