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    MUR4 NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839942, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MUR4
    Official Full Name
    NAD(P)-binding Rossmann-fold superfamily protein
    Primary source
    TAIR:AT1G30620
    Locus tag
    AT1G30620
    See related
    Araport:AT1G30620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    HIGH SUGAR RESPONSE8; HSR8; MURUS 4; T5I8.7; T5I8_7; UDP-D-XYLOSE 4-EPIMERASE 1; UXE1
    Summary
    encodes a type-II membrane protein that catalyzes 4-epimerization of UDP-D-Xylose to UDP-L-Arabinose in vitro, the nucleotide sugar used by glycosyltransferases in the arabinosylation of cell wall polysaccharides and wall-resident proteoglycans.
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    Genomic context

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    See MUR4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (10854517..10858280)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Subtilase family protein Neighboring gene pentatricopeptide (PPR) repeat-containing protein Neighboring gene Coatomer epsilon subunit Neighboring gene Protein kinase family protein Neighboring gene WRKY DNA-binding protein 14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Signaling from an altered cell wall to the nucleus mediates sugar-responsive growth and development in Arabidopsis thaliana. Li Y, et al. Plant Cell, 2007 Aug. PMID 17693536, Free PMC Article
    2. The biosynthesis of L-arabinose in plants: molecular cloning and characterization of a Golgi-localized UDP-D-xylose 4-epimerase encoded by the MUR4 gene of Arabidopsis. Burget EG, et al. Plant Cell, 2003 Feb. PMID 12566589, Free PMC Article
    3. The mur4 mutant of arabidopsis is partially defective in the de novo synthesis of uridine diphospho L-arabinose. Burget EG, et al. Plant Physiol, 1999 Oct. PMID 10517829, Free PMC Article
    4. Abscisic acid positively regulates l-arabinose metabolism to inhibit seed germination through ABSCISIC ACID INSENSITIVE4-mediated transcriptional promotions of MUR4 in Arabidopsis thaliana. Yan J, et al. New Phytol, 2020 Jan. PMID 31461539
    5. The Mediator complex subunits MED25/PFT1 and MED8 are required for transcriptional responses to changes in cell wall arabinose composition and glucose treatment in Arabidopsis thaliana. Seguela-Arnaud M, et al. BMC Plant Biol, 2015 Sep 5. PMID 26341899, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Abscisic acid positively regulates l-arabinose metabolism to inhibit seed germination through ABSCISIC ACID INSENSITIVE4-mediated transcriptional promotions of MUR4 in Arabidopsis thaliana.
      Title: Abscisic acid positively regulates l-arabinose metabolism to inhibit seed germination through ABSCISIC ACID INSENSITIVE4-mediated transcriptional promotions of MUR4 in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084163.1
    NM_001332913.1
    NM_001332914.1
    NM_001332915.1
    NM_001332916.1
    NM_102799.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables UDP-arabinose 4-epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucose 4-epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-L-arabinose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within arabinose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in capsule polysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within plant-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in Golgi trans cisterna HDA PubMed 

    General protein information

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    Preferred Names
    NAD(P)-binding Rossmann-fold superfamily protein
    NP_001077632.1
    • MURUS 4 (MUR4); FUNCTIONS IN: UDP-arabinose 4-epimerase activity, catalytic activity; INVOLVED IN: plant-type cell wall biogenesis, arabinose biosynthetic process, nucleotide-sugar metabolic process; LOCATED IN: Golgi apparatus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040), UDP-glucose 4-epimerase (InterPro:IPR005886); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT4G20460.1); Has 42706 Blast hits to 42698 proteins in 2964 species: Archae - 775; Bacteria - 25859; Metazoa - 727; Fungi - 574; Plants - 1159; Viruses - 34; Other Eukaryotes - 13578 (source: NCBI BLink).
    NP_001319115.1
    • MURUS 4 (MUR4); FUNCTIONS IN: UDP-arabinose 4-epimerase activity, catalytic activity; INVOLVED IN: plant-type cell wall biogenesis, arabinose biosynthetic process, nucleotide-sugar metabolic process; LOCATED IN: Golgi apparatus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040), UDP-glucose 4-epimerase (InterPro:IPR005886); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT4G20460.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_174350.2
    • MURUS 4 (MUR4); FUNCTIONS IN: UDP-arabinose 4-epimerase activity, catalytic activity; INVOLVED IN: plant-type cell wall biogenesis, arabinose biosynthetic process, nucleotide-sugar metabolic process; LOCATED IN: Golgi apparatus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040), UDP-glucose 4-epimerase (InterPro:IPR005886); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT4G20460.1); Has 42820 Blast hits to 42812 proteins in 2971 species: Archae - 775; Bacteria - 25948; Metazoa - 715; Fungi - 615; Plants - 1158; Viruses - 34; Other Eukaryotes - 13575 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      10854517..10858280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102799.6 → NP_174350.2  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174350.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q570B0, Q8H7B9, Q9SA77
      UniProtKB/TrEMBL
      A0A178WAW9, A0A384K925, B9DGJ1
      Conserved Domains (1) summary
      cd05247
      Location:72 → 403
      UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

    2. NM_001084163.1 → NP_001077632.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077632.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8MR41
      Conserved Domains (2) summary
      cd05247
      Location:71 → 402
      UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
      TIGR01179
      Location:72 → 404
      galE; UDP-glucose-4-epimerase GalE

    3. NM_001332913.1 → NP_001319115.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q570B0, Q8H7B9, Q9SA77
      UniProtKB/TrEMBL
      A0A178WAW9, A0A384K925, B9DGJ1
      Conserved Domains (1) summary
      cd05247
      Location:72 → 403
      UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

    4. NM_001332914.1 → NP_001321845.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q570B0, Q8H7B9, Q9SA77
      UniProtKB/TrEMBL
      A0A178WAW9, A0A384K925, B9DGJ1
      Conserved Domains (1) summary
      cd05247
      Location:72 → 403
      UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

    5. NM_001332915.1 → NP_001321843.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AS43

    6. NM_001332916.1 → NP_001321844.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q570B0, Q8H7B9, Q9SA77
      UniProtKB/TrEMBL
      A0A178WAW9, A0A384K925, B9DGJ1
      Conserved Domains (1) summary
      cd05247
      Location:72 → 403
      UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SA77.1

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