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    UPS5 ureide permease 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839185, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UPS5
    Official Full Name
    ureide permease 5
    Primary source
    TAIR:AT1G26440
    Locus tag
    AT1G26440
    See related
    Araport:AT1G26440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATUPS5; T1K7.19; T1K7_19; ureide permease 5
    Summary
    uptake assays in yeast mutants indicated this splice variant is a cellular importer for allantoin, uracil and xanthine
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    Genomic context

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    See UPS5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (9143937..9146106, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene FAD-binding Berberine family protein Neighboring gene tRNA-Asn Neighboring gene Carbohydrate-binding X8 domain superfamily protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ureide Permease 5 (AtUPS5) Connects Cell Compartments Involved in Ureide Metabolism. Lescano I, et al. Plant Physiol, 2020 Mar. PMID 31862838, Free PMC Article
    2. Comparative studies on Ureide Permeases in Arabidopsis thaliana and analysis of two alternative splice variants of AtUPS5. Schmidt A, et al. Planta, 2006 Nov. PMID 16738859
    3. Allantoin accumulation mediated by allantoinase downregulation and transport by Ureide Permease 5 confers salt stress tolerance to Arabidopsis plants. Lescano CI, et al. Plant Mol Biol, 2016 Jul. PMID 27209043
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ups5 knockout plants under salt stress presented a susceptible phenotype and altered allantoin root-to-shoot content ratios.
      Title: Allantoin accumulation mediated by allantoinase downregulation and transport by Ureide Permease 5 confers salt stress tolerance to Arabidopsis plants.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001036017.1
    NM_001332711.1
    NM_001332712.1
    NM_001332713.1
    NM_001332714.1
    NM_102407.2
    NM_179377.2
    NM_202186.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables allantoin:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uracil transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables xanthine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within allantoin transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within nitrogen compound transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within uracil transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within xanthine transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell plate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ureide permease 5
    NP_001031094.1
    • ureide permease 5 (UPS5); LOCATED IN: endomembrane system; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: ureide permease 2 (TAIR:AT2G03530.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_564246.1
    • ureide permease 5 (UPS5); LOCATED IN: endomembrane system; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: ureide permease 2 (TAIR:AT2G03530.2); Has 249 Blast hits to 246 proteins in 69 species: Archae - 0; Bacteria - 112; Metazoa - 0; Fungi - 0; Plants - 119; Viruses - 0; Other Eukaryotes - 18 (source: NCBI BLink).
    NP_849708.1
    • ureide permease 5 (UPS5); FUNCTIONS IN: xanthine transmembrane transporter activity, uracil transmembrane transporter activity, allantoin uptake transmembrane transporter activity; INVOLVED IN: xanthine transport, uracil transport, allantoin transport; LOCATED IN: endomembrane system; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: ureide permease 2 (TAIR:AT2G03530.2); Has 265 Blast hits to 257 proteins in 70 species: Archae - 0; Bacteria - 125; Metazoa - 0; Fungi - 0; Plants - 116; Viruses - 0; Other Eukaryotes - 24 (source: NCBI BLink).
    NP_973915.1
    • ureide permease 5 (UPS5); FUNCTIONS IN: xanthine transmembrane transporter activity, uracil transmembrane transporter activity, allantoin uptake transmembrane transporter activity; INVOLVED IN: xanthine transport, uracil transport, allantoin transport; LOCATED IN: endomembrane system; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: ureide permease 2 (TAIR:AT2G03530.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      9143937..9146106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202186.3 → NP_973915.1  ureide permease 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973915.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LBT6, Q93Z75, Q9FZC9
      UniProtKB/TrEMBL
      C0Z2W7
      Conserved Domains (1) summary
      pfam07168
      Location:49 → 404
      Ureide_permease; Ureide permease

    2. NM_001332712.1 → NP_001321599.1  ureide permease 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9VXK9, A0A654ED24

    3. NM_001332711.1 → NP_001321598.1  ureide permease 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WMF5, A0A1P8ARD7

    4. NM_001332714.1 → NP_001321600.1  ureide permease 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WMF5, A0A1P8ARD4

    5. NM_179377.2 → NP_849708.1  ureide permease 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849708.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LBT6, Q93Z75, Q9FZC9
      UniProtKB/TrEMBL
      C0Z2W7
      Conserved Domains (1) summary
      pfam07168
      Location:49 → 404
      Ureide_permease; Ureide permease

    6. NM_001332713.1 → NP_001321601.1  ureide permease 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WMF5, A0A1P8ARD4

    7. NM_102407.2 → NP_564246.1  ureide permease 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564246.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9VXK9, A0A654ED24, F4IE73
      Conserved Domains (1) summary
      pfam07168
      Location:49 → 368
      Ureide_permease; Ureide permease

    8. NM_001036017.1 → NP_001031094.1  ureide permease 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031094.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9VXK9, B9DH85
      Conserved Domains (1) summary
      pfam07168
      Location:49 → 342
      Ureide_permease; Ureide permease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93Z75.1

    Gene LinkOut

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