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    LOV1 NB-ARC domain-containing disease resistance protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837635, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LOV1
    Official Full Name
    NB-ARC domain-containing disease resistance protein
    Primary source
    TAIR:AT1G10920
    Locus tag
    AT1G10920
    See related
    Araport:AT1G10920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    LOCUS ORCHESTRATING VICTORIN EFFECTS1; T19D16.16; T19D16_16
    Summary
    Encodes LOV1, a disease susceptibility gene that, paradoxically, is a member of the NBS-LRR resistance gene family. Conditions susceptibility to the fungus Cochliobolus victoriae and victorin-dependent induction of defense-associated proteins. Saturation mutagenesis identified 59 lov mutations that all display reduced susceptibility to vitorin. Mutations in known defense response pathways do not prevent susceptibility to C. victoriae.
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    Genomic context

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    See LOV1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (3644180..3647784, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene arginine/glutamate-rich 1 protein Neighboring gene Phosphatidylinositol-4-phosphate 5-kinase family protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene DNA helicase (RECQl4A) Neighboring gene Protein kinase superfamily protein Neighboring gene transmembrane nine 1 Neighboring gene ferredoxin 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the LOV1-mediated, victorin-induced, cell-death response with virus-induced gene silencing. Gilbert BM, et al. Mol Plant Microbe Interact, 2013 Aug. PMID 23634836
    2. Characterization of natural and induced variation in the LOV1 gene, a CC-NB-LRR gene conferring victorin sensitivity and disease susceptibility in Arabidopsis. Sweat TA, et al. Mol Plant Microbe Interact, 2008 Jan. PMID 18052878
    3. Plant disease susceptibility conferred by a "resistance" gene. Lorang JM, et al. Proc Natl Acad Sci U S A, 2007 Sep 11. PMID 17804803, Free PMC Article
    4. Tricking the guard: exploiting plant defense for disease susceptibility. Lorang J, et al. Science, 2012 Nov 2. PMID 23087001, Free PMC Article
    5. Domain swapping to assess the mechanistic basis of Arabidopsis phototropin 1 receptor kinase activation and endocytosis by blue light. Kaiserli E, et al. Plant Cell, 2009 Oct. PMID 19880798, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results provide evidence that the victorin response mediated by LOV1 is a defense response.
      Title: Characterization of the LOV1-mediated, victorin-induced, cell-death response with virus-induced gene silencing.
    2. in LOV1's absence, victorin inhibits TRX-h5, resulting in compromised defense but not disease by C. victoriae; in LOV1's presence, victorin binding to TRX-h5 activates LOV1 and elicits a resistance-like response that confers disease susceptibility
      Title: Tricking the guard: exploiting plant defense for disease susceptibility.
    3. LONG VEGETATIVE PHASE 1 controls flowering time and cold response in Arabidopsis
      Title: Control of flowering time and cold response by a NAC-domain protein in Arabidopsis.
    4. Photochemical properties of phot1 rely on interactions between LOV1 and LOV2. LOV1 cannot operate as a dark-state repressor, resulting in constitutive receptor autophosphorylation and accelerated internalization from the plasma membrane.
      Title: Domain swapping to assess the mechanistic basis of Arabidopsis phototropin 1 receptor kinase activation and endocytosis by blue light.
    5. The recombinant LOV1 domains of phototropin 1 and phototropin 2 have been crystallized; the crystal of the LOV1 domain of phototropin 1 belongs to the orthorhombic space group P2(1)2(1)2(1)and diffracts X-rays to a resolution of 2.1 angstroms.
      Title: Crystallization and preliminary X-ray diffraction analysis [correction of anaylsis] of the LOV1 domains of phototropin 1 and 2 from Arabidopsis thaliana.
    6. LOV1 may function as a resistance gene to a naturally-occurring pathogen of Arabidopsis.[LOV1]
      Title: Characterization of natural and induced variation in the LOV1 gene, a CC-NB-LRR gene conferring victorin sensitivity and disease susceptibility in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001123794.1
    NM_100967.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to molecule of fungal origin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NB-ARC domain-containing disease resistance protein
    NP_001117266.1
    • LOV1; FUNCTIONS IN: ATP binding; INVOLVED IN: defense response to fungus, response to molecule of fungal origin, defense response; LOCATED IN: cellular_component unknown; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (CC-NBS-LRR class) family (TAIR:AT5G48620.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_172561.2
    • LOV1; FUNCTIONS IN: ATP binding; INVOLVED IN: defense response to fungus, response to molecule of fungal origin, defense response; LOCATED IN: cellular_component unknown; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (CC-NBS-LRR class) family (TAIR:AT5G48620.1); Has 17113 Blast hits to 15625 proteins in 596 species: Archae - 16; Bacteria - 1275; Metazoa - 1625; Fungi - 139; Plants - 13787; Viruses - 0; Other Eukaryotes - 271 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3644180..3647784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331944.1 → NP_001322204.1  NB-ARC domain-containing disease resistance protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AT99

    2. NM_001331943.1 → NP_001322203.1  NB-ARC domain-containing disease resistance protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04093
      UniProtKB/TrEMBL
      A0A5S9TRZ6

    3. NM_001331942.1 → NP_001322205.1  NB-ARC domain-containing disease resistance protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AT99

    4. NM_100967.3 → NP_172561.2  NB-ARC domain-containing disease resistance protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172561.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04093
      UniProtKB/TrEMBL
      A0A5S9TRZ6
      Conserved Domains (3) summary
      sd00033
      Location:462 → 486
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00931
      Location:43 → 337
      NB-ARC; NB-ARC domain
      pfam13191
      Location:40 → 173
      AAA_16; AAA ATPase domain

    5. NM_001123794.1 → NP_001117266.1  NB-ARC domain-containing disease resistance protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001117266.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04093
      UniProtKB/TrEMBL
      A0A5S9TRZ6
      Conserved Domains (3) summary
      sd00033
      Location:462 → 486
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00931
      Location:43 → 337
      NB-ARC; NB-ARC domain
      pfam13191
      Location:40 → 173
      AAA_16; AAA ATPase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04093.3

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