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    Tln2 talin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315776, updated on 9-Dec-2024

    Summary

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    Symbol
    Tln2provided by RGD
    Full Name
    talin 2provided by RGD
    Primary source
    RGD:1565416
    See related
    EnsemblRapid:ENSRNOG00000018373 AllianceGenome:RGD:1565416
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565416
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in cell-cell adhesion and presynaptic actin cytoskeleton organization. Is active in presynapse. Orthologous to human TLN2 (talin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 178.4), Heart (RPKM 100.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tln2 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    63
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (76712112..77133361, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (67830920..68252240, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (73009980..73441536, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene tropomyosin 1 Neighboring gene microRNA 190 Neighboring gene U6 spliceosomal RNA Neighboring gene TATA-box binding protein associated factor 12, pseudogene 1 Neighboring gene uncharacterized LOC100911360

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. Di Paolo G, et al. Nature, 2002 Nov 7. PMID 12422219
    2. Talins and kindlins: partners in integrin-mediated adhesion. Calderwood DA, et al. Nat Rev Mol Cell Biol, 2013 Aug. PMID 23860236, Free PMC Article
    3. CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. Balamuth F, et al. J Immunol, 2004 May 15. PMID 15128768
    4. Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart. Zhang JQ, et al. Biochemistry, 2001 Dec 11. PMID 11732910
    5. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in presynaptic actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fascia adherens ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    talin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419941.1 → NP_001406870.1  talin-2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5Y6H9
      Related
      ENSRNOP00000099929.1, ENSRNOT00000121208.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      76712112..77133361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265537.1 → XP_063121607.1  talin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y6H9, D4A3B0
      Related
      ENSRNOP00000061714.4, ENSRNOT00000064613.6

    2. XM_017596083.2 → XP_017451572.1  talin-2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y6H9
      Conserved Domains (10) summary
      cd12150
      Location:1658 → 1829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:92 → 318
      B41; Band 4.1 homologues
      smart00307
      Location:2299 → 2509
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314 → 405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:208 → 318
      FERM_M; FERM central domain
      pfam08913
      Location:1852 → 1936
      VBS; Vinculin Binding Site
      pfam09141
      Location:496 → 657
      Talin_middle; Talin, middle domain
      pfam09379
      Location:94 → 190
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:6 → 87
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:691 → 767
      I_LWEQ; I/LWEQ domain

    3. XM_017596080.2 → XP_017451569.1  talin-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUI0, A0A8I5Y6H9
      Related
      ENSRNOP00000069105.2, ENSRNOT00000081450.3
      Conserved Domains (10) summary
      cd12150
      Location:1658 → 1829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:92 → 318
      B41; Band 4.1 homologues
      smart00307
      Location:2339 → 2549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314 → 405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:208 → 318
      FERM_M; FERM central domain
      pfam08913
      Location:1852 → 1976
      VBS; Vinculin Binding Site
      pfam09141
      Location:496 → 657
      Talin_middle; Talin, middle domain
      pfam09379
      Location:94 → 190
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:6 → 87
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:691 → 767
      I_LWEQ; I/LWEQ domain

    4. XM_063265536.1 → XP_063121606.1  talin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y6H9

    5. XM_063265535.1 → XP_063121605.1  talin-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUI0, A0A8I5Y6H9

    6. XM_017596082.2 → XP_017451571.1  talin-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUI0, A0A8I5Y6H9
      Conserved Domains (10) summary
      cd12150
      Location:1658 → 1829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:92 → 318
      B41; Band 4.1 homologues
      smart00307
      Location:2339 → 2549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314 → 405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:208 → 318
      FERM_M; FERM central domain
      pfam08913
      Location:1852 → 1976
      VBS; Vinculin Binding Site
      pfam09141
      Location:496 → 657
      Talin_middle; Talin, middle domain
      pfam09379
      Location:94 → 190
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:6 → 87
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:691 → 767
      I_LWEQ; I/LWEQ domain

    7. XM_063265534.1 → XP_063121604.1  talin-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUI0, A0A8I5Y6H9

    8. XM_008766402.4 → XP_008764624.1  talin-2 isoform X1

      See identical proteins and their annotated locations for XP_008764624.1

      UniProtKB/TrEMBL
      A0A0G2JUI0, A0A8I5Y6H9
      Related
      ENSRNOP00000024885.8, ENSRNOT00000024885.9
      Conserved Domains (10) summary
      cd12150
      Location:1658 → 1829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:92 → 318
      B41; Band 4.1 homologues
      smart00307
      Location:2339 → 2549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314 → 405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:208 → 318
      FERM_M; FERM central domain
      pfam08913
      Location:1852 → 1976
      VBS; Vinculin Binding Site
      pfam09141
      Location:496 → 657
      Talin_middle; Talin, middle domain
      pfam09379
      Location:94 → 190
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:6 → 87
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:691 → 767
      I_LWEQ; I/LWEQ domain

    9. XM_008766403.4 → XP_008764625.1  talin-2 isoform X1

      See identical proteins and their annotated locations for XP_008764625.1

      UniProtKB/TrEMBL
      A0A0G2JUI0, A0A8I5Y6H9
      Conserved Domains (10) summary
      cd12150
      Location:1658 → 1829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:92 → 318
      B41; Band 4.1 homologues
      smart00307
      Location:2339 → 2549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314 → 405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:208 → 318
      FERM_M; FERM central domain
      pfam08913
      Location:1852 → 1976
      VBS; Vinculin Binding Site
      pfam09141
      Location:496 → 657
      Talin_middle; Talin, middle domain
      pfam09379
      Location:94 → 190
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:6 → 87
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:691 → 767
      I_LWEQ; I/LWEQ domain

    10. XM_063265538.1 → XP_063121608.1  talin-2 isoform X5

    11. XM_063265539.1 → XP_063121609.1  talin-2 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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