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    Ano9 anoctamin 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499287, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ano9provided by RGD
    Official Full Name
    anoctamin 9provided by RGD
    Primary source
    RGD:1560565
    See related
    EnsemblRapid:ENSRNOG00000015830 AllianceGenome:RGD:1560565
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560565
    Summary
    Predicted to enable chloride channel inhibitor activity; monoatomic ion channel activity; and phospholipid scramblase activity. Predicted to be involved in chloride transmembrane transport. Predicted to act upstream of or within calcium activated phospholipid scrambling and establishment of localization in cell. Predicted to be located in endoplasmic reticulum. Predicted to be active in plasma membrane. Orthologous to human ANO9 (anoctamin 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 26.5), Lung (RPKM 12.7) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ano9 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205638571..205659780, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196208863..196230381, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (213908389..213929291, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 4 Neighboring gene plakophilin 3 Neighboring gene single Ig and TIR domain containing Neighboring gene uncharacterized LOC134485202 Neighboring gene RNA, U6 small nuclear 1205 Neighboring gene uncharacterized LOC102552971 Neighboring gene phosphatidylserine synthase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CFTR and TMEM16A are separate but functionally related Cl- channels. Ousingsawat J, et al. Cell Physiol Biochem, 2011. PMID 22178883
    2. Expression and function of epithelial anoctamins. Schreiber R, et al. J Biol Chem, 2010 Mar 5. PMID 20056604, Free PMC Article
    3. Anoctamins are a family of Ca2+-activated Cl- channels. Tian Y, et al. J Cell Sci, 2012 Nov 1. PMID 22946059
    4. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. Scudieri P, et al. Exp Physiol, 2012 Feb. PMID 21984732
    5. Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. Suzuki J, et al. J Biol Chem, 2013 May 10. PMID 23532839, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables intracellularly calcium-gated chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables intracellularly calcium-gated chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid scramblase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium activated galactosylceramide scrambling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within calcium activated phosphatidylcholine scrambling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within calcium activated phosphatidylserine scrambling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of smell ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    anoctamin 9; anoctamin-9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432459.1 → NP_001419388.1  anoctamin 9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HXP6

    2. NM_001432460.1 → NP_001419389.1  anoctamin 9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6GGP5, A6HXP6

    3. NM_001432461.1 → NP_001419390.1  anoctamin 9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1LY14

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      205638571..205659780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230589.4 → XP_006230651.1  anoctamin-9 isoform X2

      Related
      ENSRNOP00000088896.1, ENSRNOT00000108940.2
      Conserved Domains (2) summary
      pfam04547
      Location:174 → 730
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:35 → 171
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

    2. XM_063281022.1 → XP_063137092.1  anoctamin-9 isoform X1

    3. XM_006230590.4 → XP_006230652.1  anoctamin-9 isoform X4

      Conserved Domains (1) summary
      pfam04547
      Location:30 → 586
      Anoctamin; Calcium-activated chloride channel

    4. XM_017590250.3 → XP_017445739.1  anoctamin-9 isoform X4

      UniProtKB/TrEMBL
      F1LY14
      Conserved Domains (1) summary
      pfam04547
      Location:30 → 586
      Anoctamin; Calcium-activated chloride channel

    5. XM_039094754.2 → XP_038950682.1  anoctamin-9 isoform X3

      UniProtKB/TrEMBL
      F1LY14
      Conserved Domains (1) summary
      pfam04547
      Location:32 → 586
      Anoctamin; Calcium-activated chloride channel
    Nucleotide Protein Strain
    Heading Accession and Version

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