drl derailed [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: drlprovided by FlyBase
Official Full Name: derailedprovided by FlyBase
Primary source: FLYBASE:FBgn0015380
Locus tag: Dmel_CG17348
See related: AllianceGenome:FB:FBgn0015380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10758; CG17348; Dmel\CG17348; Drl; DRL; lin; lio; lio/drl
Summary: Enables several functions, including Wnt receptor activity; Wnt-protein binding activity; and protein dimerization activity. Involved in several processes, including determination of muscle attachment site; learning or memory; and neuron projection guidance. Located in axon; dendrite; and plasma membrane. Part of receptor complex. Is expressed in several structures, including A1-7 lateral transverse muscle cell; anlage in statu nascendi; brain; head epidermis primordium; and synaptic neuropil subdomain. Used to study intellectual disability. Orthologous to human RYK (receptor like tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 37C7-37C7; 2-54 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (19190342..19208621)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (19190342..19208621)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dilp8 and its candidate receptor, Drl, are involved in the transdetermination of the Drosophila imaginal disc.
Title: Dilp8 and its candidate receptor, Drl, are involved in the transdetermination of the Drosophila imaginal disc.
Data observed that Drl is required for the rotation of the DA1/VA1d dendritic pair. Drl is much more highly expressed by the DA1 dendrites than the adjacent VA1d dendrites. Mosaic and epistatic analyses showed that Drl specifically functions in the DA1 dendrites in which it antagonizes the Wnt5-Vang repulsion and mediates the migration of the DA1 glomerulus towards Wnt5.
Title: Interplay between axonal Wnt5-Vang and dendritic Wnt5-Drl/Ryk signaling controls glomerular patterning in the Drosophila antennal lobe.
Wnt5 promotes dendrite termination on the periphery of sternites through the Ryk receptor family kinase Derailed (Drl) and the Rho GTPase guanine nucleotide exchange factor Trio in C4da neurons
Title: Adult Drosophila sensory neurons specify dendritic territories independently of dendritic contacts through the Wnt5-Drl signaling pathway.
Drl promotes dorsolateral targeting of projection neuron dendrites in developing antennal lobe.
Title: Wnt5 and drl/ryk gradients pattern the Drosophila olfactory dendritic map.
Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B in the developing embryonic central nervous system.
Title: Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B.
WNT5 interacts with doughnut and derailed to mediate muscle attachment site selection
Title: WNT5 interacts with the Ryk receptors doughnut and derailed to mediate muscle attachment site selection in Drosophila melanogaster.
Derailed protein receptor (Drl) is localized in developing olfactory glomeruli and mediates Wnt5 signaling.
Title: Differentially expressed Drl and Drl-2 play opposing roles in Wnt5 signaling during Drosophila olfactory system development.
Src family kinases play novel roles in WNT5/Derailed-mediated signaling
Title: Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system.
Wnt5 regulates the growth of the Drosophila neuromuscular junction (NMJ) by signaling through the Derailed receptor. Mutations in both wnt5 and drl result in a significant reduction in the number of synaptic boutons.
Title: Derailed regulates development of the Drosophila neuromuscular junction.
Both the Wnt4-frizzled pathway and a separate Wnt5-derailed pathway are needed for proper salivary gland migration in Drosophila embryogenesis.
Title: Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Wnt receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables Wnt receptor activity	TAS Traceable Author Statement more info	PubMed
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
NOT enables protein kinase activity	IKR Inferred from Key Residues more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	TAS Traceable Author Statement more info	PubMed
involved_in axon midline choice point recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemorepulsion of axon	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chemorepulsion of axon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of muscle attachment site	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in haltere development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	TAS Traceable Author Statement more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: derailed

Names: CG17348-PA; CG17348-PB; drl-PA; drl-PB; linotte; lionette

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

19190342..19208621

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057791.4 → NP_477139.1 derailed, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477139.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27324, Q9U9Y3, Q9VIY6

Related

FBpp0080736

Conserved Domains (3) summary

smart00469
Location:21 → 157

WIF; Wnt-inhibitory factor-1 like domain

cd05043
Location:336 → 606

PTK_Ryk; Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)

pfam07714
Location:343 → 599

Pkinase_Tyr; Protein tyrosine kinase
NM_001273637.1 → NP_001260566.1 derailed, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260566.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PDD9

Conserved Domains (3) summary

smart00469
Location:21 → 157

WIF; Wnt-inhibitory factor-1 like domain

cd05043
Location:336 → 606

PTK_Ryk; Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)

pfam07714
Location:343 → 599

Pkinase_Tyr; Protein tyrosine kinase