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    Xrra1 X-ray radiation resistance associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 446101, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Xrra1provided by MGI
    Official Full Name
    X-ray radiation resistance associated 1provided by MGI
    Primary source
    MGI:MGI:2181647
    See related
    Ensembl:ENSMUSG00000035211 AllianceGenome:MGI:2181647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in response to X-ray. Predicted to be located in cytoplasm and nuclear body. Predicted to be active in nucleus. Orthologous to human XRRA1 (X-ray radiation resistance associated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 88.3), adrenal adult (RPKM 15.3) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Xrra1 in Genome Data Viewer
    Location:
    7 E1- E2; 7 54.15 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99508425..99567031)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99859218..99917824)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily AT member 1 Neighboring gene olfactory receptor enhancer Ikaria Neighboring gene STARR-positive B cell enhancer ABC_E3735 Neighboring gene STARR-seq mESC enhancer starr_19662 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:106976805-106976914 Neighboring gene STARR-positive B cell enhancer ABC_E3736 Neighboring gene neuraminidase 3 Neighboring gene signal peptidase complex subunit 2 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E1347 Neighboring gene predicted gene, 38405 Neighboring gene ring finger protein 169 Neighboring gene predicted gene 5115 Neighboring gene U2 small nuclear RNA auxiliary factor 1-like 4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, genomic characterization and over-expression of a novel gene, XRRA1, identified from human colorectal cancer cell HCT116Clone2_XRR and macaque testis. Mesak FM, et al. BMC Genomics, 2003 Aug 9. PMID 12908878, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to X-ray ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to X-ray ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    X-ray radiation resistance-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164258.1 → NP_001157730.1  X-ray radiation resistance-associated protein 1

      See identical proteins and their annotated locations for NP_001157730.1

      Status: VALIDATED

      Source sequence(s)
      BC151014, BK000542
      Consensus CDS
      CCDS52321.1
      UniProtKB/Swiss-Prot
      B2RX67, Q3U3V8, Q7M740
      UniProtKB/TrEMBL
      A0A991ENW4
      Related
      ENSMUSP00000035929.9, ENSMUST00000036155.10
      Conserved Domains (3) summary
      PRK15370
      Location:237 → 421
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      COG4886
      Location:136 → 276
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:147 → 169
      LRR_1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      99508425..99567031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322345.2 → XP_017177834.1  X-ray radiation resistance-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A991ENW4
      Conserved Domains (3) summary
      PRK15370
      Location:239 → 423
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      COG4886
      Location:138 → 278
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:149 → 171
      LRR_1; leucine-rich repeat [structural motif]

    2. XM_006508007.4 → XP_006508070.1  X-ray radiation resistance-associated protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006508070.1

      UniProtKB/Swiss-Prot
      B2RX67, Q3U3V8, Q7M740
      UniProtKB/TrEMBL
      A0A991ENW4
      Conserved Domains (3) summary
      PRK15370
      Location:237 → 421
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      COG4886
      Location:136 → 276
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:147 → 169
      LRR_1; leucine-rich repeat [structural motif]

    3. XM_017322346.1 → XP_017177835.1  X-ray radiation resistance-associated protein 1 isoform X3

      Related
      ENSMUST00000208449.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U3V8.1 GenPept UniProtKB/Swiss-Prot:Q3U3V8

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