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    Styxl1 serine/threonine/tyrosine interacting-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 76571, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Styxl1provided by MGI
    Official Full Name
    serine/threonine/tyrosine interacting-like 1provided by MGI
    Primary source
    MGI:MGI:1923821
    See related
    Ensembl:ENSMUSG00000019178 AllianceGenome:MGI:1923821
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dusp24; Mkstyx; 1700011C14Rik
    Summary
    Predicted to enable protein phosphatase binding activity; protein phosphatase inhibitor activity; and pseudophosphatase activity. Predicted to be involved in negative regulation of stress granule assembly; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of neuron projection development. Predicted to be active in mitochondrion. Orthologous to human STYXL1 (serine/threonine/tyrosine interacting like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 12.2), ovary adult (RPKM 0.7) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Styxl1 in Genome Data Viewer
    Location:
    5 G2; 5 75.38 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135776074..135807277, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135747220..135778424, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cytochrome p450 oxidoreductase Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_14588 Neighboring gene STARR-positive B cell enhancer ABC_E9654 Neighboring gene transmembrane protein 120A Neighboring gene microRNA 7034 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:136254330-136254517 Neighboring gene predicted gene, 30205 Neighboring gene malate dehydrogenase 2, NAD (mitochondrial) Neighboring gene serine/arginine repetitive matrix 3 Neighboring gene STARR-positive B cell enhancer ABC_E6387

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. STYXL1 regulates CCT complex assembly and flagellar tubulin folding in sperm formation. Chen Y, et al. Nat Commun, 2024 Jan 2. PMID 38168070, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pseudophosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudophosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of stress granule assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine/tyrosine-interacting-like protein 1
    Names
    dual specificity phosphatase 24 (putative)
    map kinase phosphatase-like protein MK-STYX

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289554.1 → NP_001276483.1  serine/threonine/tyrosine-interacting-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_001276483.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
      Source sequence(s)
      AK005599, BC045148
      Consensus CDS
      CCDS19745.2
      UniProtKB/TrEMBL
      Q9DAR2
      Related
      ENSMUSP00000051216.5, ENSMUST00000053906.11
      Conserved Domains (1) summary
      cl28904
      Location:158 → 311
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. NM_001289555.1 → NP_001276484.1  serine/threonine/tyrosine-interacting-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_001276484.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
      Source sequence(s)
      AK005599, BC045148
      Consensus CDS
      CCDS19745.2
      UniProtKB/TrEMBL
      Q9DAR2
      Related
      ENSMUSP00000106793.3, ENSMUST00000111163.9
      Conserved Domains (1) summary
      cl28904
      Location:158 → 311
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    3. NM_001289556.1 → NP_001276485.1  serine/threonine/tyrosine-interacting-like protein 1 isoform c

      See identical proteins and their annotated locations for NP_001276485.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a.
      Source sequence(s)
      AK005858, AK161310, BC045148
      Consensus CDS
      CCDS71679.1
      UniProtKB/TrEMBL
      Q9DAG7
      Related
      ENSMUSP00000106791.3, ENSMUST00000111161.9
      Conserved Domains (1) summary
      cl28904
      Location:14 → 167
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. NM_001289557.1 → NP_001276486.1  serine/threonine/tyrosine-interacting-like protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and lacks two alternate exons, which results in a region containing a frameshift, compared to variant 1. The encoded isoform (b) is shorter than isoform 1.
      Source sequence(s)
      AK161310, BC045148, BF471066
      Consensus CDS
      CCDS71680.1
      UniProtKB/TrEMBL
      D3YZ02
      Related
      ENSMUSP00000106792.2, ENSMUST00000111162.8
      Conserved Domains (1) summary
      cl28904
      Location:103 → 207
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    5. NM_029659.4 → NP_083935.3  serine/threonine/tyrosine-interacting-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_083935.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 encode the same isoform (a).
      Source sequence(s)
      AC083948, AK161310, BC045148
      Consensus CDS
      CCDS19745.2
      UniProtKB/TrEMBL
      Q9DAR2
      Related
      ENSMUSP00000106794.3, ENSMUST00000111164.9
      Conserved Domains (1) summary
      cl28904
      Location:158 → 311
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      135776074..135807277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254884.2 → XP_030110744.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X6

      UniProtKB/TrEMBL
      Q9DAR2
      Related
      ENSMUSP00000135982.2, ENSMUST00000177559.8
      Conserved Domains (1) summary
      cl28904
      Location:158 → 311
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_030254888.2 → XP_030110748.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X11

      UniProtKB/TrEMBL
      Q9DAG7
      Conserved Domains (1) summary
      cl28904
      Location:14 → 167
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    3. XM_006504519.4 → XP_006504582.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X8

      Conserved Domains (1) summary
      cl28904
      Location:119 → 223
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. XM_006504511.3 → XP_006504574.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X4

      Conserved Domains (1) summary
      cl28904
      Location:174 → 327
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    5. XM_017321146.3 → XP_017176635.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

      Conserved Domains (1) summary
      cl28904
      Location:158 → 278
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    6. XM_017321153.3 → XP_017176642.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X10

      Conserved Domains (1) summary
      cl28904
      Location:14 → 134
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    7. XM_017321150.3 → XP_017176639.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

      Conserved Domains (1) summary
      cl28904
      Location:158 → 278
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    8. XM_017321149.3 → XP_017176638.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

      Conserved Domains (1) summary
      cl28904
      Location:158 → 278
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    9. XM_017321151.3 → XP_017176640.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

      Conserved Domains (1) summary
      cl28904
      Location:158 → 278
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    10. XM_017321147.3 → XP_017176636.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

      Conserved Domains (1) summary
      cl28904
      Location:158 → 278
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    11. XM_017321148.3 → XP_017176637.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

      Conserved Domains (1) summary
      cl28904
      Location:158 → 278
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    12. XM_017321145.3 → XP_017176634.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X3

      Conserved Domains (1) summary
      cl28904
      Location:170 → 290
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    13. XM_017321144.3 → XP_017176633.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X2

      Conserved Domains (1) summary
      cl28904
      Location:171 → 291
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    14. XM_017321152.2 → XP_017176641.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X7

      Conserved Domains (1) summary
      cl28904
      Location:119 → 190
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    15. XM_017321143.2 → XP_017176632.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X1

      Conserved Domains (1) summary
      cl28904
      Location:174 → 294
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    16. XM_036165592.1 → XP_036021485.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X9

      UniProtKB/TrEMBL
      J3QK74

    RNA

    1. XR_004942585.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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