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    DLC1 DLC1 Rho GTPase activating protein [ Pan troglodytes (chimpanzee) ]

    Gene ID: 464001, updated on 10-Oct-2024

    Summary

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    Official Symbol
    DLC1provided by VGNC
    Official Full Name
    DLC1 Rho GTPase activating proteinprovided by VGNC
    Primary source
    VGNC:VGNC:13167
    Locus tag
    CK820_G0041535
    See related
    Ensembl:ENSPTRG00000020009
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See DLC1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 7 NC_072405.2 (21339822..21867217, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 8 NC_072406.1 (24928290..25456351, complement)

    Chromosome 7 - NC_072405.2Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U3 Neighboring gene uncharacterized LOC129135845 Neighboring gene uncharacterized LOC107976243 Neighboring gene chromosome 8 C8orf48 homolog Neighboring gene uncharacterized LOC134810824 Neighboring gene zinc finger protein 654-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho GTPase-activating protein 7
    Names
    deleted in liver cancer 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072405.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      21339822..21867217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016959113.4 → XP_016814602.1  rho GTPase-activating protein 7 isoform X1

      UniProtKB/TrEMBL
      A0A2J8K4B9, A0A6D2X7G3, H2QVS0, K7BZB1
      Related
      ENSPTRP00000034252.5
      Conserved Domains (3) summary
      cd08908
      Location:1315 → 1518
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09591
      Location:454 → 513
      SAM_DLC1; SAM domain of DLC1 subfamily
      cd04375
      Location:1072 → 1290
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

    2. XM_016959114.3 → XP_016814603.1  rho GTPase-activating protein 7 isoform X1

      UniProtKB/TrEMBL
      A0A2J8K4B9, A0A6D2X7G3, H2QVS0, K7BZB1
      Conserved Domains (3) summary
      cd08908
      Location:1315 → 1518
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09591
      Location:454 → 513
      SAM_DLC1; SAM domain of DLC1 subfamily
      cd04375
      Location:1072 → 1290
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

    3. XM_016959112.4 → XP_016814601.1  rho GTPase-activating protein 7 isoform X1

      UniProtKB/TrEMBL
      A0A2J8K4B9, A0A6D2X7G3, H2QVS0, K7BZB1
      Conserved Domains (3) summary
      cd08908
      Location:1315 → 1518
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09591
      Location:454 → 513
      SAM_DLC1; SAM domain of DLC1 subfamily
      cd04375
      Location:1072 → 1290
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

    4. XM_054656567.2 → XP_054512542.1  rho GTPase-activating protein 7 isoform X4

      UniProtKB/TrEMBL
      A0A2J8K4C3

    5. XM_016959115.4 → XP_016814604.1  rho GTPase-activating protein 7 isoform X2

      UniProtKB/TrEMBL
      A0A2I3RC10, A0A2I3S289, A0A2J8K4C5, A0A6D2WHD5
      Related
      ENSPTRP00000062181.1
      Conserved Domains (3) summary
      cd08908
      Location:912 → 1115
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09591
      Location:51 → 110
      SAM_DLC1; SAM domain of DLC1 subfamily
      cd04375
      Location:669 → 887
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

    6. XM_063816886.1 → XP_063672956.1  rho GTPase-activating protein 7 isoform X5

    7. XM_016959116.3 → XP_016814605.1  rho GTPase-activating protein 7 isoform X3

      UniProtKB/TrEMBL
      A0A2I3S289, A0A2J8K4C7, A0A6D2WWH4, K7CBG6
      Related
      ENSPTRP00000090541.1
      Conserved Domains (4) summary
      cd08908
      Location:878 → 1081
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09591
      Location:17 → 76
      SAM_DLC1; SAM domain of DLC1 subfamily
      cd04375
      Location:635 → 853
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
      pfam04520
      Location:113 → 188
      Senescence_reg; Senescence regulator

    8. XM_063816885.1 → XP_063672955.1  rho GTPase-activating protein 7 isoform X5

    9. XM_016959117.3 → XP_016814606.1  rho GTPase-activating protein 7 isoform X4

      UniProtKB/TrEMBL
      A0A2I3S289, A0A2J8K4C3
      Conserved Domains (2) summary
      cd08908
      Location:804 → 1007
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd04375
      Location:561 → 779
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

    10. XM_054656571.2 → XP_054512546.1  rho GTPase-activating protein 7 isoform X8

    11. XM_054656569.2 → XP_054512544.1  rho GTPase-activating protein 7 isoform X6

    12. XM_054656570.2 → XP_054512545.1  rho GTPase-activating protein 7 isoform X7

    13. XM_054656568.2 → XP_054512543.1  rho GTPase-activating protein 7 isoform X6

    Nucleotide Protein
    Heading Accession and Version

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