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    hrg-4 Heme transporter hrg-4 [ Caenorhabditis elegans ]

    Gene ID: 185380, updated on 4-Jan-2025

    Summary

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    Official Symbol
    hrg-4
    Official Full Name
    Heme transporter hrg-4
    Primary source
    WormBase:WBGene00009493
    Locus tag
    CELE_F36H1.5
    See related
    AllianceGenome:WB:WBGene00009493
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables heme binding activity and heme transmembrane transporter activity. Involved in heme transport. Located in plasma membrane. Is expressed in intestine. [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See hrg-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (11030143..11030993, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Heme transporter hrg-5 Neighboring gene ncRNA Neighboring gene Heme transporter hrg-6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lifespan regulation by targeting heme signaling in yeast. Patnaik PK, et al. Geroscience, 2024 Oct. PMID 38809391, Free PMC Article
    2. Long-term exposure to polystyrene nanoparticles at environmentally relevant concentration causes suppression in heme homeostasis signal associated with transgenerational toxicity induction in Caenorhabditis elegans. Liu H, et al. J Hazard Mater, 2023 Oct 5. PMID 37499489
    3. Haem transporter HRG-1 is essential in the barber's pole worm and an intervention target candidate. Yang Y, et al. PLoS Pathog, 2023 Jan. PMID 36716341, Free PMC Article
    4. Topologically conserved residues direct heme transport in HRG-1-related proteins. Yuan X, et al. J Biol Chem, 2012 Feb 10. PMID 22174408, Free PMC Article
    5. Iron acquisition and transcriptional regulation. Kaplan CD, et al. Chem Rev, 2009 Oct. PMID 19705827

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heme transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Heme transporter hrg-4
    NP_001129857.1
    • Confirmed by transcript evidence
    NP_001294019.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11030143..11030993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001136385.2 → NP_001129857.1  Heme transporter hrg-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129857.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20106

    2. NM_001307090.4 → NP_001294019.1  Heme transporter hrg-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294019.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A061AD77, B3GWC4, Q20106
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20106.2

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