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    col-99 Cuticle collagen 99;Putative cuticle collagen 99 [ Caenorhabditis elegans ]

    Gene ID: 185112, updated on 9-Dec-2024

    Summary

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    Official Symbol
    col-99
    Official Full Name
    Cuticle collagen 99;Putative cuticle collagen 99
    Primary source
    WormBase:WBGene00000674
    Locus tag
    CELE_F29C4.8
    See related
    AllianceGenome:WB:WBGene00000674
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in axon guidance. Located in extracellular space; neuromuscular junction; and plasma membrane. Part of collagen trimer. Is expressed in anal depressor muscle; body wall musculature; hypodermis; neurons; and retrovesicular ganglion. Human ortholog(s) of this gene implicated in congenital fibrosis of the extraocular muscles 5. Orthologous to human COL23A1 (collagen type XXIII alpha 1 chain) and COL25A1 (collagen type XXV alpha 1 chain). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See col-99 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    19
    Sequence:
    Chromosome: IV; NC_003282.8 (137974..147919, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Mitochondrial cytochrome c oxidase subunit VIc/VIIs domain-containing protein Neighboring gene Cell surface receptor daf-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EGF-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane-associated collagens with interrupted triple-helices (MACITs): evolution from a bilaterian common ancestor and functional conservation in C. elegans. Tu H, et al. BMC Evol Biol, 2015 Dec 14. PMID 26667623, Free PMC Article
    2. Isolation of mutations with dumpy-like phenotypes and of collagen genes in the nematode Pristionchus pacificus. Kenning C, et al. Genesis, 2004 Nov. PMID 15493014
    3. Transmembrane Collagens in Neuromuscular Development and Disorders. Wakabayashi T. Front Mol Neurosci, 2020. PMID 33536873, Free PMC Article
    4. The transmembrane collagen COL-99 guides longitudinally extending axons in C. elegans. Taylor J, et al. Mol Cell Neurosci, 2018 Jun. PMID 29550247
    5. Multiple Pathways Act Together To Establish Asymmetry of the Ventral Nerve Cord in Caenorhabditis elegans. Taylor J, et al. Genetics, 2019 Apr. PMID 30792268, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent conferring tensile strength IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of collagen trimer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of collagen trimer NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of collagen type IV trimer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cuticle collagen 99;Putative cuticle collagen 99
    NP_001122775.2
    • Confirmed by transcript evidence
    NP_001294561.1
    • Confirmed by transcript evidence
    NP_001294562.1
    • Confirmed by transcript evidence
    NP_001294563.1
    • Confirmed by transcript evidence
    NP_001309601.1
    • Confirmed by transcript evidence
    NP_001309602.1
    • Confirmed by transcript evidence
    NP_001309603.1
    • Confirmed by transcript evidence
    NP_001309604.1
    • Confirmed by transcript evidence
    NP_001309605.1
    • Confirmed by transcript evidence
    NP_001309606.1
    • Confirmed by transcript evidence
    NP_001309607.1
    • Confirmed by transcript evidence
    NP_001309608.1
    • Confirmed by transcript evidence
    NP_001309609.1
    • Confirmed by transcript evidence
    NP_001309610.1
    • Confirmed by transcript evidence
    NP_001309611.1
    • Confirmed by transcript evidence
    NP_001309612.1
    • Confirmed by transcript evidence
    NP_499869.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      137974..147919 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067468.7 → NP_499869.3  Putative cuticle collagen 99 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499869.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76368
      Conserved Domains (1) summary
      pfam01391
      Location:362 → 401
      Collagen; Collagen triple helix repeat (20 copies)

    2. NM_001307634.4 → NP_001294563.1  Cuticle collagen 99 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294563.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PRZ7
      Conserved Domains (1) summary
      pfam01391
      Location:362 → 401
      Collagen; Collagen triple helix repeat (20 copies)

    3. NM_001322775.2 → NP_001309601.1  Cuticle collagen 99 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0F6YQF6
      Conserved Domains (1) summary
      pfam01391
      Location:362 → 401
      Collagen; Collagen triple helix repeat (20 copies)

    4. NM_001322764.3 → NP_001309612.1  Cuticle collagen 99 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBK4
      Conserved Domains (1) summary
      pfam01391
      Location:350 → 389
      Collagen; Collagen triple helix repeat (20 copies)

    5. NM_001322765.3 → NP_001309608.1  Cuticle collagen 99 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MAZ6
      Conserved Domains (1) summary
      pfam01391
      Location:350 → 389
      Collagen; Collagen triple helix repeat (20 copies)

    6. NM_001322766.3 → NP_001309610.1  Cuticle collagen 99 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MCG3
      Conserved Domains (1) summary
      pfam01391
      Location:350 → 389
      Collagen; Collagen triple helix repeat (20 copies)

    7. NM_001322767.3 → NP_001309606.1  Cuticle collagen 99 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBL6
      Conserved Domains (1) summary
      pfam01391
      Location:350 → 389
      Collagen; Collagen triple helix repeat (20 copies)

    8. NM_001322768.3 → NP_001309611.1  Cuticle collagen 99 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MD72
      Conserved Domains (1) summary
      pfam01391
      Location:362 → 401
      Collagen; Collagen triple helix repeat (20 copies)

    9. NM_001322769.3 → NP_001309607.1  Cuticle collagen 99 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MB32
      Conserved Domains (1) summary
      pfam01391
      Location:362 → 401
      Collagen; Collagen triple helix repeat (20 copies)

    10. NM_001322770.3 → NP_001309609.1  Cuticle collagen 99 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBJ3
      Conserved Domains (1) summary
      pfam01391
      Location:362 → 401
      Collagen; Collagen triple helix repeat (20 copies)

    11. NM_001322771.3 → NP_001309605.1  Cuticle collagen 99 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MCY1
      Conserved Domains (1) summary
      pfam01391
      Location:362 → 401
      Collagen; Collagen triple helix repeat (20 copies)

    12. NM_001322772.3 → NP_001309604.1  Cuticle collagen 99 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MCS7
      Conserved Domains (1) summary
      pfam01391
      Location:350 → 389
      Collagen; Collagen triple helix repeat (20 copies)

    13. NM_001322773.3 → NP_001309602.1  Cuticle collagen 99 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBJ4
      Conserved Domains (1) summary
      pfam01391
      Location:350 → 389
      Collagen; Collagen triple helix repeat (20 copies)

    14. NM_001322774.3 → NP_001309603.1  Cuticle collagen 99 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBQ9
      Conserved Domains (1) summary
      pfam01391
      Location:350 → 389
      Collagen; Collagen triple helix repeat (20 copies)

    15. NM_001307632.3 → NP_001294561.1  Cuticle collagen 99 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294561.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PC95
      Conserved Domains (1) summary
      pfam01391
      Location:350 → 389
      Collagen; Collagen triple helix repeat (20 copies)

    16. NM_001307633.3 → NP_001294562.1  Cuticle collagen 99 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294562.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PMN6
      Conserved Domains (1) summary
      pfam01391
      Location:362 → 401
      Collagen; Collagen triple helix repeat (20 copies)

    17. NM_001129303.4 → NP_001122775.2  Putative cuticle collagen 99 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122775.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8WIS7, O76368
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76368.4

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