PTGS2 prostaglandin-endoperoxide synthase 2 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: PTGS2provided by VGNC
Official Full Name: prostaglandin-endoperoxide synthase 2provided by VGNC
Primary source: VGNC:VGNC:91959
See related: Ensembl:ENSSSCG00000015579
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: COX2; COX-2; PGHS-2
Expression: Biased expression in lung (RPKM 8.1), spleen (RPKM 2.1) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	9	NC_010451.4 (127850164..127858866, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	9	NC_010451.3 (140251667..140260362, complement)

Chromosome 9 - NC_010451.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ablation of conceptus PTGS2 expression does not alter early conceptus development and establishment of pregnancy in the pigdagger.
Title: Ablation of conceptus PTGS2 expression does not alter early conceptus development and establishment of pregnancy in the pig†.
These findings suggest that nuclear factor kappa B(NF-kappaB) and cyclooxygenase-2 play roles in epidermal cell regeneration following beta-irradiation of mini-pig skin.
Title: β-irradiation (¹⁶⁶Ho patch)-induced skin injury in mini-pigs: effects on NF-κB and COX-2 expression in the skin.
COX2 expression is upregulated in CAVD, and its activity contributes to osteogenic gene induction and valve calcification in vitro and in vivo.
Title: COX2 inhibition reduces aortic valve calcification in vivo.
These results suggest that COX-2 plays a role in the pathogenesis of Mycoplasma hyopneumoniae -infection.
Title: Cyclooxygenase-2 expression in pigs infected experimentally with Mycoplasma hyopneumoniae.
Brain death increases the expression of COX-1 and COX-2 mRNA in the renal medulla
Title: Brain death increases COX-1 and COX-2 expression in the renal medulla in a pig model.
COC-2 inhibitors did not decrease collateral-dependent blood flow to the myocardium in a model of chronic myocardial ischemia.
Title: Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on ischemic myocardium.
COX-2 is differentially expressed in normal versus lungworm-infected lungs of pigs and is likely to be involved in the pathogenesis of porcine parasitic bronchopneumonia.
Title: 5-lipoxygenase and cyclooxygenase-2 in porcine parasitic bronchopneumonia: immunohistochemical and biochemical investigations.
In porcine vas deferens epithelial cell monolayers, increases in anion secretion were associated with preferential upregulation of PTGS2 at the mRNA and protein levels.
Title: Testosterone upregulates anion secretion across porcine vas deferens epithelia in vitro.
myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP
Title: Short-term myocardial ischemia induces cardiac modified C-reactive protein expression and proinflammatory gene (cyclo-oxygenase-2, monocyte chemoattractant protein-1, and tissue factor) upregulation in peripheral blood mononuclear cells.
expression appears to be positively and negatively regulated by p38 MAPK and JNK pathways; alternatively, ERK1/2 appear to be involved in COX-2-independent reparative events that remain to be defined
Title: Mitogen-activated protein kinases regulate COX-2 and mucosal recovery in ischemic-injured porcine ileum.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables prostaglandin-endoperoxide synthase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cyclooxygenase pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: prostaglandin G/H synthase 2

Names: cyclooxygenase-2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

NP_999486.1

EC 1.14.99.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214321.1 → NP_999486.1 prostaglandin G/H synthase 2 precursor

See identical proteins and their annotated locations for NP_999486.1

Status: PROVISIONAL

Source sequence(s)

AY028583

UniProtKB/TrEMBL

A0A286ZV73, A0A4X1TM21, A0A8D0V796, Q8SPR3

Related

ENSSSCP00000035355.1, ENSSSCT00000033304.4

Conserved Domains (2) summary

cd09816
Location:75 → 562

prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

pfam00008
Location:21 → 53

EGF; EGF-like domain