Lin28a lin-28 homolog A [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Lin28aprovided by RGD
Full Name: lin-28 homolog Aprovided by RGD
Primary source: RGD:1566408
See related: EnsemblRapid:ENSRNOG00000082489 AllianceGenome:RGD:1566408
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lin28; RGD1566408
Summary: Predicted to enable RNA binding activity; protein-RNA adaptor activity; and translation initiation factor binding activity. Predicted to be involved in several processes, including RNA metabolic process; positive regulation of intracellular signal transduction; and regulation of gene expression. Predicted to act upstream of or within several processes, including miRNA metabolic process; negative regulation of glial cell differentiation; and regulation of gene expression. Predicted to be located in several cellular components, including cytoplasmic ribonucleoprotein granule; nucleolus; and rough endoplasmic reticulum. Predicted to be active in cytoplasm and nucleus. Orthologous to human LIN28A (lin-28 homolog A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 3.2), Testes (RPKM 1.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (151510891..151527884, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (146227119..146244122, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (152230343..152247873, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-188-5p silencing improves cerebral ischemia/reperfusion injury by targeting Lin28a.
Title: miR-188-5p silencing improves cerebral ischemia/reperfusion injury by targeting Lin28a.
Lin28A alleviates ovariectomy-induced osteoporosis through activation of the AMP-activated protein kinase pathway in rats.
Title: Lin28A alleviates ovariectomy-induced osteoporosis through activation of the AMP-activated protein kinase pathway in rats.
Lin28a ameliorates glucotoxicity-induced beta-cell dysfunction and apoptosis.
Title: Lin28a ameliorates glucotoxicity-induced β-cell dysfunction and apoptosis.
Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells.
Title: Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells.
Lin28a up-regulation is associated with the formation of restenosis via promoting proliferation and migration of vascular smooth muscle cells.
Title: Lin28a up-regulation is associated with the formation of restenosis via promoting proliferation and migration of vascular smooth muscle cells.
results suggested that LIN28 may be involved in the pathologic process of spinal cord injuries
Title: LIN28 expression in rat spinal cord after injury.

Submit: New GeneRIF Correction

General gene information

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Markers

RH125543 (e-PCR)
- UniSTS:162358

BE108055 (e-PCR)
- UniSTS:247607

RH137902 (e-PCR)
- UniSTS:219989

BE113056 (e-PCR)
- UniSTS:246622

AU049987 (e-PCR)
- UniSTS:146429

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-quadruplex RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables pre-miRNA binding	ISO Inferred from Sequence Orthology more info
enables protein-RNA adaptor activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific mRNA binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA 3' uridylation	ISO Inferred from Sequence Orthology more info
involved_in RNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within germ cell development	ISO Inferred from Sequence Orthology more info
involved_in miRNA catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within miRNA metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of glial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of pre-miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell proliferation involved in kidney development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytoplasmic translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in pre-miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pre-miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in pre-miRNA processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of miRNA-mediated gene silencing	ISO Inferred from Sequence Orthology more info
involved_in stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in stem cell population maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in rough endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein lin-28 homolog A

Names: protein lin-28 homolog A-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109269.1 → NP_001102739.1 protein lin-28 homolog A

See identical proteins and their annotated locations for NP_001102739.1

Status: PROVISIONAL

Source sequence(s)

CH473968

UniProtKB/TrEMBL

A6ISZ6, D3ZZA6

Related

ENSRNOP00000108329.1, ENSRNOT00000141154.1

Conserved Domains (2) summary

COG5082
Location:120 → 183

AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

pfam00313
Location:42 → 112

CSD; 'Cold-shock' DNA-binding domain