foxh1 forkhead box H1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: foxh1provided by Xenbase
Official Full Name: forkhead box H1provided by Xenbase
Primary source: Xenbase:XB-GENE-1194372
See related: Ensembl:ENSXETG00000020879 AllianceGenome:Xenbase:XB-GENE-1194372
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: fast1; fast-1; foxh1a; xfast1; xfoxh1; XFast-1
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription cis-regulatory region binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within activin receptor signaling pathway and cellular response to cytokine stimulus. Predicted to be located in nucleus. Predicted to be part of activin responsive factor complex. Is expressed in mesoderm. Orthologous to human FOXH1 (forkhead box H1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 6

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	6	NC_030682.2 (152143072..152157886)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	Unplaced Scaffold	NW_016683476.1 (23641..36822, complement)

Chromosome 6 - NC_030682.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Foxh1 functions at the top of a hierarchy of interactions by marking developmental genes for activation, beginning with the onset of zygotic gene expression.
Title: Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program.
We report a comprehensive genome-wide interaction between Foxh1 and Smad2/3 in mediating Nodal signaling during vertebrate mesendoderm development.
Title: Genome-wide view of TGFβ/Foxh1 regulation of the early mesendoderm program.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables SMAD binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within activin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to cytokine stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within gastrulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of activin responsive factor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: forkhead box protein H1

Names: forkhead activin signal transducer 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017084.1 → NP_001017084.1 forkhead box protein H1

Status: PROVISIONAL

Source sequence(s)

CR761447

UniProtKB/Swiss-Prot

Q28GC4

UniProtKB/TrEMBL

A0A6I8RY33

Related

ENSXETP00000045081.2, ENSXETT00000045081.4

Conserved Domains (1) summary

cd00059
Location:110 → 188

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030682.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

152143072..152157886

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_012953921.3 → XP_012809375.1 forkhead box protein H1 isoform X1

UniProtKB/TrEMBL

A0A6I8RY33, F6UWI4

Conserved Domains (1) summary

cd00059
Location:110 → 188

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
XM_012953919.3 → XP_012809373.1 forkhead box protein H1 isoform X1

UniProtKB/TrEMBL

A0A6I8RY33, F6UWI4

Related

ENSXETP00000087603.2, ENSXETT00000097620.2

Conserved Domains (1) summary

cd00059
Location:110 → 188

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...