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    Suox sulfite oxidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81805, updated on 27-Nov-2024

    Summary

    Official Symbol
    Suoxprovided by RGD
    Official Full Name
    sulfite oxidaseprovided by RGD
    Primary source
    RGD:619994
    See related
    EnsemblRapid:ENSRNOG00000005987 AllianceGenome:RGD:619994
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables heme binding activity; molybdopterin cofactor binding activity; and sulfite oxidase activity. Involved in response to nutrient. Predicted to be located in mitochondrial intermembrane space. Predicted to be active in mitochondrion. Biomarker of steatotic liver disease. Human ortholog(s) of this gene implicated in inherited metabolic disorder and isolated sulfite oxidase deficiency. Orthologous to human SUOX (sulfite oxidase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 42.9), Kidney (RPKM 39.5) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Suox in Genome Data Viewer
    Location:
    7q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1687666..1691759, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (1103149..1107156, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (3098228..3102179, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene prefoldin subunit 1, pseudogene 1 Neighboring gene ribosomal protein S26 Neighboring gene IKAROS family zinc finger 4 Neighboring gene RAB5B, member RAS oncogene family Neighboring gene uncharacterized LOC120093528 Neighboring gene cyclin dependent kinase 2 Neighboring gene premelanosome protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molybdenum ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molybdopterin cofactor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molybdopterin cofactor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molybdopterin cofactor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sulfite oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sulfite oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sulfite oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in response to nutrient IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sulfur compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sulfur compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    sulfite oxidase, mitochondrial
    NP_112389.3
    XP_006240864.1
    XP_006240865.1
    XP_063120370.1
    XP_063120371.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031127.4NP_112389.3  sulfite oxidase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_112389.3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q07116, Q6P6W0
      UniProtKB/TrEMBL
      A6KSG5, G3V6R5
      Related
      ENSRNOP00000008018.3, ENSRNOT00000008018.7
      Conserved Domains (3) summary
      PLN00177
      Location:169544
      PLN00177; sulfite oxidase; Provisional
      cd02111
      Location:186544
      eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
      pfam00173
      Location:85161
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1687666..1691759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240802.5XP_006240864.1  sulfite oxidase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006240864.1

      UniProtKB/Swiss-Prot
      Q07116, Q6P6W0
      UniProtKB/TrEMBL
      A6KSG5, G3V6R5
      Conserved Domains (3) summary
      PLN00177
      Location:169544
      PLN00177; sulfite oxidase; Provisional
      cd02111
      Location:186544
      eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
      pfam00173
      Location:85161
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    2. XM_006240803.5XP_006240865.1  sulfite oxidase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006240865.1

      UniProtKB/Swiss-Prot
      Q07116, Q6P6W0
      UniProtKB/TrEMBL
      A6KSG5, G3V6R5
      Conserved Domains (3) summary
      PLN00177
      Location:169544
      PLN00177; sulfite oxidase; Provisional
      cd02111
      Location:186544
      eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
      pfam00173
      Location:85161
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    3. XM_063264301.1XP_063120371.1  sulfite oxidase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A6KSG5, G3V6R5
    4. XM_063264300.1XP_063120370.1  sulfite oxidase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A6KSG5, G3V6R5