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    HSPBP1 HSPA (Hsp70) binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 23640, updated on 27-Nov-2024

    Summary

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    Official Symbol
    HSPBP1provided by HGNC
    Official Full Name
    HSPA (Hsp70) binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:24989
    See related
    Ensembl:ENSG00000133265 MIM:612939; AllianceGenome:HGNC:24989
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FES1
    Summary
    Enables molecular sequestering activity and ubiquitin protein ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and positive regulation of protein ubiquitination. Is active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 7.8), kidney (RPKM 7.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HSPBP1 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55262223..55280383, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58356168..58375917, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55773591..55791751, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6 regulatory subunit 1 Neighboring gene microRNA 6802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15079 Neighboring gene microRNA 6803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15081 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15084 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:55768465-55768658 Neighboring gene Sharpr-MPRA regulatory region 13763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55781781-55782280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55789069-55789569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11021 Neighboring gene BR serine/threonine kinase 1 Neighboring gene Sharpr-MPRA regulatory region 11129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55824387-55824912 Neighboring gene transmembrane protein 150B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55849388-55850162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55850163-55850936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55855204-55856008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55856009-55856814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55858005-55858699 Neighboring gene lysine methyltransferase 5C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of Hsp70 in tumor cells. Tanimura S, et al. J Biol Chem, 2007 Dec 7. PMID 17855353
    2. HspBP1 and anti-HspBP1 levels in the serum of HIV-infected individuals are associated to the disease progression. Ceccin ADF, et al. J Appl Microbiol, 2019 Aug. PMID 30786116
    3. The Co-Chaperone HspBP1 Is a Novel Component of Stress Granules that Regulates Their Formation. Mahboubi H, et al. Cells, 2020 Mar 29. PMID 32235396, Free PMC Article
    4. HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression. Chaudhary P, et al. Nucleic Acids Res, 2016 Feb 29. PMID 26538602, Free PMC Article
    5. Effect of disulfide crosslinking on thermal transitions and chaperone-like activity of human small heat shock protein HspB1. Chalova AS, et al. Cell Stress Chaperones, 2014 Nov. PMID 24898092, Free PMC Article

    See all (118) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells.
      Title: HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells.
    2. HSPBP1 facilitates cellular RLR-mediated antiviral response by inhibiting the K48-linked ubiquitination of RIG-I.
      Title: HSPBP1 facilitates cellular RLR-mediated antiviral response by inhibiting the K48-linked ubiquitination of RIG-I.
    3. The Co-Chaperone HspBP1 Is a Novel Component of Stress Granules that Regulates Their Formation.
      Title: The Co-Chaperone HspBP1 Is a Novel Component of Stress Granules that Regulates Their Formation.
    4. Circulating HspBp1 is associated with progression of HIV infection and can be used as a new marker to predict the prognosis and management of HIV infection
      Title: HspBP1 and anti-HspBP1 levels in the serum of HIV-infected individuals are associated to the disease progression.
    5. Findings indicate a critical role of HspBP1 in differential CHIP/Hsp70 activities in neuronal and glial cells and the greater neuronal vulnerability to misfolded proteins in neurodegenerative diseases.
      Title: Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins.
    6. downregulation of Hsp70 and HspBP1 represents a unique feature of patients with preterm prelabor rupture of membranes
      Title: Expression profile of heat shock proteins in placental tissues of patients with preterm prelabor rupture of membranes and spontaneous preterm labor with intact membranes.
    7. our results clearly show that HspBP1 acts as an endogenous negative regulator of HIV-1 gene-expression and replication by suppressing NF-kappaB-mediated activation of viral transcription.
      Title: HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression.
    8. Oxidative stress, inducing formation of disulfide bond, can affect stability and conformational mobility of human HspB1.
      Title: Effect of disulfide crosslinking on thermal transitions and chaperone-like activity of human small heat shock protein HspB1.
    9. BAG-1M and HspBP1 had differential impacts on the dynamic composition of steroid receptor folding complexes
      Title: Hsp70 cochaperones HspBP1 and BAG-1M differentially regulate steroid hormone receptor function.
    10. shown that HspBP1 binds Tag7 in the conditioned medium of tumor CSML0 cells, thereby preventing formation of the cytotoxic Tag7-Hsp70 complex
      Title: Extracellular HspBP1 inhibits formation of a cytotoxic Tag7-Hsp70 complex in vitro and in human serum.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables molecular sequestering activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein folding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hsp70-binding protein 1
    Names
    HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
    heat shock protein-binding protein 1
    hsp70 interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130106.2 → NP_001123578.1  hsp70-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001123578.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AB020592, AF217996, BM853303, BU630679
      Consensus CDS
      CCDS33111.1
      UniProtKB/Swiss-Prot
      B3KQP0, B4DG11, O95351, Q6ZNU5, Q9NZL4
      Related
      ENSP00000255631.4, ENST00000255631.9
      Conserved Domains (2) summary
      sd00043
      Location:88 → 130
      ARM; armadillo repeat [structural motif]
      pfam08609
      Location:45 → 139
      Fes1; Nucleotide exchange factor Fes1

    2. NM_001297600.2 → NP_001284529.1  hsp70-binding protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longer isoform (1).
      Source sequence(s)
      AB020592, AF217996, AI859141, AK294358, DB500673
      UniProtKB/Swiss-Prot
      Q9NZL4
      Related
      ENSP00000467574.1, ENST00000587922.5
      Conserved Domains (3) summary
      cd00020
      Location:248 → 347
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam08609
      Location:91 → 185
      Fes1; Nucleotide exchange factor Fes1
      sd00043
      Location:134 → 176
      ARM; armadillo repeat [structural motif]

    3. NM_012267.5 → NP_036399.3  hsp70-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_036399.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AB020592, BM853303, BU630679
      Consensus CDS
      CCDS33111.1
      UniProtKB/Swiss-Prot
      B3KQP0, B4DG11, O95351, Q6ZNU5, Q9NZL4
      Related
      ENSP00000398244.1, ENST00000433386.7
      Conserved Domains (2) summary
      sd00043
      Location:88 → 130
      ARM; armadillo repeat [structural motif]
      pfam08609
      Location:45 → 139
      Fes1; Nucleotide exchange factor Fes1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      55262223..55280383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526691.2 → XP_011524993.1  hsp70-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011524993.1

      Conserved Domains (2) summary
      sd00043
      Location:88 → 130
      ARM; armadillo repeat [structural motif]
      pfam08609
      Location:45 → 139
      Fes1; Nucleotide exchange factor Fes1

    2. XM_024451436.2 → XP_024307204.1  hsp70-binding protein 1 isoform X1

      Conserved Domains (2) summary
      sd00043
      Location:88 → 130
      ARM; armadillo repeat [structural motif]
      pfam08609
      Location:45 → 139
      Fes1; Nucleotide exchange factor Fes1

    3. XM_017026544.3 → XP_016882033.1  hsp70-binding protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B3KQP0, B4DG11, O95351, Q6ZNU5, Q9NZL4
      Conserved Domains (2) summary
      sd00043
      Location:88 → 130
      ARM; armadillo repeat [structural motif]
      pfam08609
      Location:45 → 139
      Fes1; Nucleotide exchange factor Fes1

    4. XM_005258701.4 → XP_005258758.1  hsp70-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005258758.1

      Conserved Domains (2) summary
      sd00043
      Location:88 → 130
      ARM; armadillo repeat [structural motif]
      pfam08609
      Location:45 → 139
      Fes1; Nucleotide exchange factor Fes1

    5. XM_024451437.2 → XP_024307205.1  hsp70-binding protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B3KQP0, B4DG11, O95351, Q6ZNU5, Q9NZL4
      Conserved Domains (2) summary
      sd00043
      Location:88 → 130
      ARM; armadillo repeat [structural motif]
      pfam08609
      Location:45 → 139
      Fes1; Nucleotide exchange factor Fes1

    6. XM_017026545.2 → XP_016882034.1  hsp70-binding protein 1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      58356168..58375917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320424.1 → XP_054176399.1  hsp70-binding protein 1 isoform X1

    2. XM_054320426.1 → XP_054176401.1  hsp70-binding protein 1 isoform X1

    3. XM_054320428.1 → XP_054176403.1  hsp70-binding protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B3KQP0, B4DG11, O95351, Q6ZNU5, Q9NZL4

    4. XM_054320425.1 → XP_054176400.1  hsp70-binding protein 1 isoform X1

    5. XM_054320427.1 → XP_054176402.1  hsp70-binding protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B3KQP0, B4DG11, O95351, Q6ZNU5, Q9NZL4

    6. XM_054320429.1 → XP_054176404.1  hsp70-binding protein 1 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NZL4.2 GenPept UniProtKB/Swiss-Prot:Q9NZL4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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