wg Wnt family member 1 wingless [Tribolium castaneum (red flour beetle)] - Gene

Summary

Gene symbol: wg
Gene description: Wnt family member 1 wingless
Locus tag: TcasGA2_TC014084
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Tribolium castaneum
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia; Tenebrionidae; Tenebrionidae incertae sedis; Tribolium
Also known as: Wnt1
Orthologs: fruit fly all
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Genomic context

Location:: chromosome: 5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_04	current	icTriCast1.1 (GCF_031307605.1)	5	NC_087398.1 (9825151..9833416, complement)
103	previous assembly	Tcas5.2 (GCF_000002335.3)	Linkage Group LG5	NC_007420.3 (5504736..5512407)

Chromosome 5 - NC_087398.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study demonstrates separable functions of Tribolium wg in distal and in ventral leg development- the distal role affects all podomeres distal to the coxa, whereas the ventral role is restricted to cells along the ventral midline of the legs.
Title: Separable functions of wingless in distal and ventral patterning of the Tribolium leg.
Although orthologs of some Drosophila pair-rule genes are not required for proper segmentation in Tribolium, segmental expression of Tc-en and Tc-wg is conserved
Title: Genetic regulation of engrailed and wingless in Tribolium segmentation and the evolution of pair-rule segmentation.
RNAi used to examine the functions of wingless (wg) and dpp in Tribolium embryogenesis, and particularly to assess whether their roles in axis patterning and limb allocation are conserved.
Title: The roles of wingless and decapentaplegic in axis and appendage development in the red flour beetle, Tribolium castaneum.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables frizzled binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell fate commitment	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: wingless

Names: AUGUSTUS-3.0.2_14084; GLEAN_14084

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114350.1 → NP_001107822.1 wingless precursor

Status: VALIDATED

Source sequence(s)

JANKOB010000005

Conserved Domains (1) summary

pfam00110
Location:78 → 428

wnt; wnt family

RefSeqs of Annotated Genomes: GCF_031307605.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference icTriCast1.1 Primary Assembly

Genomic

NC_087398.1 Reference icTriCast1.1 Primary Assembly

Range

9825151..9833416 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008194940.3 → XP_008193162.1 wingless isoform X1

UniProtKB/TrEMBL

D6WK66

Conserved Domains (1) summary

pfam00110
Location:65 → 415

wnt; wnt family