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    TUSC7 tumor suppressor candidate 7 [ Homo sapiens (human) ]

    Gene ID: 285194, updated on 27-Nov-2024

    Summary

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    Official Symbol
    TUSC7provided by HGNC
    Official Full Name
    tumor suppressor candidate 7provided by HGNC
    Primary source
    HGNC:HGNC:27701
    See related
    Ensembl:ENSG00000243197 MIM:616057; AllianceGenome:HGNC:27701
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LSAMPAS3; LINC00902; LSAMP-AS1; LSAMP-AS3; NCRNA00295
    Expression
    Restricted expression toward testis (RPKM 5.6) See more
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    Genomic context

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    See TUSC7 in Genome Data Viewer
    Location:
    3q13.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (116709779..116717036)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (119429675..119436932)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (116428626..116435883)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 582, pseudogene Neighboring gene basic leucine zipper and W2 domains 1 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:116567636-116568270 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:116568271-116568906 Neighboring gene microRNA 4447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14622 Neighboring gene long intergenic non-protein coding RNA 901

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Decreased expression of long non-coding LOC285194 predicts tumour progression and poor prognosis of hepatocellular carcinoma after curative hepatectomy. Qiu J, et al. Postgrad Med J, 2020 Feb. PMID 31494574
    2. Long non-coding RNA TUSC7 expression is independently predictive of outcome in glioma. Ma XL, et al. Eur Rev Med Pharmacol Sci, 2017 Aug. PMID 28925483
    3. The Novel Long Noncoding RNA TUSC7 Inhibits Proliferation by Sponging MiR-211 in Colorectal Cancer. Xu J, et al. Cell Physiol Biochem, 2017. PMID 28214867
    4. Long Non-coding RNA TUSC7, a Target of miR-23b, Plays Tumor-Suppressing Roles in Human Gliomas. Shang C, et al. Front Cell Neurosci, 2016. PMID 27766072, Free PMC Article
    5. Long non-coding RNA tumor suppressor candidate 7 functions as a tumor suppressor and inhibits proliferation in osteosarcoma. Cong M, et al. Tumour Biol, 2016 Jul. PMID 26781978

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Proposed TUSC7/miR-211/Nurr1 ceRNET Might Potentially be Disturbed by a cer-SNP rs2615499 in Breast Cancer.
      Title: A Proposed TUSC7/miR-211/Nurr1 ceRNET Might Potentially be Disturbed by a cer-SNP rs2615499 in Breast Cancer.
    2. Long non-coding RNA TUSC7 suppressed colorectal cancer progression via regulation of miR-23b/PDE7A Axis.
      Title: Long non-coding RNA TUSC7 suppressed colorectal cancer progression via regulation of miR-23b/PDE7A Axis.
    3. LOC285194 inhibits proliferation of human keratinocytes through regulating miR-616/GATA3 pathway.
      Title: LOC285194 inhibits proliferation of human keratinocytes through regulating miR-616/GATA3 pathway.
    4. lncRNA TUSC7 inhibits osteosarcoma progression through the miR181a/RASSF6 axis.
      Title: lncRNA TUSC7 inhibits osteosarcoma progression through the miR‑181a/RASSF6 axis.
    5. Downregulation of long noncoding RNA TUSC7 promoted cell growth, invasion and migration through sponging with miR-616-5p/GSK3beta pathway in ovarian cancer.
      Title: Downregulation of long noncoding RNA TUSC7 promoted cell growth, invasion and migration through sponging with miR-616-5p/GSK3β pathway in ovarian cancer.
    6. LncRNA LOC285194 modulates gastric carcinoma progression through activating Wnt/beta-catenin signaling pathway.
      Title: LncRNA LOC285194 modulates gastric carcinoma progression through activating Wnt/β-catenin signaling pathway.
    7. Decreased expression of long non-coding LOC285194 predicts tumour progression and poor prognosis of hepatocellular carcinoma after curative hepatectomy.
      Title: Decreased expression of long non-coding LOC285194 predicts tumour progression and poor prognosis of hepatocellular carcinoma after curative hepatectomy.
    8. Long non-coding RNA LOC285194 in cancer.
      Title: Long non-coding RNA LOC285194 in cancer.
    9. Long non-coding RNA TUSC7 suppresses osteosarcoma by targeting miR-211.
      Title: Long non-coding RNA TUSC7 suppresses osteosarcoma by targeting miR-211.
    10. [Serum level of lncRNA TUSC7 in patients with esophageal squamous cell carcinoma and its role in promoting tumor cell migration and invasion].
      Title: [Serum level of lncRNA TUSC7 in patients with esophageal squamous cell carcinoma and its role in promoting tumor cell migration and invasion].
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • LSAMP antisense RNA 3 (non-protein coding)
    • tumor suppressor candidate 7 (non-protein coding)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_015391.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108687, AC108713
      Related
      ENST00000496242.7

    2. NR_186111.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108687, AC108713

    3. NR_186112.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108687, AC108713

    4. NR_186113.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108687, AC108713

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      116709779..116717036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      119429675..119436932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials