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    ARHGAP15 Rho GTPase activating protein 15 [ Homo sapiens (human) ]

    Gene ID: 55843, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ARHGAP15provided by HGNC
    Official Full Name
    Rho GTPase activating protein 15provided by HGNC
    Primary source
    HGNC:HGNC:21030
    See related
    Ensembl:ENSG00000075884 MIM:610578; AllianceGenome:HGNC:21030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BM046
    Summary
    RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in lymph node (RPKM 10.3), bone marrow (RPKM 9.8) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARHGAP15 in Genome Data Viewer
    Location:
    2q22.2-q22.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (143129419..143768352)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (143577714..144216567)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (143886988..144525921)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit a-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16599 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16600 Neighboring gene uncharacterized LOC107985949 Neighboring gene MT-ATP6 pseudogene 5 Neighboring gene MT-CO2 pseudogene 5 Neighboring gene VISTA enhancer hs675 Neighboring gene NANOG hESC enhancer GRCh37_chr2:144238365-144238878 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:144239108-144239868 Neighboring gene uncharacterized LOC101928361 Neighboring gene ARHGAP15 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:144419424-144419959 Neighboring gene NANOG hESC enhancer GRCh37_chr2:144486483-144487103 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:144537063-144537656 Neighboring gene MPRA-validated peak3890 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:144649008-144649513 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:144649514-144650018 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:144664226-144664784 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:144694058-144694741 Neighboring gene uncharacterized LOC101928386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11990 Neighboring gene glycosyltransferase like domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16601 Neighboring gene MPRA-validated peak3893 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:145025446-145026228 Neighboring gene Sharpr-MPRA regulatory region 4867 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:145045189-145045690 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:145048337-145048837 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:145090135-145090712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:145114539-145115052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16603 Neighboring gene skeletal muscle cis-regulatory module overlapping ZEB2 Neighboring gene Sharpr-MPRA regulatory region 3137 Neighboring gene VISTA enhancer hs407 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:145236544-145237256 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:145267859-145268774 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:145274915-145275416 Neighboring gene zinc finger E-box binding homeobox 2 Neighboring gene ZEB2 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling. Radu M, et al. J Biol Chem, 2013 Jul 19. PMID 23760270, Free PMC Article
    2. ARHGAP15 in Human Breast Carcinoma: A Potent Tumor Suppressor Regulated by Androgens. Takagi K, et al. Int J Mol Sci, 2018 Mar 10. PMID 29534468, Free PMC Article
    3. Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN/AKT/FOXO1 axis. Pan S, et al. Cell Death Dis, 2018 Jun 4. PMID 29867200, Free PMC Article
    4. COLQ and ARHGAP15 are Associated with Diverticular Disease and are Expressed in the Colon. Kline BP, et al. J Surg Res, 2021 Nov. PMID 34225052
    5. ARHGAP15 regulates lung cancer cell proliferation and metastasis via the STAT3 pathway. Liu ZD, et al. Eur Rev Med Pharmacol Sci, 2019 Jul. PMID 31298335

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. COLQ and ARHGAP15 are Associated with Diverticular Disease and are Expressed in the Colon.
      Title: COLQ and ARHGAP15 are Associated with Diverticular Disease and are Expressed in the Colon.
    2. ARHGAP15 regulates lung cancer cell proliferation and metastasis via the STAT3 pathway.
      Title: ARHGAP15 regulates lung cancer cell proliferation and metastasis via the STAT3 pathway.
    3. ARHGAP15 might serve as a tumor suppressor during colorectal cancer progression.
      Title: Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN/AKT/FOXO1 axis.
    4. ARHGAP15 rs4662344-T ssociation with diverticular disease in Iceland and Denmark population.
      Title: Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis.
    5. ARHGAP15 immunoreactivity correlated with decreased risk of recurrence and improved prognosis in breast carcinoma. ARHGA15 overexpression suppressed cell proliferation and migration of MCF-7 cells.
      Title: ARHGAP15 in Human Breast Carcinoma: A Potent Tumor Suppressor Regulated by Androgens.
    6. FOXP3 can regulate the expression of ARHGAP15 and affects migration of glioma cells through the Rac1 signaling pathway
      Title: Forkhead box P3 regulates ARHGAP15 expression and affects migration of glioma cells through the Rac1 signaling pathway.
    7. ArhGAP15 plays a dual negative role in regulating small GTPase signaling, by acting at the level of the GTPase itself, as well interacting with its effector, Pak kinase.
      Title: ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling.
    8. ARHGAP15 is associated with acute lung injury in mice
      Title: Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.
    10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
    EBI GWAS Catalog
    Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
    EBI GWAS Catalog
    Genome-wide association study of selenium concentrations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 15
    Names
    rho-type GTPase-activating protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018460.4 → NP_060930.3  rho GTPase-activating protein 15

      See identical proteins and their annotated locations for NP_060930.3

      Status: VALIDATED

      Source sequence(s)
      BC038976, BP299206
      Consensus CDS
      CCDS2184.1
      UniProtKB/Swiss-Prot
      Q53QZ3, Q53R36, Q53RD7, Q53RT6, Q53SX9, Q584N9, Q6PJE6, Q86WP1, Q8IXX1, Q9NRL8, Q9NZ77, Q9NZ91
      Related
      ENSP00000295095.6, ENST00000295095.11
      Conserved Domains (3) summary
      cd04403
      Location:279 → 465
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:81 → 190
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:80 → 188
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      143129419..143768352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017004500.3 → XP_016859989.1  rho GTPase-activating protein 15 isoform X2

    2. XM_047445114.1 → XP_047301070.1  rho GTPase-activating protein 15 isoform X10

    3. XM_011511482.3 → XP_011509784.1  rho GTPase-activating protein 15 isoform X3

      Conserved Domains (3) summary
      cd13233
      Location:81 → 190
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:80 → 188
      PH; PH domain
      cl02570
      Location:279 → 414
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    4. XM_047445109.1 → XP_047301065.1  rho GTPase-activating protein 15 isoform X1

    5. XM_011511484.2 → XP_011509786.1  rho GTPase-activating protein 15 isoform X7

      Conserved Domains (3) summary
      cd13233
      Location:81 → 190
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:80 → 188
      PH; PH domain
      cl02570
      Location:279 → 334
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    6. XM_047445113.1 → XP_047301069.1  rho GTPase-activating protein 15 isoform X9

    7. XM_047445112.1 → XP_047301068.1  rho GTPase-activating protein 15 isoform X8

    8. XM_047445111.1 → XP_047301067.1  rho GTPase-activating protein 15 isoform X6

    9. XM_011511483.1 → XP_011509785.1  rho GTPase-activating protein 15 isoform X4

      Conserved Domains (2) summary
      cd04403
      Location:201 → 387
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cl17171
      Location:49 → 112
      PH-like; Pleckstrin homology-like domain

    10. XM_047445110.1 → XP_047301066.1  rho GTPase-activating protein 15 isoform X5

    11. XM_024453000.2 → XP_024308768.1  rho GTPase-activating protein 15 isoform X11

      Conserved Domains (1) summary
      cd04403
      Location:45 → 231
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

    RNA

    1. XR_007078554.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      143577714..144216567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343008.1 → XP_054198983.1  rho GTPase-activating protein 15 isoform X2

    2. XM_054343015.1 → XP_054198990.1  rho GTPase-activating protein 15 isoform X10

    3. XM_054343009.1 → XP_054198984.1  rho GTPase-activating protein 15 isoform X3

    4. XM_054343007.1 → XP_054198982.1  rho GTPase-activating protein 15 isoform X1

    5. XM_054343014.1 → XP_054198989.1  rho GTPase-activating protein 15 isoform X9

    6. XM_054343013.1 → XP_054198988.1  rho GTPase-activating protein 15 isoform X8

    7. XM_054343012.1 → XP_054198987.1  rho GTPase-activating protein 15 isoform X6

    8. XM_054343010.1 → XP_054198985.1  rho GTPase-activating protein 15 isoform X4

    9. XM_054343011.1 → XP_054198986.1  rho GTPase-activating protein 15 isoform X5

    10. XM_054343016.1 → XP_054198991.1  rho GTPase-activating protein 15 isoform X11

    RNA

    1. XR_008486458.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53QZ3.2 GenPept UniProtKB/Swiss-Prot:Q53QZ3

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