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    FBXO25 F-box protein 25 [ Homo sapiens (human) ]

    Gene ID: 26260, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FBXO25provided by HGNC
    Official Full Name
    F-box protein 25provided by HGNC
    Primary source
    HGNC:HGNC:13596
    See related
    Ensembl:ENSG00000147364 MIM:609098; AllianceGenome:HGNC:13596
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBX25
    Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 13.0), thyroid (RPKM 5.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FBXO25 in Genome Data Viewer
    Location:
    8p23.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (406958..477967)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (204109..275198)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (356958..427967)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377773 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:299727-300260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:328556-329056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18878 Neighboring gene family with sequence similarity 87 member A Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:429047-429548 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:429549-430048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:436623-437436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:437437-438248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:452724-453298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:482877-483378 Neighboring gene testis development related protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:487215-487724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:486704-487214 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:495813-496313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:527413-527914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:527915-528414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:563312-563864 Neighboring gene uncharacterized LOC124902055 Neighboring gene glutamate rich 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. FBXO25 promotes cell proliferation, invasion, and migration of NSCLC. Jiang GY, et al. Tumour Biol, 2016 Oct. PMID 27596142
    2. A novel Fbxo25 acts as an E3 ligase for destructing cardiac specific transcription factors. Jang JW, et al. Biochem Biophys Res Commun, 2011 Jul 1. PMID 21596019
    3. ELK-1 ubiquitination status and transcriptional activity are modulated independently of F-Box protein FBXO25. Quintero-Barceinas RS, et al. J Biol Chem, 2021 Jan-Jun. PMID 33428929, Free PMC Article
    4. HTLV-1 viral oncoprotein HBZ contributes to the enhancement of HAX-1 stability by impairing the ubiquitination pathway. Tanaka Y, et al. J Cell Physiol, 2021 Apr. PMID 32893878
    5. From man to fly - convergent evidence links FBXO25 to ADHD and comorbid psychiatric phenotypes. Harich B, et al. J Child Psychol Psychiatry, 2020 May. PMID 31849056, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. From man to fly - convergent evidence links FBXO25 to ADHD and comorbid psychiatric phenotypes.
      Title: From man to fly - convergent evidence links FBXO25 to ADHD and comorbid psychiatric phenotypes.
    2. ELK-1 ubiquitination status and transcriptional activity are modulated independently of F-Box protein FBXO25.
      Title: ELK-1 ubiquitination status and transcriptional activity are modulated independently of F-Box protein FBXO25.
    3. FBXO25 Promotes Cutaneous Squamous Cell Carcinoma Growth and Metastasis through Cyclin D1.
      Title: FBXO25 Promotes Cutaneous Squamous Cell Carcinoma Growth and Metastasis through Cyclin D1.
    4. LncRNA ODIR1 inhibits osteogenic differentiation of hUC-MSCs through the FBXO25/H2BK120ub/H3K4me3/OSX axis.
      Title: LncRNA ODIR1 inhibits osteogenic differentiation of hUC-MSCs through the FBXO25/H2BK120ub/H3K4me3/OSX axis.
    5. Taken together we show that FBXO25 functions as a negative regulator of MAPK signaling though the reduction of ERK1/2 activation.
      Title: FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation.
    6. High FBXO25 expression is associated with non-small-cell lung cancer.
      Title: FBXO25 promotes cell proliferation, invasion, and migration of NSCLC.
    7. FBXO25 functions as a haploinsufficient tumor suppressor in mantle cell lymphoma.
      Title: Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.
    8. FBXO25 mediates ELK-1 degradation through the ubiquitin proteasome system and thereby plays a role in regulating the activation of ELK-1 pathway in response to mitogens
      Title: The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein.
    9. Altogether, Fbxo25 acts as an ubiquitin E3 ligase to target cardiac transcription factors including Nkx2-5, Isl1, and Hand1, indicating that cardiac protein homeostasis through Fbxo25 has a pivotal impact on cardiac development.
      Title: A novel Fbxo25 acts as an E3 ligase for destructing cardiac specific transcription factors.
    10. Beta-actin, physically interacts through its N-terminus with FBXO25 and is enriched in the FBXO25 nuclear compartments.
      Title: Identification of FBXO25-interacting proteins using an integrated proteomics approach.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC20256, MGC51975

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ubiquitin ligase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box only protein 25
    Names
    F-box protein Fbx25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012173.4 → NP_036305.2  F-box only protein 25 isoform 3

      See identical proteins and their annotated locations for NP_036305.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two internal exons, as compared to variant 1. The encoded isoform (3) has an alternate N-terminus and lacks an internal segment in the 3' region, as compared to isoform 1.
      Source sequence(s)
      AA316216, AC083964, AF419858, AI223050, BC012143, BC050393
      Consensus CDS
      CCDS5954.1
      UniProtKB/Swiss-Prot
      Q8TCJ0
      Related
      ENSP00000341345.2, ENST00000352684.2

    2. NM_183420.2 → NP_904356.1  F-box only protein 25 isoform 2

      See identical proteins and their annotated locations for NP_904356.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, as compared to variant 1. The encoded isoform (2) is missing an internal segment, as compared to isoform 1.
      Source sequence(s)
      AA316216, AC083964, AF419858, AI223050, BC050393
      Consensus CDS
      CCDS5952.1
      UniProtKB/TrEMBL
      B4DYA3
      Related
      ENSP00000342077.4, ENST00000350302.8

    3. NM_183421.2 → NP_904357.1  F-box only protein 25 isoform 1

      See identical proteins and their annotated locations for NP_904357.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA316216, AC083964, AF419858, AI223050, BC050393
      Consensus CDS
      CCDS5953.1
      UniProtKB/Swiss-Prot
      Q6PJ83, Q7Z4V4, Q8TCJ0, Q9UKB8
      UniProtKB/TrEMBL
      B4DYA3
      Related
      ENSP00000372274.2, ENST00000382824.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      406958..477967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421684.1 → XP_047277640.1  F-box only protein 25 isoform X2

      UniProtKB/TrEMBL
      B4DYA3

    2. XM_017013314.2 → XP_016868803.1  F-box only protein 25 isoform X3

      UniProtKB/TrEMBL
      B4DYA3

    3. XM_024447125.2 → XP_024302893.1  F-box only protein 25 isoform X4

      UniProtKB/TrEMBL
      B4DYA3

    4. XM_017013313.3 → XP_016868802.1  F-box only protein 25 isoform X1

      UniProtKB/Swiss-Prot
      Q6PJ83, Q7Z4V4, Q8TCJ0, Q9UKB8
      UniProtKB/TrEMBL
      B4DYA3

    5. XM_011534748.4 → XP_011533050.1  F-box only protein 25 isoform X1

      See identical proteins and their annotated locations for XP_011533050.1

      UniProtKB/Swiss-Prot
      Q6PJ83, Q7Z4V4, Q8TCJ0, Q9UKB8
      UniProtKB/TrEMBL
      B4DYA3

    6. XM_024447123.2 → XP_024302891.1  F-box only protein 25 isoform X2

      UniProtKB/TrEMBL
      B4DYA3

    7. XM_047421683.1 → XP_047277639.1  F-box only protein 25 isoform X1

      UniProtKB/Swiss-Prot
      Q6PJ83, Q7Z4V4, Q8TCJ0, Q9UKB8
      UniProtKB/TrEMBL
      B4DYA3

    8. XM_024447124.2 → XP_024302892.1  F-box only protein 25 isoform X2

      UniProtKB/TrEMBL
      B4DYA3

    9. XM_047421685.1 → XP_047277641.1  F-box only protein 25 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      204109..275198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360277.1 → XP_054216252.1  F-box only protein 25 isoform X4

      UniProtKB/TrEMBL
      B4DYA3

    2. XM_054360275.1 → XP_054216250.1  F-box only protein 25 isoform X2

      UniProtKB/TrEMBL
      B4DYA3

    3. XM_054360274.1 → XP_054216249.1  F-box only protein 25 isoform X2

      UniProtKB/TrEMBL
      B4DYA3

    4. XM_054360276.1 → XP_054216251.1  F-box only protein 25 isoform X2

      UniProtKB/TrEMBL
      B4DYA3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TCJ0.3 GenPept UniProtKB/Swiss-Prot:Q8TCJ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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