ARHGEF11 Rho guanine nucleotide exchange factor 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ARHGEF11provided by HGNC
Official Full Name: Rho guanine nucleotide exchange factor 11provided by HGNC
Primary source: HGNC:HGNC:14580
See related: Ensembl:ENSG00000132694 MIM:605708; AllianceGenome:HGNC:14580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GTRAP48; PDZ-RHOGEF
Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 13.2), brain (RPKM 7.8) and 25 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q23.1

Exon count:: 47

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (156934840..157046903, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (156071681..156183721, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (156904632..157016695, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epigenetic alteration of Rho guanine nucleotide exchange Factor 11 (ARHGEF11) in cord blood samples in macrosomia exposed to intrauterine hyperglycemia.
Title: Epigenetic alteration of Rho guanine nucleotide exchange Factor 11 (ARHGEF11) in cord blood samples in macrosomia exposed to intrauterine hyperglycemia.
ARHGEF11 promotes proliferation and epithelial-mesenchymal transition of hepatocellular carcinoma through activation of beta-catenin pathway.
Title: ARHGEF11 promotes proliferation and epithelial-mesenchymal transition of hepatocellular carcinoma through activation of β-catenin pathway.
Galphas directly drives PDZ-RhoGEF signaling to Cdc42.
Title: Gα(s) directly drives PDZ-RhoGEF signaling to Cdc42.
results indicate that ARHGEF1 activity in human lymphocytes is involved in controlling actin cytoskeleton dynamics, restraining PI3K/AKT signaling, and confining B lymphocytes and myelocytes within their dedicated functional environment.
Title: Loss of ARHGEF1 causes a human primary antibody deficiency.
PDZ-RhoGEF role in the glioblastoma cell invasion and survival.PDZ-RhoGEF is an effector of TROY signaling.
Title: PDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival.
ARHGRF11 inhibited the insulin signaling pathway in placenta and may participate in fetal macrosomia in normal glucose tolerance pregnant women
Title: ARHGEF11 affecting the placental insulin signaling pathway in fetal macrosomia of normal glucose tolerance pregnant women.
SNPs associated with type 2 diabetes and obesity may also increase the risk of developing gestational diabetes mellitus (GDM) in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM.
Title: Genetic variants and clinical relevance associated with gestational diabetes mellitus in Chinese women: a case-control study.
PAK4 (but not PAK1) mediates invadopodia maturation during melanoma invasion likely via inhibition of PDZ-RhoGEF.
Title: PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells.
Data show that endothelin A receptor drives invadopodia function by direct interaction of beta-arrestin-1 (beta-arr1) with Rho guanine nucleotide exchange factor (GEF) 11 protein (PDZ-RhoGEF).
Title: Endothelin A receptor drives invadopodia function and cell motility through the β-arrestin/PDZ-RhoGEF pathway in ovarian carcinoma.
Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling.
Title: Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

SHGC-145882 (e-PCR)
- UniSTS:174852

SHGC-68674 (e-PCR)
- UniSTS:100665

AL034019 (e-PCR)
- UniSTS:93566

STS-AA039568 (e-PCR)
- UniSTS:29566

RH68042 (e-PCR)
- UniSTS:30103

RH64623 (e-PCR)
- UniSTS:76969

RH45970 (e-PCR)
- UniSTS:36281

SHGC-149619 (e-PCR)
- UniSTS:177118

SHGC-142538 (e-PCR)
- UniSTS:171517

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in actin cytoskeleton organization	NAS Non-traceable Author Statement more info	PubMed
involved_in establishment of cell polarity	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell growth	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
involved_in striated muscle contraction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

Go to the top of the page Help

Preferred Names: rho guanine nucleotide exchange factor 11

Names: Rho guanine exchange factor (GEF) 11; Rho guanine nucleotide exchange factor (GEF) 11; RhoA-specific guanine nucleotide exchange factor; RhoGEF glutamate transport modulator; glutamate transporter EAAT4-associated protein 48

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001377418.1 → NP_001364347.1 rho guanine nucleotide exchange factor 11 isoform 3

Status: REVIEWED

Source sequence(s)

AL157713, AL356104

UniProtKB/TrEMBL

A0AAQ5BII7

Related

ENSP00000520489.1, ENST00000715595.1

Conserved Domains (5) summary

cd08753
Location:326 → 470

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

PHA03307
Location:1209 → 1559

PHA03307; transcriptional regulator ICP4; Provisional

cd00160
Location:772 → 958

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00992
Location:42 → 116

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:976 → 1118

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
NM_001377419.1 → NP_001364348.1 rho guanine nucleotide exchange factor 11 isoform 4

Status: REVIEWED

Source sequence(s)

AL157713, AL356104

UniProtKB/TrEMBL

A0AAQ5BII7

Conserved Domains (5) summary

cd08753
Location:330 → 474

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

PHA03307
Location:1202 → 1552

PHA03307; transcriptional regulator ICP4; Provisional

cd00160
Location:765 → 951

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00992
Location:46 → 120

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:969 → 1111

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
NM_014784.4 → NP_055599.1 rho guanine nucleotide exchange factor 11 isoform 1

See identical proteins and their annotated locations for NP_055599.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the predominant isoform (1).

Source sequence(s)

AB002378, AL157713, BC057394

Consensus CDS

CCDS1162.1

UniProtKB/Swiss-Prot

D3DVD0, O15085, Q5VY40, Q6PFW2

UniProtKB/TrEMBL

A0A2X0SFB0

Related

ENSP00000354644.2, ENST00000361409.2

Conserved Domains (6) summary

cd08753
Location:290 → 434

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

COG0265
Location:61 → 139

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:46 → 120

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:939 → 1081

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

pfam00169
Location:999 → 1079

PH; PH domain

pfam00621
Location:738 → 922

RhoGEF; RhoGEF domain
NM_198236.3 → NP_937879.1 rho guanine nucleotide exchange factor 11 isoform 2

See identical proteins and their annotated locations for NP_937879.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is longer, compared to isoform 1.

Source sequence(s)

AL157713, BC057394

Consensus CDS

CCDS1163.1

UniProtKB/TrEMBL

A0AAQ5BII7

Related

ENSP00000357177.3, ENST00000368194.8

Conserved Domains (6) summary

cd08753
Location:330 → 474

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

COG0265
Location:61 → 139

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:46 → 120

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:979 → 1121

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

pfam00169
Location:1039 → 1119

PH; PH domain

pfam00621
Location:778 → 962

RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

156934840..157046903 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047435301.1 → XP_047291257.1 rho guanine nucleotide exchange factor 11 isoform X18

UniProtKB/TrEMBL

A0A2X0SFB0
XM_047435294.1 → XP_047291250.1 rho guanine nucleotide exchange factor 11 isoform X14

UniProtKB/TrEMBL

A0AAQ5BII7
XM_047435306.1 → XP_047291262.1 rho guanine nucleotide exchange factor 11 isoform X19

UniProtKB/TrEMBL

A0A2X0SFB0
XM_017002923.3 → XP_016858412.1 rho guanine nucleotide exchange factor 11 isoform X16

UniProtKB/TrEMBL

A0A2X0SFB0
XM_047435300.1 → XP_047291256.1 rho guanine nucleotide exchange factor 11 isoform X17

UniProtKB/TrEMBL

A0AAQ5BII7
XM_047435285.1 → XP_047291241.1 rho guanine nucleotide exchange factor 11 isoform X12

UniProtKB/TrEMBL

A0AAQ5BII7
XM_047435284.1 → XP_047291240.1 rho guanine nucleotide exchange factor 11 isoform X11

UniProtKB/TrEMBL

A0AAQ5BII7
XM_005245629.6 → XP_005245686.1 rho guanine nucleotide exchange factor 11 isoform X8

UniProtKB/TrEMBL

A0AAQ5BII7

Conserved Domains (6) summary

cd08753
Location:330 → 474

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

COG0265
Location:61 → 139

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:46 → 120

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:980 → 1122

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

pfam00169
Location:1040 → 1120

PH; PH domain

pfam00621
Location:779 → 963

RhoGEF; RhoGEF domain
XM_017002920.3 → XP_016858409.1 rho guanine nucleotide exchange factor 11 isoform X6

UniProtKB/TrEMBL

A0AAQ5BII7
XM_017002924.3 → XP_016858413.1 rho guanine nucleotide exchange factor 11 isoform X15

UniProtKB/TrEMBL

A0A2X0SFB0
XM_047435262.1 → XP_047291218.1 rho guanine nucleotide exchange factor 11 isoform X7

UniProtKB/TrEMBL

A0AAQ5BII7
XM_011510185.4 → XP_011508487.1 rho guanine nucleotide exchange factor 11 isoform X3

UniProtKB/TrEMBL

A0AAQ5BII7

Conserved Domains (6) summary

cd08753
Location:341 → 485

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

COG0265
Location:72 → 150

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:57 → 131

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:991 → 1133

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

pfam00169
Location:1051 → 1131

PH; PH domain

pfam00621
Location:790 → 974

RhoGEF; RhoGEF domain
XM_017002922.3 → XP_016858411.1 rho guanine nucleotide exchange factor 11 isoform X13

UniProtKB/TrEMBL

A0A2X0SFB0
XM_006711665.5 → XP_006711728.1 rho guanine nucleotide exchange factor 11 isoform X10

UniProtKB/TrEMBL

A0A2X0SFB0

Conserved Domains (6) summary

cd08753
Location:306 → 450

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

COG0265
Location:77 → 155

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:62 → 136

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:955 → 1097

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

pfam00169
Location:1015 → 1095

PH; PH domain

pfam00621
Location:754 → 938

RhoGEF; RhoGEF domain
XM_011510186.4 → XP_011508488.1 rho guanine nucleotide exchange factor 11 isoform X9

UniProtKB/TrEMBL

A0A2X0SFB0

Conserved Domains (6) summary

cd08753
Location:306 → 450

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

COG0265
Location:77 → 155

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:62 → 136

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:956 → 1098

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

pfam00169
Location:1016 → 1096

PH; PH domain

pfam00621
Location:755 → 939

RhoGEF; RhoGEF domain
XM_006711662.4 → XP_006711725.1 rho guanine nucleotide exchange factor 11 isoform X5

UniProtKB/TrEMBL

A0AAQ5BII7

Conserved Domains (6) summary

cd08753
Location:346 → 490

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

COG0265
Location:77 → 155

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:62 → 136

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:985 → 1127

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

pfam00169
Location:1045 → 1125

PH; PH domain

pfam00621
Location:784 → 968

RhoGEF; RhoGEF domain
XM_006711660.5 → XP_006711723.1 rho guanine nucleotide exchange factor 11 isoform X2

UniProtKB/TrEMBL

A0AAQ5BII7, A0AAQ5BIK5

Related

ENSP00000520488.1, ENST00000715594.1

Conserved Domains (6) summary

cd08753
Location:346 → 490

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

COG0265
Location:77 → 155

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:62 → 136

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:995 → 1137

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

pfam00169
Location:1055 → 1135

PH; PH domain

pfam00621
Location:794 → 978

RhoGEF; RhoGEF domain
XM_006711661.4 → XP_006711724.1 rho guanine nucleotide exchange factor 11 isoform X4

UniProtKB/TrEMBL

A0AAQ5BII7

Conserved Domains (6) summary

cd08753
Location:346 → 490

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

COG0265
Location:77 → 155

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:62 → 136

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:986 → 1128

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

pfam00169
Location:1046 → 1126

PH; PH domain

pfam00621
Location:785 → 969

RhoGEF; RhoGEF domain
XM_006711659.4 → XP_006711722.1 rho guanine nucleotide exchange factor 11 isoform X1

UniProtKB/TrEMBL

A0AAQ5BII7

Conserved Domains (6) summary

cd08753
Location:346 → 490

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

COG0265
Location:77 → 155

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:62 → 136

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:996 → 1138

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

pfam00169
Location:1056 → 1136

PH; PH domain

pfam00621
Location:795 → 979

RhoGEF; RhoGEF domain
XM_011510187.4 → XP_011508489.1 rho guanine nucleotide exchange factor 11 isoform X20

UniProtKB/TrEMBL

A0AAQ5BII7

Conserved Domains (5) summary

cd08753
Location:252 → 396

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

smart00228
Location:2 → 42

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd13391
Location:902 → 1044

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

pfam00169
Location:962 → 1042

PH; PH domain

pfam00621
Location:701 → 885

RhoGEF; RhoGEF domain
XM_005245633.5 → XP_005245690.1 rho guanine nucleotide exchange factor 11 isoform X21

UniProtKB/TrEMBL

B7Z7U2

Conserved Domains (4) summary

cd13391
Location:558 → 700

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

pfam00169
Location:618 → 698

PH; PH domain

pfam00621
Location:357 → 541

RhoGEF; RhoGEF domain

cl02565
Location:2 → 105

RGS; Regulator of G protein signaling (RGS) domain superfamily
XM_011510189.4 → XP_011508491.1 rho guanine nucleotide exchange factor 11 isoform X22

UniProtKB/TrEMBL

B7Z7U2

Conserved Domains (3) summary

cd13391
Location:362 → 504

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

pfam00169
Location:422 → 502

PH; PH domain

pfam00621
Location:161 → 345

RhoGEF; RhoGEF domain

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

156071681..156183721 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054339797.1 → XP_054195772.1 rho guanine nucleotide exchange factor 11 isoform X18

UniProtKB/TrEMBL

A0A2X0SFB0
XM_054339793.1 → XP_054195768.1 rho guanine nucleotide exchange factor 11 isoform X14

UniProtKB/TrEMBL

A0AAQ5BII7
XM_054339798.1 → XP_054195773.1 rho guanine nucleotide exchange factor 11 isoform X19

UniProtKB/TrEMBL

A0A2X0SFB0
XM_054339795.1 → XP_054195770.1 rho guanine nucleotide exchange factor 11 isoform X16

UniProtKB/TrEMBL

A0A2X0SFB0
XM_054339796.1 → XP_054195771.1 rho guanine nucleotide exchange factor 11 isoform X17

UniProtKB/TrEMBL

A0AAQ5BII7
XM_054339791.1 → XP_054195766.1 rho guanine nucleotide exchange factor 11 isoform X12

UniProtKB/TrEMBL

A0AAQ5BII7
XM_054339790.1 → XP_054195765.1 rho guanine nucleotide exchange factor 11 isoform X11

UniProtKB/TrEMBL

A0AAQ5BII7
XM_054339787.1 → XP_054195762.1 rho guanine nucleotide exchange factor 11 isoform X8

UniProtKB/TrEMBL

A0AAQ5BII7
XM_054339785.1 → XP_054195760.1 rho guanine nucleotide exchange factor 11 isoform X6

UniProtKB/TrEMBL

A0AAQ5BII7
XM_054339794.1 → XP_054195769.1 rho guanine nucleotide exchange factor 11 isoform X15

UniProtKB/TrEMBL

A0A2X0SFB0
XM_054339786.1 → XP_054195761.1 rho guanine nucleotide exchange factor 11 isoform X7

UniProtKB/TrEMBL

A0AAQ5BII7
XM_054339782.1 → XP_054195757.1 rho guanine nucleotide exchange factor 11 isoform X3

UniProtKB/TrEMBL

A0AAQ5BII7
XM_054339792.1 → XP_054195767.1 rho guanine nucleotide exchange factor 11 isoform X13

UniProtKB/TrEMBL

A0A2X0SFB0
XM_054339789.1 → XP_054195764.1 rho guanine nucleotide exchange factor 11 isoform X10

UniProtKB/TrEMBL

A0A2X0SFB0
XM_054339788.1 → XP_054195763.1 rho guanine nucleotide exchange factor 11 isoform X9

UniProtKB/TrEMBL

A0A2X0SFB0
XM_054339784.1 → XP_054195759.1 rho guanine nucleotide exchange factor 11 isoform X5

UniProtKB/TrEMBL

A0AAQ5BII7
XM_054339781.1 → XP_054195756.1 rho guanine nucleotide exchange factor 11 isoform X2

UniProtKB/TrEMBL

A0AAQ5BII7, A0AAQ5BIK5
XM_054339783.1 → XP_054195758.1 rho guanine nucleotide exchange factor 11 isoform X4

UniProtKB/TrEMBL

A0AAQ5BII7
XM_054339780.1 → XP_054195755.1 rho guanine nucleotide exchange factor 11 isoform X1

UniProtKB/TrEMBL

A0AAQ5BII7
XM_054339799.1 → XP_054195774.1 rho guanine nucleotide exchange factor 11 isoform X20

UniProtKB/TrEMBL

A0AAQ5BII7
XM_054339800.1 → XP_054195775.1 rho guanine nucleotide exchange factor 11 isoform X21

UniProtKB/TrEMBL

B7Z7U2
XM_054339801.1 → XP_054195776.1 rho guanine nucleotide exchange factor 11 isoform X22

UniProtKB/TrEMBL

B7Z7U2