TREM1 triggering receptor expressed on myeloid cells 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TREM1provided by HGNC
Official Full Name: triggering receptor expressed on myeloid cells 1provided by HGNC
Primary source: HGNC:HGNC:17760
See related: Ensembl:ENSG00000124731 MIM:605085; AllianceGenome:HGNC:17760
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD354; TREM-1
Summary: This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Expression: Biased expression in bone marrow (RPKM 10.0), appendix (RPKM 9.0) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (41267385..41286682, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (41096688..41115965, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (41235123..41254420, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pharmacological Inhibition or Silencing of TREM1 Restrains HCC Cell Metastasis by Inactivating TLR/PI3K/AKT Signaling.
Title: Pharmacological Inhibition or Silencing of TREM1 Restrains HCC Cell Metastasis by Inactivating TLR/PI3K/AKT Signaling.
TREM1: Activation, signaling, cancer and therapy.
Title: TREM1: Activation, signaling, cancer and therapy.
sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis.
Title: sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis.
Hypoxia-induced TREM1 promotes mesenchymal-like states of glioma stem cells via alternatively activating tumor-associated macrophages.
Title: Hypoxia-induced TREM1 promotes mesenchymal-like states of glioma stem cells via alternatively activating tumor-associated macrophages.
Molecular and immunological features of TREM1 and its emergence as a prognostic indicator in glioma.
Title: Molecular and immunological features of TREM1 and its emergence as a prognostic indicator in glioma.
The Interaction of HMGB1 with the Proinflammatory TREM-1 Receptor Generates Cytotoxic Lymphocytes Active against HLA-Negative Tumor Cells.
Title: The Interaction of HMGB1 with the Proinflammatory TREM-1 Receptor Generates Cytotoxic Lymphocytes Active against HLA-Negative Tumor Cells.
Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies.
Title: Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies.
Plasma IL-6, TREM1, uPAR, and IL6/IL8 biomarkers increment further witnessing the chronic inflammation in type 2 diabetes.
Title: Plasma IL-6, TREM1, uPAR, and IL6/IL8 biomarkers increment further witnessing the chronic inflammation in type 2 diabetes.
Is triggering receptor expressed on myeloid cell 1 (TREM-1) protein a new marker of serious infectious complications in colorectal surgery?: case-matched pilot study.
Title: Is triggering receptor expressed on myeloid cell 1 (TREM-1) protein a new marker of serious infectious complications in colorectal surgery?: case-matched pilot study.
Value of gingival crevicular fluid TREM-1, PGLYRP1, and IL-1beta levels during menopause.
Title: Value of gingival crevicular fluid TREM-1, PGLYRP1, and IL-1β levels during menopause.

Submit: New GeneRIF Correction See all GeneRIFs (240)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of triggering receptor expressed on myeloid cells 1 (TREM1) in peptide-treated PBMCs	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH121075 (e-PCR)
- UniSTS:132362

RH48773 (e-PCR)
- UniSTS:25705

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables receptor decoy activity	IDA Inferred from Direct Assay more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	TAS Traceable Author Statement more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cytokine production involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in humoral immune response	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil-mediated killing of gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: triggering receptor expressed on myeloid cells 1

Names: triggering receptor expressed on monocytes 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029525.2 RefSeqGene

Range

5038..18115

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001242589.3 → NP_001229518.1 triggering receptor expressed on myeloid cells 1 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs at the 3' end compared to variant 1. This results in a shorter isoform (2) with a distinct C-terminus, lacking the transmembrane domain, compared to isoform 1.

Source sequence(s)

AF287008, AK223264, AL391903, DC428714

Consensus CDS

CCDS59499.1

UniProtKB/TrEMBL

A8K7Z7

Related

ENSP00000465345.1, ENST00000591620.1

Conserved Domains (1) summary

cl11960
Location:33 → 118

Ig; Immunoglobulin domain
NM_001242590.3 → NP_001229519.1 triggering receptor expressed on myeloid cells 1 isoform 3 precursor

See identical proteins and their annotated locations for NP_001229519.1

Status: REVIEWED

Description

Transcript Variant: This variant (3; also known as TREM1-sv, PMID:11922939) is missing an internal coding exon compared to variant 1. This results in a frame-shift, and a shorter isoform (3) with a distinct C-terminus compared to isoform 1. This isoform, lacking the transmembrane domain, is likely secreted, and may function as a regulator of myeloid activation (PMID:11922939).

Source sequence(s)

AK301519, AL391903, CA417244, DA362458, DA938757

Consensus CDS

CCDS56427.1

UniProtKB/Swiss-Prot

Q9NP99

Related

ENSP00000334284.5, ENST00000334475.11

Conserved Domains (2) summary

smart00410
Location:27 → 133

IG_like; Immunoglobulin like

cl11960
Location:32 → 134

Ig; Immunoglobulin domain
NM_018643.5 → NP_061113.1 triggering receptor expressed on myeloid cells 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_061113.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AF287008, AL391903, CA417244, DA362458, DA938757

Consensus CDS

CCDS4854.1

UniProtKB/Swiss-Prot

B4DWG2, K7EJW1, Q53FL8, Q5T2C9, Q86YU1, Q9NP99

UniProtKB/TrEMBL

A8K7Z7, Q38L15

Related

ENSP00000244709.3, ENST00000244709.9

Conserved Domains (1) summary

cl11960
Location:33 → 118

Ig; Immunoglobulin domain

RNA

NR_136332.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF287008, AL391903, AW264786, BI910026, DA362458, DA938757

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

41267385..41286682 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011514696.3 → XP_011512998.1 triggering receptor expressed on myeloid cells 1 isoform X1

See identical proteins and their annotated locations for XP_011512998.1

UniProtKB/TrEMBL

A8K7Z7, K7EKM5

Related

ENSP00000465688.1, ENST00000589614.6

Conserved Domains (1) summary

cl11960
Location:33 → 118

Ig; Immunoglobulin domain
XM_011514697.1 → XP_011512999.1 triggering receptor expressed on myeloid cells 1 isoform X2

Conserved Domains (2) summary

smart00410
Location:27 → 133

IG_like; Immunoglobulin like

cl11960
Location:32 → 134

Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

41096688..41115965 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054355669.1 → XP_054211644.1 triggering receptor expressed on myeloid cells 1 isoform X1

UniProtKB/TrEMBL

K7EKM5
XM_054355670.1 → XP_054211645.1 triggering receptor expressed on myeloid cells 1 isoform X2