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    SRP9 signal recognition particle 9 [ Homo sapiens (human) ]

    Gene ID: 6726, updated on 10-Dec-2024

    Summary

    Official Symbol
    SRP9provided by HGNC
    Official Full Name
    signal recognition particle 9provided by HGNC
    Primary source
    HGNC:HGNC:11304
    See related
    Ensembl:ENSG00000143742 MIM:600707; AllianceGenome:HGNC:11304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALURBP
    Summary
    Predicted to enable RNA binding activity and signal recognition particle binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in cytosol. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal (RPKM 131.7), brain (RPKM 102.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SRP9 in Genome Data Viewer
    Location:
    1q42.12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (225777826..225790464)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (224965843..224978462)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (225965528..225978166)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985352 Neighboring gene RNA, U6 small nuclear 1304, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:225938191-225938690 Neighboring gene uncharacterized LOC124904527 Neighboring gene VISTA enhancer hs2374 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:225956009-225956180 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5770 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:225964521-225965281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:225969251-225969750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1859 Neighboring gene left-right determination factor 3, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226004679-226005506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226005507-226006333 Neighboring gene epoxide hydrolase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226012583-226013259 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226015269-226016122 Neighboring gene transmembrane protein 63A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Downregulation of guanine nucleotide-releasing protein, CD151/PETA-3, neuronatin, neuroendocrine differentiation factor, mitochondria 16s rRNA, and signal recognition particle is observed in HIV-1 infected and HIV-1 gp120-treated astrocytes PubMed
    Rev rev HIV-1 Rev interacting protein, signal recognition particle 9kDa (SRP9), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SRP9 is increased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    signal recognition particle 9 kDa protein
    Names
    signal recognition particle 9kD
    signal recognition particle 9kDa
    NP_001123912.1
    NP_003124.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130440.2NP_001123912.1  signal recognition particle 9 kDa protein isoform 1

      See identical proteins and their annotated locations for NP_001123912.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      BC021995, DA983529, EF488978
      Consensus CDS
      CCDS44323.1
      Related
      ENSP00000355804.4, ENST00000366839.8
      Conserved Domains (1) summary
      pfam05486
      Location:451
      SRP9-21; Signal recognition particle 9 kDa protein (SRP9)
    2. NM_003133.6NP_003124.1  signal recognition particle 9 kDa protein isoform 2

      See identical proteins and their annotated locations for NP_003124.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon, as compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      BC008443, BC021995, DA983529
      Consensus CDS
      CCDS1546.1
      UniProtKB/Swiss-Prot
      A8K0N0, P49458, Q6NVX0, Q8WTW0
      Related
      ENSP00000305230.7, ENST00000304786.12
      Conserved Domains (1) summary
      pfam05486
      Location:473
      SRP9-21; Signal recognition particle 9 kDa protein (SRP9)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      225777826..225790464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      224965843..224978462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)