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    calr3a calreticulin 3a [ Danio rerio (zebrafish) ]

    Gene ID: 30248, updated on 4-Jan-2025

    Summary

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    Official Symbol
    calr3aprovided by ZNC
    Official Full Name
    calreticulin 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000208-17
    See related
    Ensembl:ENSDARG00000103979 AllianceGenome:ZFIN:ZDB-GENE-000208-17
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    calr; zgc:85636
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in ERAD pathway and protein folding. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including axis; cardiovascular system; hatching gland; periderm; and polster. Orthologous to human CALR3 (calreticulin 3). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See calr3a in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (4762478..4769054, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (4378103..4384679, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene transfer RNA aspartic acid (anticodon GUC) Neighboring gene RAD23 homolog A, nucleotide excision repair protein b Neighboring gene LOC100332737 Neighboring gene novel protein with Immunoglobulin V-set domains

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Floor plate develops upon depletion of tiggy-winkle and sonic hedgehog. Etheridge LA, et al. Genesis, 2001 Jul. PMID 11477699
    2. Expression of CALR mutants causes mpl-dependent thrombocytosis in zebrafish. Lim KH, et al. Blood Cancer J, 2016 Oct 7. PMID 27716741, Free PMC Article
    3. Activation of the Nkx2.5-Calr-p53 signaling pathway by hyperglycemia induces cardiac remodeling and dysfunction in adult zebrafish. Sun Y, et al. Dis Model Mech, 2017 Oct 1. PMID 28801532, Free PMC Article
    4. Calnexin is required for zebrafish posterior lateral line development. Hung IC, et al. Int J Dev Biol, 2013. PMID 23873374
    5. Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish. Thakur PC, et al. Hepatology, 2011 Aug. PMID 21488074, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calreticulin 3a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131047.2 → NP_571122.2  calreticulin 3a precursor

      Status: VALIDATED

      Source sequence(s)
      CR751224, CU570881
      UniProtKB/TrEMBL
      A0A8M1PB70, Q6PE26
      Related
      ENSDARP00000130666.1, ENSDART00000165235.2
      Conserved Domains (1) summary
      pfam00262
      Location:23 → 332
      Calreticulin; Calreticulin family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      4762478..4769054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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