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    chek2.L checkpoint kinase 2 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 398179, updated on 4-Jan-2025

    Summary

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    Official Symbol
    chek2.L
    Official Full Name
    checkpoint kinase 2 L homeolog
    Primary source
    Xenbase:XB-GENE-5765457
    Locus tag
    XELAEV_18007530mg
    See related
    AllianceGenome:Xenbase:XB-GENE-5765457
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    cds1; chk2; lfs2; chek2; rad53; hucds1; pp1425
    Summary
    Predicted to enable ATP binding activity and protein kinase activity. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Orthologous to human CHEK2 (checkpoint kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See chek2.L in Genome Data Viewer
    Location:
    chromosome: 1L
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (162940720..162963661, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (149853620..149876481, complement)

    Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 28 L homeolog Neighboring gene solute carrier family 2 member 7 L homeolog Neighboring gene leucine rich repeat containing 74A L homeolog Neighboring gene HscB mitochondrial iron-sulfur cluster co-chaperone L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chk2/Cds1 protein kinase blocks apoptosis during early development of Xenopus laevis. Wroble BN, et al. Dev Dyn, 2005 Aug. PMID 15937936
    2. Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends. Guo Z, et al. Mol Biol Cell, 2000 May. PMID 10793133, Free PMC Article
    3. Xenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA ends. McSherry TD, et al. Mol Cell Biol, 2004 Nov. PMID 15509799, Free PMC Article
    4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chk2/Cds kinase operates at a switch between cell cycle arrest or apoptosis in response to genomic assaults.
      Title: Chk2/Cds1 protein kinase blocks apoptosis during early development of Xenopus laevis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    checkpoint kinase 2 L homeolog
    Names
    CHK2 checkpoint homolog
    protein kinase Cds1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001088547.1 → NP_001082016.1  checkpoint kinase 2 L homeolog

      See identical proteins and their annotated locations for NP_001082016.1

      Status: PROVISIONAL

      Source sequence(s)
      AF174295
      UniProtKB/TrEMBL
      Q98TW0, Q9I8V3
      Conserved Domains (3) summary
      smart00220
      Location:192 → 458
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00060
      Location:84 → 174
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:185 → 458
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      162940720..162963661 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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