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    SEPTIN2 septin 2 [ Homo sapiens (human) ]

    Gene ID: 4735, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SEPTIN2provided by HGNC
    Official Full Name
    septin 2provided by HGNC
    Primary source
    HGNC:HGNC:7729
    See related
    Ensembl:ENSG00000168385 MIM:601506; AllianceGenome:HGNC:7729
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIFF6; NEDD5; SEPT2; NEDD-5; Pnutl3; hNedd5; Septin-2
    Summary
    Enables identical protein binding activity. Predicted to be involved in several processes, including cilium assembly; regulation of exocytosis; and smoothened signaling pathway. Predicted to act upstream of or within regulation of L-glutamate import across plasma membrane and regulation of protein localization. Located in several cellular components, including cytoskeleton; photoreceptor connecting cilium; and sperm annulus. Part of septin complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in fat (RPKM 77.8), thyroid (RPKM 76.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SEPTIN2 in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (241315355..241354027)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (241814341..241852889)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242254770..242293442)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene anoctamin 7 Neighboring gene uncharacterized LOC105376810 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242175313-242175524 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242189957-242190163 Neighboring gene high density lipoprotein binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12534 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:242220649-242221149 Neighboring gene HDLBP antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242248819-242249320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17424 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242255088-242255812 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242255813-242256537 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12537 Neighboring gene uncharacterized LOC105373973 Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 2 Neighboring gene Sharpr-MPRA regulatory region 5168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242386413-242387062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242407765-242408327 Neighboring gene microRNA 3133

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6. Mori T, et al. Cytogenet Cell Genet, 1996. PMID 8697812
    2. Coupling function of cyclin-dependent kinase 2 and Septin2 in the promotion of hepatocellular carcinoma. Xu C, et al. Cancer Sci, 2019 Feb. PMID 30444001, Free PMC Article
    3. Functional Redundancy of Septin Homologs in Dendritic Branching. Kaplan C, et al. Front Cell Dev Biol, 2017. PMID 28265560, Free PMC Article
    4. Septin Mutations in Human Cancers. Angelis D, et al. Front Cell Dev Biol, 2016. PMID 27882315, Free PMC Article
    5. Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial Monolayers. Kim J, et al. Arterioscler Thromb Vasc Biol, 2021 Jan. PMID 33147991, Free PMC Article

    See all (190) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circ_0057558 accelerates the development of prostate cancer through miR-1238-3p/SEPT2 axis.
      Title: Circ_0057558 accelerates the development of prostate cancer through miR-1238-3p/SEPT2 axis.
    2. ARHGAP4-SEPT2-SEPT9 complex enables both up- and down-modulation of integrin-mediated focal adhesions, cell migration, and invasion.
      Title: ARHGAP4-SEPT2-SEPT9 complex enables both up- and down-modulation of integrin-mediated focal adhesions, cell migration, and invasion.
    3. An atomic model for the human septin hexamer by cryo-EM.
      Title: An atomic model for the human septin hexamer by cryo-EM.
    4. The LncRNA FGD5-AS1/miR-497-5p axis regulates septin 2 (SEPT2) to accelerate cancer progression and increase cisplatin-resistance in laryngeal squamous cell carcinoma.
      Title: The LncRNA FGD5-AS1/miR-497-5p axis regulates septin 2 (SEPT2) to accelerate cancer progression and increase cisplatin-resistance in laryngeal squamous cell carcinoma.
    5. Orientational Ambiguity in Septin Coiled Coils and its Structural Basis.
      Title: Orientational Ambiguity in Septin Coiled Coils and its Structural Basis.
    6. MicroRNA7445p is downregulated in colorectal cancer and targets SEPT2 to suppress the malignant phenotype.
      Title: MicroRNA‑744‑5p is downregulated in colorectal cancer and targets SEPT2 to suppress the malignant phenotype.
    7. Molecular Recognition at Septin Interfaces: The Switches Hold the Key.
      Title: Molecular Recognition at Septin Interfaces: The Switches Hold the Key.
    8. Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial Monolayers.
      Title: Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial Monolayers.
    9. The long non-coding RNA LINC00473 contributes to cell proliferation via JAK-STAT3 signaling pathway by regulating miR-195-5p/SEPT2 axis in prostate cancer.
      Title: The long non-coding RNA LINC00473 contributes to cell proliferation via JAK-STAT3 signaling pathway by regulating miR-195-5p/SEPT2 axis in prostate cancer.
    10. Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis.
      Title: Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0158

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding HDA PubMed 
    enables enzyme regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of L-glutamate import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in photoreceptor connecting cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm annulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    septin-2
    Names
    epididymis secretory sperm binding protein
    neural precursor cell expressed, developmentally down-regulated 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008491.3 → NP_001008491.1  septin-2 isoform a

      See identical proteins and their annotated locations for NP_001008491.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
      Source sequence(s)
      AA482233, BC014455, BX648000, D63878
      Consensus CDS
      CCDS2548.1
      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
      Related
      ENSP00000353157.3, ENST00000360051.7
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 306
      Septin

    2. NM_001008492.3 → NP_001008492.1  septin-2 isoform a

      See identical proteins and their annotated locations for NP_001008492.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
      Source sequence(s)
      AA482233, BX648000, D63878, DB091579
      Consensus CDS
      CCDS2548.1
      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
      Related
      ENSP00000385172.2, ENST00000402092.6
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 306
      Septin

    3. NM_001282972.2 → NP_001269901.1  septin-2 isoform b

      See identical proteins and their annotated locations for NP_001269901.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a longer and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AA482233, AK294563, BX648000, D63878, DB091579
      Consensus CDS
      CCDS74682.1
      UniProtKB/Swiss-Prot
      Q15019
      Related
      ENSP00000479861.1, ENST00000616972.4
      Conserved Domains (2) summary
      COG5019
      Location:50 → 369
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:69 → 341
      Septin; Septin

    4. NM_001282973.2 → NP_001269902.1  septin-2 isoform c

      See identical proteins and their annotated locations for NP_001269902.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and contains an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (c) is longer than isoform a. Variants 6 and 15 encode the same isoform (c).
      Source sequence(s)
      AA482233, BC014455, BC033559, BX648000
      Consensus CDS
      CCDS63195.1
      UniProtKB/TrEMBL
      A0A384N6H6
      Related
      ENSP00000385109.1, ENST00000401990.5
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 316
      Septin; Septin

    5. NM_001321029.2 → NP_001307958.1  septin-2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) has a longer and distinct N-terminus compared to isoform a.
      Source sequence(s)
      BC033559, BX648000, D63878, R38654
      UniProtKB/Swiss-Prot
      Q15019
      Conserved Domains (2) summary
      COG5019
      Location:45 → 362
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:64 → 336
      Septin; Septin

    6. NM_001321030.3 → NP_001307959.1  septin-2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
      Source sequence(s)
      BX648000, D63878, DA544741, DB224668, R38654
      Consensus CDS
      CCDS2548.1
      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 306
      Septin

    7. NM_001321031.2 → NP_001307960.1  septin-2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
      Source sequence(s)
      BX648000, D63878, DA444624, R38654
      Consensus CDS
      CCDS2548.1
      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 306
      Septin

    8. NM_001321032.2 → NP_001307961.1  septin-2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
      Source sequence(s)
      BX648000, CN282754, D63878, DB091579, R38654
      Consensus CDS
      CCDS2548.1
      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 306
      Septin

    9. NM_001321033.3 → NP_001307962.1  septin-2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
      Source sequence(s)
      AC104841, BX648000, D63878, DB224668, HY043466, R38654
      Consensus CDS
      CCDS2548.1
      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 306
      Septin

    10. NM_001321034.2 → NP_001307963.1  septin-2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
      Source sequence(s)
      BX648000, D63878, DB091579, DB277926, R38654
      Consensus CDS
      CCDS2548.1
      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 306
      Septin

    11. NM_001321035.2 → NP_001307964.1  septin-2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
      Source sequence(s)
      BX648000, CN282712, D63878, DB091579, R38654
      Consensus CDS
      CCDS2548.1
      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 306
      Septin

    12. NM_001349287.2 → NP_001336216.1  septin-2 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR and the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (e) has a longer and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC005104, AC104841, R38654
      Conserved Domains (1) summary
      pfam00735
      Location:90 → 361
      Septin

    13. NM_001349288.2 → NP_001336217.1  septin-2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15) differs in the 5' UTR and contains an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (c) is longer than isoform a. Variants 6 and 15 encode the same isoform (c).
      Source sequence(s)
      AC005104, AC104841, R38654
      Consensus CDS
      CCDS63195.1
      UniProtKB/TrEMBL
      A0A384N6H6
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 316
      Septin; Septin

    14. NM_001349289.2 → NP_001336218.1  septin-2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
      Source sequence(s)
      AC005104, AC104841, R38654
      Consensus CDS
      CCDS2548.1
      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 306
      Septin

    15. NM_001349290.2 → NP_001336219.1  septin-2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
      Source sequence(s)
      AC005104, AC104841, R38654
      Consensus CDS
      CCDS2548.1
      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 306
      Septin

    16. NM_001349291.2 → NP_001336220.1  septin-2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
      Source sequence(s)
      AC005104, AC104841, R38654
      Consensus CDS
      CCDS2548.1
      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 306
      Septin

    17. NM_001349302.2 → NP_001336231.1  septin-2 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19) differs in the 5' UTR and the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (f) has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AC005104, AC104841, R38654
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 303
      Septin

    18. NM_001349304.2 → NP_001336233.1  septin-2 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (g) has a shorter N-terminus compared to isoform a. Variants 20-22 encode the same isoform (g).
      Source sequence(s)
      AC005104, AC104841, R38654
      Consensus CDS
      CCDS86930.1
      UniProtKB/TrEMBL
      B5MCX3
      Related
      ENSP00000384525.1, ENST00000407971.5
      Conserved Domains (1) summary
      pfam00735
      Location:1 → 266
      Septin

    19. NM_001349305.2 → NP_001336234.1  septin-2 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (g) has a shorter N-terminus compared to isoform a. Variants 20-22 encode the same isoform (g).
      Source sequence(s)
      AC005104, AC104841, R38654
      Consensus CDS
      CCDS86930.1
      UniProtKB/TrEMBL
      B5MCX3
      Conserved Domains (1) summary
      pfam00735
      Location:1 → 266
      Septin

    20. NM_001349306.2 → NP_001336235.1  septin-2 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (22) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (g) has a shorter N-terminus compared to isoform a. Variants 20-22 encode the same isoform (g).
      Source sequence(s)
      AC005104, AC104841, R38654
      Consensus CDS
      CCDS86930.1
      UniProtKB/TrEMBL
      B5MCX3
      Conserved Domains (1) summary
      pfam00735
      Location:1 → 266
      Septin

    21. NM_001349307.2 → NP_001336236.1  septin-2 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (23) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
      Source sequence(s)
      AC005104, AC104841, R38654
      UniProtKB/TrEMBL
      H7C2Y0
      Conserved Domains (1) summary
      cl40481
      Location:1 → 139
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    22. NM_001349308.2 → NP_001336237.1  septin-2 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (24) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
      Source sequence(s)
      AC005104, AC104841, R38654
      UniProtKB/TrEMBL
      H7C2Y0
      Conserved Domains (1) summary
      cl40481
      Location:1 → 139
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    23. NM_001349309.2 → NP_001336238.1  septin-2 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (25) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
      Source sequence(s)
      AC005104, AC104841, R38654
      UniProtKB/TrEMBL
      H7C2Y0
      Conserved Domains (1) summary
      cl40481
      Location:1 → 139
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    24. NM_001349310.2 → NP_001336239.1  septin-2 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (26) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
      Source sequence(s)
      AC005104, AC104841, R38654
      UniProtKB/TrEMBL
      H7C2Y0
      Conserved Domains (1) summary
      cl40481
      Location:1 → 139
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    25. NM_001349311.2 → NP_001336240.1  septin-2 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (27) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
      Source sequence(s)
      AC005104, AC104841, R38654
      UniProtKB/TrEMBL
      H7C2Y0
      Conserved Domains (1) summary
      cl40481
      Location:1 → 139
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    26. NM_001349312.2 → NP_001336241.1  septin-2 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (28) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
      Source sequence(s)
      AC005104, AC104841, R38654
      UniProtKB/TrEMBL
      H7C2Y0
      Conserved Domains (1) summary
      cl40481
      Location:1 → 139
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    27. NM_001349313.2 → NP_001336242.1  septin-2 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (29) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
      Source sequence(s)
      AC005104, AC104841, R38654
      UniProtKB/TrEMBL
      H7C2Y0
      Conserved Domains (1) summary
      cl40481
      Location:1 → 139
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    28. NM_001349314.2 → NP_001336243.1  septin-2 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (30) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
      Source sequence(s)
      AC005104, AC104841, R38654
      UniProtKB/TrEMBL
      H7C2Y0
      Conserved Domains (1) summary
      cl40481
      Location:1 → 139
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    29. NM_001349315.2 → NP_001336244.1  septin-2 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (31) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform a. Variants 23-31 encode the same isoform (h).
      Source sequence(s)
      AC005104, AC104841, R38654
      UniProtKB/TrEMBL
      H7C2Y0
      Conserved Domains (1) summary
      cl40481
      Location:1 → 139
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    30. NM_004404.5 → NP_004395.1  septin-2 isoform a

      See identical proteins and their annotated locations for NP_004395.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
      Source sequence(s)
      AA482233, AF038404, BX648000, DB091579
      Consensus CDS
      CCDS2548.1
      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
      Related
      ENSP00000375832.2, ENST00000391971.7
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 306
      Septin

    31. NM_006155.3 → NP_006146.1  septin-2 isoform a

      See identical proteins and their annotated locations for NP_006146.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4, 8-13, and 16-18 encode the same isoform (a).
      Source sequence(s)
      AA482233, BX648000, D63878, DB035463, DB095611
      Consensus CDS
      CCDS2548.1
      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
      Related
      ENSP00000375834.2, ENST00000391973.6
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 306
      Septin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      241315355..241354027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024452921.2 → XP_024308689.1  septin-2 isoform X1

      Conserved Domains (1) summary
      pfam00735
      Location:102 → 373
      Septin; Septin

    2. XM_024452920.2 → XP_024308688.1  septin-2 isoform X1

      Conserved Domains (1) summary
      pfam00735
      Location:102 → 373
      Septin; Septin

    3. XM_047444494.1 → XP_047300450.1  septin-2 isoform X2

    4. XM_047444495.1 → XP_047300451.1  septin-2 isoform X3

    5. XM_047444499.1 → XP_047300455.1  septin-2 isoform X4

      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0

    6. XM_047444492.1 → XP_047300448.1  septin-2 isoform X1

    7. XM_024452922.2 → XP_024308690.1  septin-2 isoform X2

      Conserved Domains (1) summary
      pfam00735
      Location:97 → 368
      Septin

    8. XM_047444496.1 → XP_047300452.1  septin-2 isoform X3

    9. XM_047444498.1 → XP_047300454.1  septin-2 isoform X4

      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0

    10. XM_024452925.2 → XP_024308693.1  septin-2 isoform X4

      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0
      Conserved Domains (1) summary
      pfam00735
      Location:35 → 306
      Septin

    11. XM_047444493.1 → XP_047300449.1  septin-2 isoform X1

    12. XM_047444500.1 → XP_047300456.1  septin-2 isoform X5

    13. XM_047444497.1 → XP_047300453.1  septin-2 isoform X4

      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0

    14. XM_047444501.1 → XP_047300457.1  septin-2 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      241814341..241852889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342260.1 → XP_054198235.1  septin-2 isoform X1

    2. XM_054342259.1 → XP_054198234.1  septin-2 isoform X1

    3. XM_054342263.1 → XP_054198238.1  septin-2 isoform X2

    4. XM_054342265.1 → XP_054198240.1  septin-2 isoform X3

    5. XM_054342270.1 → XP_054198245.1  septin-2 isoform X4

      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0

    6. XM_054342261.1 → XP_054198236.1  septin-2 isoform X1

    7. XM_054342264.1 → XP_054198239.1  septin-2 isoform X2

    8. XM_054342266.1 → XP_054198241.1  septin-2 isoform X3

    9. XM_054342269.1 → XP_054198244.1  septin-2 isoform X4

      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0

    10. XM_054342267.1 → XP_054198242.1  septin-2 isoform X4

      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0

    11. XM_054342262.1 → XP_054198237.1  septin-2 isoform X1

    12. XM_054342271.1 → XP_054198246.1  septin-2 isoform X5

    13. XM_054342268.1 → XP_054198243.1  septin-2 isoform X4

      UniProtKB/Swiss-Prot
      B4DGE8, Q14132, Q15019, Q53QU3, Q8IUK9, Q96CB0

    14. XM_054342272.1 → XP_054198247.1  septin-2 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15019.1 GenPept UniProtKB/Swiss-Prot:Q15019

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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