U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    OPR1 12-oxophytodienoate reductase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844001, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    OPR1
    Official Full Name
    12-oxophytodienoate reductase 1
    Primary source
    TAIR:AT1G76680
    Locus tag
    AT1G76680
    See related
    Araport:AT1G76680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    12-oxophytodienoate reductase 1; 12-OXOPHYTODIENOATE REDUCTASE 1; ARABIDOPSIS 12-OXOPHYTODIENOATE REDUCTASE 1; ATOPR1; F28O16.5; F28O16_5
    Summary
    Encodes a member of an alpha/beta barrel fold family of FMN-containing oxidoreductases. One of the closely related 12-oxophytodienoic acid reductases. This enzyme is not expected to participate in jasmonic acid biosynthesis because during in vitro assays, it shows very little activity with the naturally occurring OPDA isomer. Shows activity towards 2,4,6-trinitrotoluene. Expressed predominately in root. Up-regulated by senescence and jasmonic acid. Induced by salicylic acid. Independent of NPR1 for their induction by salicylic acid. Predicted to be a cytosolic protein.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See OPR1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (28776626..28778837)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Nucleotide-sugar transporter family protein Neighboring gene miscRNA Neighboring gene 12-oxophytodienoate reductase 2 Neighboring gene DNAJ heat shock N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular cloning and characterization of 12-oxophytodienoate reductase, an enzyme of the octadecanoid signaling pathway from Arabidopsis thaliana. Structural and functional relationship to yeast old yellow enzyme. Schaller F, et al. J Biol Chem, 1997 Oct 31. PMID 9346960
    2. X-ray structure of Arabidopsis At1g77680, 12-oxophytodienoate reductase isoform 1. Fox BG, et al. Proteins, 2005 Oct 1. PMID 16080145
    3. X-ray structure of Arabidopsis At2g06050, 12-oxophytodienoate reductase isoform 3. Malone TE, et al. Proteins, 2005 Jan 1. PMID 15468319
    4. 12-Oxophytodienoate reductase 3 (OPR3) is the isoenzyme involved in jasmonate biosynthesis. Schaller F, et al. Planta, 2000 May. PMID 10872231
    5. Structure and regulation of OPR1 and OPR2, two closely related genes encoding 12-oxophytodienoic acid-10,11-reductases from Arabidopsis thaliana. Biesgen C, et al. Planta, 1999 Apr. PMID 10333582

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_106318.4
    NM_202428.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 12-oxophytodienoate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 12-oxophytodienoate reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    NOT involved_in jasmonic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence TAS
    Traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in oxylipin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within oxylipin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salicylic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    12-oxophytodienoate reductase 1
    NP_177794.1
    • 12-oxophytodienoate reductase 1 (OPR1); FUNCTIONS IN: 12-oxophytodienoate reductase activity; INVOLVED IN: in 7 processes; LOCATED IN: cellular_component unknown; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: seedling growth, developing seed stage; CONTAINS InterPro DOMAIN/s: NADH:flavin oxidoreductase/NADH oxidase, N-terminal (InterPro:IPR001155), Aldolase-type TIM barrel (InterPro:IPR013785); BEST Arabidopsis thaliana protein match is: 12-oxophytodienoate reductase 2 (TAIR:AT1G76690.1); Has 13181 Blast hits to 13160 proteins in 2055 species: Archae - 127; Bacteria - 9806; Metazoa - 29; Fungi - 862; Plants - 449; Viruses - 0; Other Eukaryotes - 1908 (source: NCBI BLink).
    NP_974157.1
    • 12-oxophytodienoate reductase 1 (OPR1); FUNCTIONS IN: 12-oxophytodienoate reductase activity; INVOLVED IN: in 7 processes; LOCATED IN: cellular_component unknown; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: seedling growth, developing seed stage; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), NADH:flavin oxidoreductase/NADH oxidase, N-terminal (InterPro:IPR001155); BEST Arabidopsis thaliana protein match is: 12-oxophytodienoate reductase 2 (TAIR:AT1G76690.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28776626..28778837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106318.4 → NP_177794.1  12-oxophytodienoate reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177794.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49259, Q8LAH7, Q9S806
      UniProtKB/TrEMBL
      A0A178WIM4, A0A5S9WUX6
      Conserved Domains (1) summary
      cd02933
      Location:11 → 350
      OYE_like_FMN; Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a ...

    2. NM_202428.2 → NP_974157.1  12-oxophytodienoate reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974157.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4I403
      Conserved Domains (1) summary
      cd02933
      Location:11 → 375
      OYE_like_FMN; Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LAH7.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.