Rbbp9 retinoblastoma binding protein 9, serine hydrolase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbbp9provided by MGI
Official Full Name: retinoblastoma binding protein 9, serine hydrolaseprovided by MGI
Primary source: MGI:MGI:1347074
See related: Ensembl:ENSMUSG00000027428 AllianceGenome:MGI:1347074
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bog
Summary: Predicted to enable hydrolase activity. Acts upstream of or within positive regulation of gene expression; response to nematode; and type II pneumocyte differentiation. Predicted to be located in nucleoplasm. Orthologous to human RBBP9 (RB binding protein 9, serine hydrolase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 13.0), CNS E11.5 (RPKM 11.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G1; 2 71.02 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (144384185..144392779, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (144542265..144550859, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lung fibroblasts produce IL-33 in response to stimulation with retinoblastoma-binding protein 9 via production of prostaglandin E2.
Title: Lung fibroblasts produce IL-33 in response to stimulation with retinoblastoma-binding protein 9 via production of prostaglandin E2.
first report of very pronounced and producible sex differences in expresion of RBBP9; RBBP9 expression inversely correlated with RB phosphorylation
Title: Novel retinoblastoma binding protein RBBP9 modulates sex-specific radiation responses in vivo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within interleukin-33 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within interleukin-33 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to nematode	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to nematode	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within type II pneumocyte differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: putative hydrolase RBBP9

Names: B5T-overexpressed gene protein; RBBP-9; retinoblastoma-binding protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.