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    Slc26a11 solute carrier family 26, member 11 [ Mus musculus (house mouse) ]

    Gene ID: 268512, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc26a11provided by MGI
    Official Full Name
    solute carrier family 26, member 11provided by MGI
    Primary source
    MGI:MGI:2444589
    See related
    Ensembl:ENSMUSG00000039908 AllianceGenome:MGI:2444589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KBAT; F630021I08Rik
    Summary
    Enables chloride channel activity and chloride:bicarbonate antiporter activity. Predicted to be involved in chloride transmembrane transport; oxalate transport; and sulfate transmembrane transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in forelimb bud. Orthologous to human SLC26A11 (solute carrier family 26 member 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 5.2), adrenal adult (RPKM 4.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc26a11 in Genome Data Viewer
    Location:
    11 E2; 11 83.36 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119246328..119271902)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119355509..119381076)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7111 Neighboring gene eukaryotic translation initiation factor 4A3 Neighboring gene caspase recruitment domain family, member 14 Neighboring gene N-sulfoglucosamine sulfohydrolase (sulfamidase) Neighboring gene STARR-seq mESC enhancer starr_31317 Neighboring gene microRNA 1932 Neighboring gene ring finger protein 213 Neighboring gene STARR-positive B cell enhancer ABC_E3043 Neighboring gene RIKEN cDNA A930037H05 gene Neighboring gene STARR-positive B cell enhancer ABC_E7112

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Slc26a11 is prominently expressed in the brain and functions as a chloride channel: expression in Purkinje cells and stimulation of V H⁺-ATPase. Rahmati N, et al. Pflugers Arch, 2013 Nov. PMID 23733100
    2. SLC26A11 (KBAT) in Purkinje Cells Is Critical for Inhibitory Transmission and Contributes to Locomotor Coordination. Rahmati N, et al. eNeuro, 2016 May-Jun. PMID 27390771, Free PMC Article
    3. Slc26a11, a chloride transporter, localizes with the vacuolar H(+)-ATPase of A-intercalated cells of the kidney. Xu J, et al. Kidney Int, 2011 Nov. PMID 21716257
    4. Placental, renal, and ileal sulfate transporter gene expression in mouse gestation. Dawson PA, et al. Biol Reprod, 2012 Aug. PMID 22674389
    5. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chloride:bicarbonate antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables secondary active sulfate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxalate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sodium-independent sulfate anion transporter
    Names
    anion exchanger Slc26a11
    kidney brain anion transporter
    novel sulfate transporter protein (Slc26a11)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178743.3 → NP_848858.2  sodium-independent sulfate anion transporter

      See identical proteins and their annotated locations for NP_848858.2

      Status: VALIDATED

      Source sequence(s)
      AF345196, AK052202, AL645911
      Consensus CDS
      CCDS25717.1
      UniProtKB/Swiss-Prot
      B2RQF3, Q80ZD3, Q8BTP1, Q8BWL3, Q8CHW8
      Related
      ENSMUSP00000050999.8, ENSMUST00000050880.8
      Conserved Domains (1) summary
      TIGR00815
      Location:18 → 542
      sulP; high affinity sulphate transporter 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      119246328..119271902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156722.1 → XP_036012615.1  sodium-independent sulfate anion transporter isoform X2

      UniProtKB/Swiss-Prot
      B2RQF3, Q80ZD3, Q8BTP1, Q8BWL3, Q8CHW8
      Conserved Domains (1) summary
      TIGR00815
      Location:18 → 542
      sulP; high affinity sulphate transporter 1

    2. XM_006533420.4 → XP_006533483.1  sodium-independent sulfate anion transporter isoform X4

      Conserved Domains (1) summary
      COG0659
      Location:101 → 419
      SUL1; Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism]

    3. XM_006533419.5 → XP_006533482.1  sodium-independent sulfate anion transporter isoform X3

      Conserved Domains (1) summary
      TIGR00815
      Location:18 → 451
      sulP; high affinity sulphate transporter 1

    4. XM_006533421.3 → XP_006533484.1  sodium-independent sulfate anion transporter isoform X5

      See identical proteins and their annotated locations for XP_006533484.1

      UniProtKB/Swiss-Prot
      Q80ZD3
      Conserved Domains (1) summary
      TIGR00815
      Location:96 → 370
      sulP; high affinity sulphate transporter 1

    5. XM_006533418.3 → XP_006533481.1  sodium-independent sulfate anion transporter isoform X1

      Conserved Domains (1) summary
      TIGR00815
      Location:35 → 559
      sulP; high affinity sulphate transporter 1

    RNA

    1. XR_004936974.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZD3.2 GenPept UniProtKB/Swiss-Prot:Q80ZD3

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