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    sppl2 signal peptide peptidase-like 2 [ Danio rerio (zebrafish) ]

    Gene ID: 325540, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sppl2provided by ZNC
    Official Full Name
    signal peptide peptidase-like 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4265
    See related
    Ensembl:ENSDARG00000030448 AllianceGenome:ZFIN:ZDB-GENE-030131-4265
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    SPPL2B; wu:fc16e01; wu:fc85d12; zgc:136525
    Summary
    Predicted to enable aspartic endopeptidase activity, intramembrane cleaving. Acts upstream of or within negative regulation of coagulation. Predicted to be located in endosome membrane. Predicted to be active in bounding membrane of organelle and endoplasmic reticulum membrane. Orthologous to human SPPL2B (signal peptide peptidase like 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sppl2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (37480654..37503009)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (37498197..37520552)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:dkey-127k13.1 Neighboring gene death-associated protein kinase 3 Neighboring gene rho/rac guanine nucleotide exchange factor (GEF) 18a Neighboring gene insulin receptor a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cellular functions of gamma-secretase-related proteins. Haffner C, et al. Neurodegener Dis, 2006. PMID 17047369
    2. Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. Krawitz P, et al. J Biol Chem, 2005 Nov 25. PMID 15998642
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER.
      Title: Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic endopeptidase activity, intramembrane cleaving IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane protein proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of coagulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi-associated vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lumenal side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signal peptide peptidase-like 2
    Names
    signal peptide peptidase-like protein 2
    NP_001038709.2
    XP_021334581.1
    XP_021334586.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045244.2 → NP_001038709.2  signal peptide peptidase-like 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      BX539340, EH550022, EH571140
      UniProtKB/TrEMBL
      A0A8M1NA84, F1QYI0
      Related
      ENSDARP00000032543.4, ENSDART00000029801.6
      Conserved Domains (2) summary
      cd02129
      Location:37 → 156
      PA_hSPPL_like; PA_hSPPL_like: Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the ...
      pfam04258
      Location:206 → 497
      Peptidase_A22B; Signal peptide peptidase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      37480654..37503009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478906.2 → XP_021334581.1  signal peptide peptidase-like 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QFX8
      Conserved Domains (2) summary
      cd02129
      Location:37 → 156
      PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
      pfam04258
      Location:206 → 471
      Peptidase_A22B; Signal peptide peptidase

    2. XM_021478911.2 → XP_021334586.1  signal peptide peptidase-like 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QFY1
      Conserved Domains (2) summary
      cd02129
      Location:37 → 156
      PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
      pfam04258
      Location:206 → 497
      Peptidase_A22B; Signal peptide peptidase

    RNA

    1. XR_224754.5 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001015067.1: Suppressed sequence

      Description
      NM_001015067.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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