Septin5 septin 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Septin5provided by RGD
Official Full Name: septin 5provided by RGD
Primary source: RGD:621763
See related: EnsemblRapid:ENSRNOG00000029912 AllianceGenome:RGD:621763
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GPIbB; Sept5; Pnutl1; CDCrel-1; CDCrel-1A; GPIb-beta
Summary: Enables several functions, including guanyl ribonucleotide binding activity; protein homodimerization activity; and syntaxin binding activity. Involved in positive regulation of exocytosis. Located in cleavage furrow; stress fiber; and synaptic vesicle. Part of septin complex. Orthologous to human SEPTIN5 (septin 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 507.0), Spleen (RPKM 33.0) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (95877946..95883738)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (82373601..82379393)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (86516377..86522169)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression levels of miR-185, SEPT5, LRRK2, and PARK2 genes were measured at a mRNA level in dopaminergic areas of rats' brains and SHSY-5Y cells using the SYBR Green Real-Time PCR Method.
Title: miR-185 and SEPT5 Genes May Contribute to Parkinson's Disease Pathophysiology.
Knockdown of SEPT5 or SEPT7 in developing hippocampal neurons impaired axon growth.
Title: Characterization of presynaptic septin complexes in mammalian hippocampal neurons.
The direct interaction between ARMS/Kidins220 and Sept5 suggests a possible role of ARMS/Kidins220 as a functional link between neurotrophin receptors and septins to mediate neurotrophin-induced intracellular signaling events.
Title: Ankyrin repeat-rich membrane spanning/Kidins220 protein interacts with mammalian Septin 5.
HSP70 and constitutively active HSF1 mediate protection against CDCrel-1-mediated toxicity
Title: HSP70 and constitutively active HSF1 mediate protection against CDCrel-1-mediated toxicity.
CDCrel-1 overexpression exerts dopamine-dependent neurotoxicity
Title: Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sept5 (e-PCR), detects polymorphism
- UniSTS:507214

RH133449 (e-PCR)
- UniSTS:216732

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adult behavior	ISO Inferred from Sequence Orthology more info
involved_in adult behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic vesicle docking	ISO Inferred from Sequence Orthology more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in social behavior	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon terminus	ISO Inferred from Sequence Orthology more info
is_active_in calyx of Held	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
part_of septin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	IDA Inferred from Direct Assay more info	PubMed
part_of septin complex	ISO Inferred from Sequence Orthology more info
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in terminal bouton	HDA more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: septin-5

Names: GP-Ib beta; Platelet glycoprotein Ib beta chain; cell division control-related protein 1; peanut-like 1; peanut-like protein 1

NP_446383.4

EC 3.1.5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053931.4 → NP_446383.4 septin-5

See identical proteins and their annotated locations for NP_446383.4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A6JSF3, A6JSF4, D3ZDH8

Related

ENSRNOP00000039995.3, ENSRNOT00000041168.7

Conserved Domains (2) summary

COG5019
Location:32 → 360

CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

pfam00735
Location:50 → 322

Septin; Septin