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    Pyurf PIGY upstream open reading frame [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502782, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pyurfprovided by RGD
    Official Full Name
    PIGY upstream open reading frameprovided by RGD
    Primary source
    RGD:1565524
    See related
    AllianceGenome:RGD:1565524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pigy; Prey; Pyurfl1
    Summary
    Predicted to be involved in protein stabilization. Predicted to be located in endoplasmic reticulum membrane and mitochondrion. Orthologous to human PYURF (PIGY upstream open reading frame). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 198.6), Muscle (RPKM 161.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pyurf in Genome Data Viewer
    Location:
    4q24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (88832008..88835643)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (87501859..87505494)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (88584242..88587877)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene VOPP1 WW domain binding protein Neighboring gene LanC like glutathione S-transferase 2 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 Neighboring gene ribosomal protein S7, pseudogene 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component. Murakami Y, et al. Mol Biol Cell, 2005 Nov. PMID 16162815, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein preY, mitochondrial
    Names
    PIGY upstream reading frame
    PIGY upstream reading frame-like 1
    phosphatidylinositol glycan anchor biosynthesis, class Y

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024370.2 → NP_001019541.1  protein preY, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001019541.1

      Status: VALIDATED

      Source sequence(s)
      BC086361, DV720704, JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q5U1Z8
      UniProtKB/TrEMBL
      A6K133
      Conserved Domains (1) summary
      COG2835
      Location:50 → 105
      YcaR; Uncharacterized conserved protein YbaR, Trm112 family [Function unknown]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      88832008..88835643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U1Z8.1 GenPept UniProtKB/Swiss-Prot:Q5U1Z8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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