Nsrp1 nuclear speckle splicing regulatory protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nsrp1provided by RGD
Official Full Name: nuclear speckle splicing regulatory protein 1provided by RGD
Primary source: RGD:1309863
See related: EnsemblRapid:ENSRNOG00000062400 AllianceGenome:RGD:1309863
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ccdc55; NSrp70; RGD1309863
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in developmental process and regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in nuclear speck. Predicted to be part of ribonucleoprotein complex. Orthologous to human NSRP1 (nuclear speckle splicing regulatory protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 39.7), Thymus (RPKM 38.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (62378937..62412601, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (61880807..61914471, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (63098115..63131779)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH136806 (e-PCR)
- UniSTS:218895

d10rat161 (e-PCR)
- UniSTS:120673

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in developmental process	ISO Inferred from Sequence Orthology more info
involved_in developmental process	ISS Inferred from Sequence or Structural Similarity more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nuclear speckle splicing regulatory protein 1

Names: coiled-coil domain containing 55; coiled-coil domain-containing protein 55; nuclear speckle-related protein 70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037189.1 → NP_001032266.1 nuclear speckle splicing regulatory protein 1

See identical proteins and their annotated locations for NP_001032266.1

Status: PROVISIONAL

Source sequence(s)

BC099120

UniProtKB/Swiss-Prot

Q4FZU3

UniProtKB/TrEMBL

A0A8I6A7W2, A6HGX1

Related

ENSRNOP00000087935.1, ENSRNOT00000107073.2

Conserved Domains (3) summary

TIGR01642
Location:365 → 483

U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

pfam09745
Location:57 → 176

DUF2040; Coiled-coil domain-containing protein 55 (DUF2040)

NF033845
Location:238 → 503

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB