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    Cnbp CCHC-type zinc finger, nucleic acid binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64530, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cnbpprovided by RGD
    Official Full Name
    CCHC-type zinc finger, nucleic acid binding proteinprovided by RGD
    Primary source
    RGD:621807
    See related
    EnsemblRapid:ENSRNOG00000010239 AllianceGenome:RGD:621807
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf9; Cnbp1
    Summary
    Enables single-stranded DNA binding activity and single-stranded RNA binding activity. Predicted to be involved in G-quadruplex DNA formation; positive regulation of cell population proliferation; and regulation of gene expression. Predicted to be located in cytosol; endoplasmic reticulum; and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in myotonic dystrophy type 2. Orthologous to human CNBP (CCHC-type zinc finger nucleic acid binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 3356.9), Heart (RPKM 2167.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cnbp in Genome Data Viewer
    Location:
    4q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (121860102..121868976, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (120302768..120311694, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (119747890..119756787, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RAB43, member RAS oncogene family Neighboring gene ISY1 splicing factor homolog Neighboring gene glutathione S-transferase alpha 4, pseudogene 4 Neighboring gene uncharacterized LOC134486609

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of rat cellular nucleic acid binding protein (CNBP) cDNA. Yasuda J, et al. DNA Res, 1995. PMID 7788528
    2. Mechanistic studies for the role of cellular nucleic-acid-binding protein (CNBP) in regulation of c-myc transcription. Chen S, et al. Biochim Biophys Acta, 2013 Oct. PMID 23774591
    3. The myotonic dystrophy type 2 (DM2) gene product zinc finger protein 9 (ZNF9) is associated with sarcomeres and normally localized in DM2 patients' muscles. Massa R, et al. Neuropathol Appl Neurobiol, 2010 Jun. PMID 20102514
    4. Molecular cloning, developmental expression, promoter analysis and functional characterization of the mouse CNBP gene. Shimizu K, et al. Gene, 2003 Mar 27. PMID 12706888
    5. Haploinsuffciency for Znf9 in Znf9+/- mice is associated with multiorgan abnormalities resembling myotonic dystrophy. Chen W, et al. J Mol Biol, 2007 Apr 20. PMID 17335846

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings showed that ZNF9 is ubiquitously expressed in mammalian tissues, and that its signal is not substantially modified in myotonic dystrophy type 2 muscles
      Title: The myotonic dystrophy type 2 (DM2) gene product zinc finger protein 9 (ZNF9) is associated with sarcomeres and normally localized in DM2 patients' muscles.
    2. Znf9 haploinsufficiency contributes to the myotonic dystrophy phenotype in Znf9+/- mice.
      Title: Haploinsuffciency for Znf9 in Znf9+/- mice is associated with multiorgan abnormalities resembling myotonic dystrophy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-quadruplex DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-quadruplex DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G-quadruplex DNA formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G-quadruplex DNA formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    CCHC-type zinc finger nucleic acid binding protein
    Names
    cellular nucleic acid binding protein 1
    cellular nucleic acid-binding protein
    zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022598.1 → NP_072120.1  CCHC-type zinc finger nucleic acid binding protein

      See identical proteins and their annotated locations for NP_072120.1

      Status: PROVISIONAL

      Source sequence(s)
      D45254
      UniProtKB/Swiss-Prot
      P62634, Q5QJQ8
      UniProtKB/TrEMBL
      A6IB27
      Conserved Domains (1) summary
      PTZ00368
      Location:54 → 171
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      121860102..121868976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236854.5 → XP_006236916.1  CCHC-type zinc finger nucleic acid binding protein isoform X3

      See identical proteins and their annotated locations for XP_006236916.1

      UniProtKB/TrEMBL
      A6IB26
      Related
      ENSRNOP00000013884.7, ENSRNOT00000013884.8
      Conserved Domains (1) summary
      PTZ00368
      Location:47 → 164
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

    2. XM_017592879.3 → XP_017448368.1  CCHC-type zinc finger nucleic acid binding protein isoform X2

      Conserved Domains (1) summary
      PTZ00368
      Location:47 → 165
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

    3. XM_017592878.3 → XP_017448367.1  CCHC-type zinc finger nucleic acid binding protein isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q6G7
      Conserved Domains (1) summary
      PTZ00368
      Location:54 → 172
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62634.1 GenPept UniProtKB/Swiss-Prot:P62634

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